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Outputs (165)

Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial (2024)
Journal Article
Kouraki, A., Nogal, A., Nocun, W., Louca, P., Vijay, A., Wong, K., …Valdes, A. M. (2024). Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites, 14(6), Article 311. https://doi.org/10.3390/metabo14060311

Metabolomics can uncover physiological responses to prebiotic fibre and omega-3 fatty acid supplements with known health benefits and identify response-specific metabolites. We profiled 534 stool and 799 serum metabolites in 64 healthy adults followi... Read More about Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial.

A modern way to teach and practice manual therapy (2024)
Journal Article
Kerry, R., Young, K. J., Evans, D. W., Lee, E., Georgopoulos, V., Meakins, A., …Hutting, N. (2024). A modern way to teach and practice manual therapy. Chiropractic & Manual Therapies, 32(1), Article 17. https://doi.org/10.1186/s12998-024-00537-0

Background: Musculoskeletal conditions are the leading contributor to global disability and health burden. Manual therapy (MT) interventions are commonly recommended in clinical guidelines and used in the management of musculoskeletal conditions. Tra... Read More about A modern way to teach and practice manual therapy.

Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol (2024)
Journal Article
Chouliara, N., Cameron, T., Ballard-Ridley, S., Fisher, R. J., Kettlewell, J., Kidd, L., …Gordon, A. L. (2024). Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol. Healthcare, 12(10), Article 1027. https://doi.org/10.3390/healthcare12101027

Telerehabilitation (TR) shows promise as a method of remote service delivery, yet there is little guidance to inform implementation in the context of the National Health Service (NHS) in England. This paper presents the protocol for a realist synthes... Read More about Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol.

The influence of immobility on muscle loss in older people with frailty and fragility fractures (2024)
Journal Article
Lunt, E. K., Gordon, A. L., Greenhaff, P. L., & Gladman, J. F. R. (2024). The influence of immobility on muscle loss in older people with frailty and fragility fractures. GeroScience, https://doi.org/10.1007/s11357-024-01177-1

This longitudinal study aimed to assess muscle morphological and functional changes in older patients admitted with fragility fractures managed by immobilisation of the affected limb for at least 6 weeks. Patients aged ≥ 70 hospitalised with non-weig... Read More about The influence of immobility on muscle loss in older people with frailty and fragility fractures.

Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial (2024)
Journal Article
Bermingham, K. M., Linenberg, I., Polidori, L., Asnicar, F., Arrè, A., Wolf, J., …Berry, S. E. (2024). Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nature Medicine, https://doi.org/10.1038/s41591-024-02951-6

Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health... Read More about Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.

A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications (2024)
Journal Article
Abuawwad, M., Tibude, A., Bansi, D., Idris, I., & Madhok, B. (2024). A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications. Diabetes, Obesity and Metabolism, 26(7), 2546-2553. https://doi.org/10.1111/dom.15613

Metabolic and bariatric surgeries have been shown to be the most effective strategy to induce and maintain significant weight loss for people living with severe obesity. However, ongoing concerns regarding operative risks, irreversibility and excess... Read More about A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications.

Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials (2024)
Journal Article
Balsby, I. M., Nielsen, S. M., Christensen, R., Henriksen, M., Dahl, L. U., Berg, J. I., …Døssing, A. (2024). Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials. Osteoarthritis and Cartilage, https://doi.org/10.1016/j.joca.2024.02.947

Objective: To examine the pain relief effects of comparators (placebos and untreated control groups) in hand osteoarthritis trials and the impact of contextual factors. Methods: We systematically searched PubMed, EMBASE and CENTRAL from inception to... Read More about Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials.

Factors influencing the commissioning and implementation of health and social care interventions for people with dementia: commissioner and stakeholder perspectives (2024)
Journal Article
Tucker, R., Vickers, R., Adams, E. J., Burgon, C., Lock, J., Goldberg, S. E., …Harwood, R. H. (2024). Factors influencing the commissioning and implementation of health and social care interventions for people with dementia: commissioner and stakeholder perspectives. Archives of Public Health, 82(1), Article 54. https://doi.org/10.1186/s13690-024-01283-8

Background Despite several interventions demonstrating benefit to people living with dementia and their caregivers, few have been translated and implemented in routine clinical practice. There is limited evidence of the barriers and facilitators for... Read More about Factors influencing the commissioning and implementation of health and social care interventions for people with dementia: commissioner and stakeholder perspectives.

Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study (2024)
Journal Article
Thomas, S., Littleboy, K., Foubert, J., Nafilyan, V., Bannister, N., Routen, A., …Gordon, A. L. (2024). Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study. Age and Ageing, 53(4), Article afae071. https://doi.org/10.1093/ageing/afae071

Background: Older people with frailty are at risk of harm from immobility or isolation, yet data about how COVID-19 lockdowns affected them are limited. Falls and fractures are easily measurable adverse outcomes correlated with frailty. We investigat... Read More about Impact of the COVID-19 pandemic on hospital episodes for falls and fractures associated with new-onset disability and frailty in England: a national cohort study.

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2024)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., …Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559-564. https://doi.org/10.1093/bjd/ljad430

Background: There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives: To evaluate the... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.