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Comparison of algorithms that detect drug side effects using electronic healthcare databases

Reps, Jenna M.; Garibaldi, Jonathan M.; Aickelin, Uwe; Soria, Daniele; Gibson, Jack E.; Hubbard, Richard B.

Authors

Jenna M. Reps

Jonathan M. Garibaldi

Uwe Aickelin

Daniele Soria

Jack E. Gibson

Richard B. Hubbard



Abstract

The electronic healthcare databases are starting to become more readily available and are thought to have excellent potential for generating adverse drug reaction signals. The Health Improvement Network (THIN) database is an electronic healthcare database containing medical information on over 11 million patients that has excellent potential for detecting ADRs. In this paper we apply four existing electronic healthcare database signal detecting algorithms (MUTARA, HUNT, Temporal Pattern Discovery and modified ROR) on the THIN database for a selection of drugs from six chosen drug families. This is the first comparison of ADR signalling algorithms that includes MUTARA and HUNT and enabled us to set a benchmark for the adverse drug reaction signalling ability of the THIN database. The drugs were selectively chosen to enable a comparison with previous work and for variety. It was found that no algorithm was generally superior and the algorithms’ natural thresholds act at variable stringencies. Furthermore, none of the algorithms perform well at detecting rare ADRs.

Citation

Reps, J. M., Garibaldi, J. M., Aickelin, U., Soria, D., Gibson, J. E., & Hubbard, R. B. (2013). Comparison of algorithms that detect drug side effects using electronic healthcare databases. Soft Computing, 17(12), doi:10.1007/s00500-013-1097-4

Journal Article Type Article
Publication Date Dec 1, 2013
Deposit Date Sep 27, 2014
Publicly Available Date Sep 27, 2014
Journal Soft Computing
Print ISSN 1432-7643
Electronic ISSN 1432-7643
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 17
Issue 12
DOI https://doi.org/10.1007/s00500-013-1097-4
Keywords Biomedical Informatics, Data Mining
Public URL http://eprints.nottingham.ac.uk/id/eprint/3343
Publisher URL http://link.springer.com/article/10.1007/s00500-013-1097-4
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s00500-013-1097-4

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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