Outputs (43)

Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant? (2003)
Journal Article
Whiteman, M., Rose, P., & Halliwell, B. (2003). Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant?. Biochemical and Biophysical Research Communications, 303(4), 1217-1224. https://doi.org/10.1016/S0006-291X%2803%2900503-5

Acute and chronic inflammation result in increased nitrogen monoxide (̇NO) formation and the accumulation of nitrite (NO2-). Neutrophils stimulated by various inflammatory mediators release myeloperoxidase to produce the cytotoxic agent hypochlorous... Read More about Inhibition of hypochlorous acid-induced oxidative reactions by nitrite: Is nitrite an antioxidant?.

Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and α1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa (2003)
Journal Article
Rose, P., Widder, S., Looft, J., Pickenhagen, W., Ong, C. N., & Whiteman, M. (2003). Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and α1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa. Biochemical and Biophysical Research Communications, 302(2), 397-402. https://doi.org/10.1016/S0006-291X%2803%2900193-1

Peroxynitrite formation in vivo is implicated in numerous human diseases and there is considerable interest in the use of antioxidants and natural products such as thiols as "peroxynitrite scavengers". We therefore investigated the effects of a recen... Read More about Inhibition of peroxynitrite-mediated cellular toxicity, tyrosine nitration, and α1-antiproteinase inactivation by 3-mercapto-2-methylpentan-1-ol, a novel compound isolated from Allium cepa.

7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes (2000)
Journal Article
Rose, P., Faulkner, K., Williamson, G., & Mithen, R. (2000). 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes. Carcinogenesis, 21(11), 1983-1988. https://doi.org/10.1093/carcin/21.11.1983

Watercress is an exceptionally rich dietary source of β-phenylethyl isothiocyanate (PEITC). This compound inhibits phase I enzymes, which are responsible for the activation of many carcinogens in animals, and induces phase II enzymes, which are assoc... Read More about 7-Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes.