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Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols

Panchal, Heena; Clarke, Christopher; Bell, Charles; Karad, Somnath Narayan; Lewis, William; Lam, Hon Wai


Heena Panchal

Christopher Clarke

Charles Bell

Somnath Narayan Karad

William Lewis

Professor of Sustainable Chemistry


Nickel-catalyzed, highly diastereoselective annulations between activated allenes and 2-acetylarylboronic acid or 2-formylarylboronic acids are reported. No ligand for nickel is required, and the reactions proceed efficiently at room temperature to give a broad range of substituted 3-methyleneindan-1-ols. Preliminary results of an enantioselective variant are also described.


Panchal, H., Clarke, C., Bell, C., Karad, S. N., Lewis, W., & Lam, H. W. (2018). Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols. Chemical Communications, 54(87), 12389-12392.

Journal Article Type Article
Acceptance Date Oct 10, 2018
Publication Date Oct 11, 2018
Deposit Date Oct 16, 2018
Publicly Available Date Oct 12, 2019
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 54
Issue 87
Pages 12389-12392
Keywords Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
Public URL
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Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Authors can choose between single-blind and double-blind peer review; : Received 6 August 2018; Accepted 10 October 2018; Accepted Manuscript published 11 October 2018


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