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Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols

Panchal, Heena; Clarke, Christopher; Bell, Charles; Karad, Somnath Narayan; Lewis, William; Lam, Hon Wai


Heena Panchal

Christopher Clarke

Charles Bell

Somnath Narayan Karad

William Lewis

Professor of Sustainable Chemistry


Nickel-catalyzed, highly diastereoselective annulations between activated allenes and 2-acetylarylboronic acid or 2-formylarylboronic acids are reported. No ligand for nickel is required, and the reactions proceed efficiently at room temperature to give a broad range of substituted 3-methyleneindan-1-ols. Preliminary results of an enantioselective variant are also described.

Journal Article Type Article
Publication Date Oct 11, 2018
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 54
Issue 87
Pages 12389-12392
APA6 Citation Panchal, H., Clarke, C., Bell, C., Karad, S. N., Lewis, W., & Lam, H. W. (2018). Nickel-catalyzed, ligand-free, diastereoselective synthesis of 3-methyleneindan-1-ols. Chemical Communications, 54(87), 12389-12392. doi:10.1039/c8cc06388e
Keywords Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
Publisher URL!divAbstract
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Authors can choose between single-blind and double-blind peer review; : Received 6 August 2018; Accepted 10 October 2018; Accepted Manuscript published 11 October 2018


HWL Nickel-Catalyzed Synthesis Of 3-Methyleneindan-1-ols (Revised) (1.4 Mb)

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