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Outputs (32)

Assessing the prevalence and potential drivers of food insecurity and the relationship with mental wellbeing in UK university students: A cross-sectional study (2024)
Journal Article
Aldubaybi, A. A., Coneyworth, L. J., & Jethwa, P. H. (2024). Assessing the prevalence and potential drivers of food insecurity and the relationship with mental wellbeing in UK university students: A cross-sectional study. Nutrition Bulletin, 49(1), 96-107. https://doi.org/10.1111/nbu.12662

Food insecurity (FI) among university students in the United States has been associated with poor mental wellbeing, but very little is known about the relationship between FI and mental wellbeing in the UK university population. Here we examined the... Read More about Assessing the prevalence and potential drivers of food insecurity and the relationship with mental wellbeing in UK university students: A cross-sectional study.

Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter (2024)
Journal Article
Alliband, K. H., Parr, T., Jethwa, P. H., & Brameld, J. M. (2024). Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter. Frontiers in Physiology, 14, Article 1322677. https://doi.org/10.3389/fphys.2023.1322677

Background: Skeletal muscle development during embryogenesis depends on proliferation of myoblasts followed by differentiation into myotubes/multinucleated myofibers. Vitamin D (VD) has been shown to affect these processes, but there is conflicting e... Read More about Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter.

A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation (2022)
Journal Article
Huggett, Z. J., Smith, A., De Vivo, N., Gomez, D., Jethwa, P., Brameld, J. M., Bennett, A., & Salter, A. M. (2022). A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation. Nutrients, 15(1), Article 40. https://doi.org/10.3390/nu15010040

Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation within hepatocytes, but the relative contributions of different macronutrients is still unclear. We investigated the impact of fatty acids, glucose and fructose on lipid accumul... Read More about A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation.

Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review (2021)
Journal Article
Alharazi, W., McGowen, A., Rose, P., & Jethwa, P. H. (2022). Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review. British Journal of Nutrition, 128(4), 613-624. https://doi.org/10.1017/S0007114521003706

Yam (Dioscorea spp.) and its associated extracts have been shown to possess a variety of biological activities and identified as beneficial in the control of glycaemia in patients with Type II Diabetes Mellitus (T2DM). The objective was to conduct a... Read More about Could consumption of yam (Dioscorea) or its extract be beneficial in controlling glycaemia: a systematic review.

Rare sugars: metabolic impacts and mechanisms of action: a scoping review (2021)
Journal Article
Smith, A., Avery, A., Ford, R., Yang, Q., Goux, A., Mukherjee, I., Neville, D. C., & Jethwa, P. (2022). Rare sugars: metabolic impacts and mechanisms of action: a scoping review. British Journal of Nutrition, 128(3), 389-406. https://doi.org/10.1017/S0007114521003524

Food manufacturers are under increasing pressure to limit the amount of free sugars in their products. Many have reformulated products to replace sucrose, glucose and fructose with alternative sweeteners, but some of these have been associated with a... Read More about Rare sugars: metabolic impacts and mechanisms of action: a scoping review.

In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review (2021)
Journal Article
Alliband, K. H., Kozhevnikova, S. V., Parr, T., Jethwa, P. H., & Brameld, J. M. (2021). In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review. Frontiers in Physiology, 12, Article 736708. https://doi.org/10.3389/fphys.2021.736708

Vitamin D (VD) deficiency is associated with muscle weakness. A reduction in the incidence of falls in the elderly following VD supplementation and identification of the VD receptor within muscle cells suggests a direct effect of VD on muscle, but li... Read More about In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review.

Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (PLoS ONE 12:2: (e0172724) DOI: 10.1371/journal.pone.0172724) (2017)
Journal Article
Lewis, J. E., Brameld, J. M., Hill, P., Cocco, C., Noli, B., Ferri, G. L., Barrett, P., Ebling, F. J., & Jethwa, P. H. (2017). Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (PLoS ONE 12:2: (e0172724) DOI: 10.1371/journal.pone.0172724). PLoS ONE, 12(7), https://doi.org/10.1371/journal.pone.0182594

© 2017 Lewis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cred... Read More about Correction: Hypothalamic over-expression of VGF in the Siberian hamster increases energy expenditure and reduces body weight gain (PLoS ONE 12:2: (e0172724) DOI: 10.1371/journal.pone.0172724).

Thyroid hormone and vitamin D regulate VGF expression and promoter activity (2016)
Journal Article
Lewis, J. E., Brameld, J. M., Hill, P., Wilson, D., Barrett, P., Ebling, F. J., & Jethwa, P. H. (2016). Thyroid hormone and vitamin D regulate VGF expression and promoter activity. Journal of Molecular Endocrinology, 56(2), 123-134. https://doi.org/10.1530/JME-15-0224

The Siberian hamster (Phodopus sungorus) survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. Hypothalamic tanycytes are pivotal for this process. In these cells, s... Read More about Thyroid hormone and vitamin D regulate VGF expression and promoter activity.