F. J. Hernández-Fernández
Exploring ionic liquids based on pyrrolidinium and imidazolium cations with low toxicity towards Escherichia coli for designing sustainable bioprocesses
Hernández-Fernández, F. J.; de los Ríos, A. P.; Licence, P.; Stephens, G.
Authors
A. P. de los Ríos
Professor PETER LICENCE PETER.LICENCE@NOTTINGHAM.AC.UK
PROFESSOR OF CHEMISTRY
G. Stephens
Abstract
Ionic liquids (ILs) are widely applied in many bioprocesses involving microorganisms due to their unique properties. In this work, the toxicity of imidazolium and pyrrolidinium ionic liquids towards E. coli., a bacterium for which there are limited toxicity data in the literature, was determined. For its simplicity, the nephelometry method was used to estimate ionic liquid toxicity values. The influence of the cation and the alkyl chain length of the cation and anion was analysed. Pyrrolidinium cations were seen to be less toxic than imidazolium cations, while an increase in the alkyl chain length of both pyrrolidinium and imidazolium cations increased the toxicity. Among the anions studied, dimethylphosphate ([Me2PO4]) was the less toxic, while the EC50 for the ionic liquid 1-butyl-3-methylpyrrolidinium dimethylphosphate ([C1C4Pyr][Me2PO4]) was close to 200 mM. Furthermore, a dicationic ionic liquid based on imidazolium and pyrrolidinium cations was synthetized and its toxicity toward E. coli was analysed, maintaining a growth rate of 100% in the range 0-0.76 mM. The methodology used in this work allows to easily find the less toxic ionic liquids that are biocompatible with E. coli to be used in new bioprocesses.
Citation
Hernández-Fernández, F. J., de los Ríos, A. P., Licence, P., & Stephens, G. (2022). Exploring ionic liquids based on pyrrolidinium and imidazolium cations with low toxicity towards Escherichia coli for designing sustainable bioprocesses. Journal of Biotechnology, 360, 192-197. https://doi.org/10.1016/j.jbiotec.2022.11.001
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 2, 2022 |
Online Publication Date | Nov 5, 2022 |
Publication Date | Dec 10, 2022 |
Deposit Date | Nov 7, 2022 |
Publicly Available Date | Nov 10, 2022 |
Journal | Journal of Biotechnology |
Print ISSN | 0168-1656 |
Electronic ISSN | 1873-4863 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 360 |
Pages | 192-197 |
DOI | https://doi.org/10.1016/j.jbiotec.2022.11.001 |
Keywords | Applied Microbiology and Biotechnology; General Medicine; Biotechnology; Bioengineering |
Public URL | https://nottingham-repository.worktribe.com/output/13451088 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0168165622002632?via%3Dihub |
Files
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(1.4 Mb)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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