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Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans

Stephens, Francis B.; Wall, Benjamin T.; Marimuthu, Kanagaraj; Shannon, Chris E.; Constantin-Teodosiu, Dumitru; MacDonald, Ian A.; Greenhaff, Paul L.

Authors

Francis B. Stephens

Benjamin T. Wall

Kanagaraj Marimuthu

Chris E. Shannon

Dumitru Constantin-Teodosiu

Ian A. MacDonald

Paul L. Greenhaff



Abstract

Twelve weeks of daily L-carnitine and carbohydrate feeding in humans increases skeletal muscle total carnitine content, and prevents body mass accrual associated with carbohydrate feeding alone. Here we determined the influence of L-carnitine and carbohydrate feeding on
energy metabolism, body fat mass andmuscle expression of fuel metabolism genes. Twelve males exercised at 50% maximal oxygen consumption for 30 min once before and once after 12 weeks of twice daily feeding of 80 g carbohydrate (Control, n=6) or 1.36 g L-carnitine+80 g carbohydrate
(Carnitine, n=6). Maximal carnitine palmitolytransferase 1 (CPT1) activity remained similar in both groups over 12 weeks. However, whereas muscle total carnitine, long-chain acyl-CoA and whole-body energy expenditure did not change over 12 weeks in Control, they increased in Carnitine by 20%, 200% and 6%, respectively (P

Journal Article Type Article
Publication Date Sep 1, 2013
Journal Journal of Physiology
Print ISSN 0022-3751
Electronic ISSN 0022-3751
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 591
Issue 18
APA6 Citation Stephens, F. B., Wall, B. T., Marimuthu, K., Shannon, C. E., Constantin-Teodosiu, D., MacDonald, I. A., & Greenhaff, P. L. (2013). Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans. Journal of Physiology, 591(18), doi:10.1113/jphysiol.2013.255364
DOI https://doi.org/10.1113/jphysiol.2013.255364
Publisher URL http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2013.255364/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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