Outputs (251)

Digital Twins of Acute Hypoxemic Respiratory Failure Patients Suggest a Mechanistic Basis for Success and Failure of Noninvasive Ventilation (2024)
Journal Article
Weaver, L., Shamohammadi, H., Saffaran, S., Tonelli, R., Laviola, M., Laffey, J. G., Camporota, L., Scott, T. E., Hardman, J. G., Clini, E., & Bates, D. G. (2024). Digital Twins of Acute Hypoxemic Respiratory Failure Patients Suggest a Mechanistic Basis for Success and Failure of Noninvasive Ventilation. Critical Care Medicine, 52(9), e473-e484. https://doi.org/10.1097/CCM.0000000000006337

Objectives: To clarify the mechanistic basis for the success or failure of noninvasive ventilation (NIV) in acute hypoxemic respiratory failure (AHRF). Design: We created digital twins based on mechanistic computational models of individual patients... Read More about Digital Twins of Acute Hypoxemic Respiratory Failure Patients Suggest a Mechanistic Basis for Success and Failure of Noninvasive Ventilation.

Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial (2024)
Journal Article
Kouraki, A., Nogal, A., Nocun, W., Louca, P., Vijay, A., Wong, K., Michelotti, G. A., Menni, C., & Valdes, A. M. (2024). Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial. Metabolites, 14(6), Article 311. https://doi.org/10.3390/metabo14060311

Metabolomics can uncover physiological responses to prebiotic fibre and omega-3 fatty acid supplements with known health benefits and identify response-specific metabolites. We profiled 534 stool and 799 serum metabolites in 64 healthy adults followi... Read More about Machine Learning Metabolomics Profiling of Dietary Interventions from a Six-Week Randomised Trial.

Pre- and post-operative voice therapy for benign vocal fold lesions: protocol for a non-randomised, multicentre feasibility trial with embedded process evaluation (2024)
Journal Article
White, A., Carding, P., Booth, V., McGlashan, J., Van Stan, J., Logan, P., & Awad, R. (2024). Pre- and post-operative voice therapy for benign vocal fold lesions: protocol for a non-randomised, multicentre feasibility trial with embedded process evaluation. Pilot and Feasibility Studies, 10, Article 84. https://doi.org/10.1186/s40814-024-01508-1

Background: Management of benign vocal fold lesions (BVFLs) is variable with individuals receiving surgery, voice therapy, or a combination of these approaches. Some evidence suggests that the best outcomes may be achieved when patients are offered p... Read More about Pre- and post-operative voice therapy for benign vocal fold lesions: protocol for a non-randomised, multicentre feasibility trial with embedded process evaluation.

A modern way to teach and practice manual therapy (2024)
Journal Article
Kerry, R., Young, K. J., Evans, D. W., Lee, E., Georgopoulos, V., Meakins, A., McCarthy, C., Cook, C., Ridehalgh, C., Vogel, S., Banton, A., Bergström, C., Mazzieri, A. M., Mourad, F., & Hutting, N. (2024). A modern way to teach and practice manual therapy. Chiropractic & Manual Therapies, 32(1), Article 17. https://doi.org/10.1186/s12998-024-00537-0

Background: Musculoskeletal conditions are the leading contributor to global disability and health burden. Manual therapy (MT) interventions are commonly recommended in clinical guidelines and used in the management of musculoskeletal conditions. Tra... Read More about A modern way to teach and practice manual therapy.

Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol (2024)
Journal Article
Chouliara, N., Cameron, T., Ballard-Ridley, S., Fisher, R. J., Kettlewell, J., Kidd, L., Luxton, L., Pomeroy, V., Stockley, R. C., Thomas, S., & Gordon, A. L. (2024). Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol. Healthcare, 12(10), Article 1027. https://doi.org/10.3390/healthcare12101027

Telerehabilitation (TR) shows promise as a method of remote service delivery, yet there is little guidance to inform implementation in the context of the National Health Service (NHS) in England. This paper presents the protocol for a realist synthes... Read More about Investigating the Implementation of Community-Based Stroke Telerehabilitation in England; A Realist Synthesis Study Protocol.

