A beginner's guide to systems simulation in immunology

Figueredo, Grazziela P.; Siebers, Peer-Olaf; Aickelin, Uwe; Foan, Stephanie

Abstract

Some common systems modelling and simulation approaches for immune problems are Monte Carlo simulations, system dynamics, discrete-event simulation and agent-based simulation. These methods, however, are still not widely adopted in immunology research. In addition, to our knowledge, there is few research on the processes for the development of simulation models for the immune system. Hence, for this work, we have two contributions to knowledge. The first one is to show the importance of
systems simulation to help immunological research and to draw the attention of simulation developers to this research field. The second contribution is the introduction of a quick guide containing the main steps for modelling and simulation in immunology, together with challenges that occur during the model development. Further, this paper introduces an example of a simulation problem, where we test our guidelines.

Citation

Figueredo, G. P., Siebers, P.-O., Aickelin, U., & Foan, S. (2012). A beginner's guide to systems simulation in immunology. In C. A. Coello Coello, J. Greensmith, N. Krasnogor, P. Liò, G. Nicosia, & M. Pavone (Eds.), Artificial immune systems: 11th International Conference, ICARIS 2012, Taormina, Italy, August 28-31, 2012: proceedings. Springer

• Publication Date: Jan 1, 2012
• Deposit Date: Jun 19, 2013
• Publicly Available Date: Jun 19, 2013
• Peer Reviewed: Peer Reviewed
• Issue: 7597
• Series Title: Lecture notes in computer science
• Book Title: Artificial immune systems: 11th International Conference, ICARIS 2012, Taormina, Italy, August 28-31, 2012: proceedings
• ISBN: 9783642337574
• Public URL: https://nottingham-repository.worktribe.com/output/1008699
• Publisher URL: http://www.springer.com/computer/theoretical+computer+science/book/978-3-642-33756-7
• Additional Information: Paper presented at: 11th International Conference on Artificial Immune Systems, ICARIS 2012, Taormina, Italy, 28-31 August 2012.