Skip to main content

Research Repository

Advanced Search

Reactive clusters on a membrane

Thul, Ruediger; Falcke, Martin


Martin Falcke


We investigate the reaction dynamics of diffusive molecules with immobile binding partners. The fixed reactants build clusters that comprise just a few tens of molecules, which leads to small cluster sizes. These molecules participate in the reaction only if they are activated. The dynamics of activation is mapped to a time-dependent size of an active region within the cluster. We focus on the deterministic description of the dynamics of a single cluster. The
spatial setup accounts for one of the most important determinants of the dynamics of a cluster, i.e. diffusional transport of reaction partners toward or away from the active region of the cluster. We provide numerical and analytical evidence that diffusion influences decisively the dynamic regimes of the reactions. The application of our methods to intracellular Ca²⁺ dynamics shows that large local concentrations saturate the Ca²⁺ feedback to the channel state control. That eliminates oscillations depending on this feedback.


Thul, R., & Falcke, M. (2005). Reactive clusters on a membrane. Physical Biology, 2,

Journal Article Type Article
Publication Date Jan 1, 2005
Deposit Date Nov 19, 2008
Publicly Available Date Nov 19, 2008
Journal Physical Biology
Electronic ISSN 1478-3967
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 2
Public URL
Publisher URL


You might also like

Downloadable Citations