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Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans

Stephens, Francis B.; Wall, Benjamin T.; Marimuthu, Kanagaraj; Shannon, Chris E.; Constantin-Teodosiu, Dumitru; MacDonald, Ian A.; Greenhaff, Paul L.

Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans Thumbnail


Authors

Benjamin T. Wall

Kanagaraj Marimuthu

Chris E. Shannon

Dumitru Constantin-Teodosiu

Ian A. MacDonald

Paul L. Greenhaff



Abstract

Twelve weeks of daily L-carnitine and carbohydrate feeding in humans increases skeletal muscle total carnitine content, and prevents body mass accrual associated with carbohydrate feeding alone. Here we determined the influence of L-carnitine and carbohydrate feeding on
energy metabolism, body fat mass andmuscle expression of fuel metabolism genes. Twelve males exercised at 50% maximal oxygen consumption for 30 min once before and once after 12 weeks of twice daily feeding of 80 g carbohydrate (Control, n=6) or 1.36 g L-carnitine+80 g carbohydrate
(Carnitine, n=6). Maximal carnitine palmitolytransferase 1 (CPT1) activity remained similar in both groups over 12 weeks. However, whereas muscle total carnitine, long-chain acyl-CoA and whole-body energy expenditure did not change over 12 weeks in Control, they increased in Carnitine by 20%, 200% and 6%, respectively (P

Citation

Stephens, F. B., Wall, B. T., Marimuthu, K., Shannon, C. E., Constantin-Teodosiu, D., MacDonald, I. A., & Greenhaff, P. L. (2013). Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans. Journal of Physiology, 591(18), https://doi.org/10.1113/jphysiol.2013.255364

Journal Article Type Article
Publication Date Sep 1, 2013
Deposit Date Apr 17, 2014
Publicly Available Date Mar 28, 2024
Journal Journal of Physiology
Print ISSN 0022-3751
Electronic ISSN 0022-3751
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 591
Issue 18
DOI https://doi.org/10.1113/jphysiol.2013.255364
Public URL https://nottingham-repository.worktribe.com/output/1001363
Publisher URL http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2013.255364/abstract

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