Concise review: Emerging Drugs Targeting Epithelial Cancer Stem-like Cells

Ahmed, Mehreen; Chaudhari, Kritika; Babaei?Jadidi, Roya; Dekker, Lodewijk V.; Shams Nateri, Abdolrahman

Abstract

Increasing evidence suggests that cancer cell populations contain a small proportion of cells that display stem‐like cell properties and which may be responsible for overall tumor maintenance. These cancer stem‐like cells (CSCs) appear to have unique tumor‐initiating ability and innate survival mechanisms that allow them to resist cancer therapies, consequently promoting relapses. Selective targeting of CSCs may provide therapeutic benefit and several recent reports have indicated this may be possible. In this article, we review drugs targeting CSCs, in selected epithelial cell‐derived cancers.

Citation

Ahmed, M., Chaudhari, K., Babaei‐Jadidi, R., Dekker, L. V., & Shams Nateri, A. (2017). Concise review: Emerging Drugs Targeting Epithelial Cancer Stem-like Cells. STEM CELLS, 35(4), 839-850. https://doi.org/10.1002/stem.2579

• Journal Article Type: Article
• Acceptance Date: Jan 7, 2017
• Online Publication Date: Jan 31, 2017
• Publication Date: Apr 1, 2017
• Deposit Date: Aug 13, 2018
• Publicly Available Date: Dec 13, 2018
• Print ISSN: 1066-5099
• Electronic ISSN: 1549-4918
• Publisher: AlphaMed Press
• Peer Reviewed: Peer Reviewed
• Volume: 35
• Issue: 4
• Pages: 839-850
• DOI: https://doi.org/10.1002/stem.2579
• Public URL: https://nottingham-repository.worktribe.com/output/1120256
• Publisher URL: https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.2579
• PMID: 28142204