The influence of immobility on muscle loss in older people with frailty and fragility fractures (2024)
Journal Article
Lunt, E. K., Gordon, A. L., Greenhaff, P. L., & Gladman, J. F. R. (2024). The influence of immobility on muscle loss in older people with frailty and fragility fractures. GeroScience, 46, 5473-5484. https://doi.org/10.1007/s11357-024-01177-1

This longitudinal study aimed to assess muscle morphological and functional changes in older patients admitted with fragility fractures managed by immobilisation of the affected limb for at least 6 weeks. Patients aged ≥ 70 hospitalised with non-weig... Read More about The influence of immobility on muscle loss in older people with frailty and fragility fractures.

Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial (2024)
Journal Article
Bermingham, K. M., Linenberg, I., Polidori, L., Asnicar, F., Arrè, A., Wolf, J., Badri, F., Bernard, H., Capdevila, J., Bulsiewicz, W. J., Gardner, C. D., Ordovas, J. M., Davies, R., Hadjigeorgiou, G., Hall, W. L., Delahanty, L. M., Valdes, A. M., Segata, N., Spector, T. D., & Berry, S. E. (2024). Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial. Nature Medicine, 30, 1888-1897. https://doi.org/10.1038/s41591-024-02951-6

Large variability exists in people’s responses to foods. However, the efficacy of personalized dietary advice for health remains understudied. We compared a personalized dietary program (PDP) versus general advice (control) on cardiometabolic health... Read More about Effects of a personalized nutrition program on cardiometabolic health: a randomized controlled trial.

A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications (2024)
Journal Article
Abuawwad, M., Tibude, A., Bansi, D., Idris, I., & Madhok, B. (2024). A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications. Diabetes, Obesity and Metabolism, 26(7), 2546-2553. https://doi.org/10.1111/dom.15613

Metabolic and bariatric surgeries have been shown to be the most effective strategy to induce and maintain significant weight loss for people living with severe obesity. However, ongoing concerns regarding operative risks, irreversibility and excess... Read More about A commentary review on endoscopic sleeve gastroplasty: Indications, outcomes and future implications.

Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials (2024)
Journal Article
Balsby, I. M., Nielsen, S. M., Christensen, R., Henriksen, M., Dahl, L. U.-M., Berg, J. I., Tarp, S., Kroon, F., Kloppenburg, M., Zhang, W., Hunter, D. J., Bliddal, H., & Døssing, A. (2024). Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials. Osteoarthritis and Cartilage, 32(7), 848-857. https://doi.org/10.1016/j.joca.2024.02.947

Objective: To examine the pain relief effects of comparators (placebos and untreated control groups) in hand osteoarthritis trials and the impact of contextual factors. Methods: We systematically searched PubMed, EMBASE and CENTRAL from inception to... Read More about Comparative effectiveness of different placebos and comparator groups for hand osteoarthritis exploring the impact of contextual factors: A systematic review and meta-analysis of randomised trials.

The Impact of Delirium on Recovery in Geriatric Rehabilitation after Acute Infection (2024)
Journal Article
Minnema, J., Polinder-Bos, H., Cesari, M., Dockery, F., Everink, I., Francis, B., Gordon, A., Grund, S., Perez Bazan, L., Eruslanova, K., Topinková, E., Vassallo, M., Faes, M., van Tol, L., Caljouw, M., Achterberg, W., & Haaksma, M. (2024). The Impact of Delirium on Recovery in Geriatric Rehabilitation after Acute Infection. Journal of the American Medical Directors Association, 25(8), Article 105002. https://doi.org/10.1016/j.jamda.2024.03.113

Objectives
Delirium is common during acute infection in older patients and is associated with functional decline. Geriatric rehabilitation (GR) can help older patients to return to their premorbid functional level. It is unknown whether delirium aff... Read More about The Impact of Delirium on Recovery in Geriatric Rehabilitation after Acute Infection.