Outputs (6)

Assessing muscle protein synthesis rates in vivo in humans: the deuterated water (2H2O) method (2024)
Journal Article
Holwerda, A. M., Atherton, P. J., Smith, K., Wilkinson, D. J., Phillips, S. M., & van Loon, L. J. (2024). Assessing muscle protein synthesis rates in vivo in humans: the deuterated water (2H2O) method. Journal of Nutrition, 154(11), 3177-3189. https://doi.org/10.1016/j.tjnut.2024.09.012

Skeletal muscle tissue is in a constant state of turnover, with muscle tissue protein synthesis and breakdown rates ranging between 1-2 % across the day in vivo in humans. Muscle tissue remodeling is largely controlled by the up- and down-regulation... Read More about Assessing muscle protein synthesis rates in vivo in humans: the deuterated water (2H2O) method.

Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus (2024)
Journal Article
Oluwaseun, A., Bethan, P., Katie, Q., Daniel, W., Kenneth, S., Philip, A., & Iskandar, I. (2024). Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus. Clinical Nutrition, 43(8), 1907-1913. https://doi.org/10.1016/j.clnu.2024.06.034

Background & aims

Very-low calorie diets (VLCD) and the glucagon-like peptide-1 receptor agonist (GLP1RA) Semaglutide induce significant weight loss and improve glycaemic control in individuals with type 2 diabetes (T2D). This pilot study was cond... Read More about Metabolic effects of very-low calorie diet, Semaglutide or combination of the two, in individuals with type 2 diabetes mellitus.

Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism (2024)
Journal Article
Shur, N. F., Simpson, E. J., Crossland, H., Constantin, D., Cordon, S. M., Constantin-Teodosiu, D., Stephens, F. B., Brook, M. S., Atherton, P. J., Smith, K., Wilkinson, D. J., Mougin, O. E., Bradley, C., Macdonald, I. A., & Greenhaff, P. L. (2024). Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism. Journal of Cachexia, Sarcopenia and Muscle, 15(2), 603-614. https://doi.org/10.1002/jcsm.13431

Background
Bed-rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in the same ind... Read More about Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism.

Molecular mechanisms underpinning favourable physiological adaptations to exercise prehabilitation for urological cancer surgery (2023)
Journal Article
Blackwell, J. E., Gharahdaghi, N., Deane, C. S., Brook, M. S., Williams, J. P., Lund, J. N., Atherton, P. J., Smith, K., Wilkinson, D. J., & Phillips, B. E. (2024). Molecular mechanisms underpinning favourable physiological adaptations to exercise prehabilitation for urological cancer surgery. Prostate Cancer and Prostatic Diseases, 27, 219-231. https://doi.org/10.1038/s41391-023-00774-z

BACKGROUND: Surgery for urological cancers is associated with high complication rates and survivors commonly experience fatigue, reduced physical ability and quality of life. High-intensity interval training (HIIT) as surgical prehabilitation has bee... Read More about Molecular mechanisms underpinning favourable physiological adaptations to exercise prehabilitation for urological cancer surgery.

Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women (2023)
Journal Article
Mallinson, J. E., Wardle, S. L., O'Leary, T. J., Greeves, J. P., Cegielski, J., Bass, J., Brook, M. S., Wilkinson, D. J., Smith, K., Atherton, P. J., & Greenhaff, P. L. (2023). Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women. Scandinavian Journal of Medicine and Science in Sports, 33(12), 2470-2481. https://doi.org/10.1111/sms.14506

Studies examining the effect of protein (PRO) feeding on post resistance exercise (RE) muscle protein synthesis (MPS) have primarily been performed in men, and little evidence is available regarding the quantity of PRO required to maximally stimulate... Read More about Protein dose requirements to maximise skeletal muscle protein synthesis after repeated bouts of resistance exercise in young trained women.

#3716 EFFECT OF IMMUNO-NUTRITION ON SYSTEMIC INFLAMMATION AND MUSCLE MASS IN A HAEMODIALYSIS POPULATION: A FEASIBILITY STUDY (2023)
Presentation / Conference Contribution
Hörner, D. V., Phillips, B., Atherton, P., Smith, K., Wilkinson, D., Selby, N., & Taal, M. (2023, June). #3716 EFFECT OF IMMUNO-NUTRITION ON SYSTEMIC INFLAMMATION AND MUSCLE MASS IN A HAEMODIALYSIS POPULATION: A FEASIBILITY STUDY. Presented at 60th European Renal Association Congress, Milan, Italy and online

Background and Aims
Decreased skeletal muscle mass (SMM) and systemic inflammation are frequent complications associated with poor outcomes in people receiving haemodialysis. Although these problems are widely acknowledged, it has become clear that... Read More about #3716 EFFECT OF IMMUNO-NUTRITION ON SYSTEMIC INFLAMMATION AND MUSCLE MASS IN A HAEMODIALYSIS POPULATION: A FEASIBILITY STUDY.