Outputs (43)

Diet and Hydrogen Sulfide Production in Mammals (2020)
Journal Article
Rose, P., Moore, P. K., Whiteman, M., Kirk, C., & Zhu, Y.-Z. (2021). Diet and Hydrogen Sulfide Production in Mammals. Antioxidants and Redox Signaling, 34(17), 1378-1393. https://doi.org/10.1089/ars.2020.8217

Significance: In recent times, it has emerged that some dietary sulfur compounds can act on mammalian cell signaling systems via their propensity to release hydrogen sulfide (H2S). H2S plays important biochemical and physiological roles in the heart,... Read More about Diet and Hydrogen Sulfide Production in Mammals.

Epigenetics and Vascular Senescence–Potential New Therapeutic Targets? (2020)
Journal Article
Ding, Q., Shao, C., Rose, P., & Zhu, Y. Z. (2020). Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?. Frontiers in Pharmacology, 11, Article 535395. https://doi.org/10.3389/fphar.2020.535395

© Copyright © 2020 Ding, Shao, Rose and Zhu. Epigenetics is defined as the heritable alterations of gene expression without changes to the coding sequence of DNA. These alterations are mediated by processes including DNA methylation, histone modifica... Read More about Epigenetics and Vascular Senescence–Potential New Therapeutic Targets?.

A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway (2019)
Journal Article
Hieu Tran, B., Yu, Y., Chang, L., Tan, B., Jia, W., Xiong, Y., Dai, T., Zhong, R., Zhang, W., Minh Le, V., Rose, P., Wang, Z., Mao, Y., & Zhun Zhu, Y. (2019). A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway. International Journal of Nanomedicine, 2019:14, 10061-10077. https://doi.org/10.2147/IJN.S216667

Purpose: S-propargyl-cysteine (SPRC; alternatively known as ZYZ-802) is a novel modulator of endogenous tissue H2S concentrations with known cardioprotective and anti-inflammatory effects. However, its rapid metabolism and excretion have limited its... Read More about A novel liposomal S-propargyl-cysteine: a sustained release of hydrogen sulfide reducing myocardial fibrosis via TGF-β1/Smad pathway.

An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic (2019)
Journal Article
Rose, P., Moore, P. K., Whiteman, M., & Zhu, Y.-Z. (2019). An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic. Molecules, 24(21), Article 4006. https://doi.org/10.3390/molecules24214006

Alliums and allied plant species are rich sources of sulfur compounds that have effects on vascular homeostasis and the control of metabolic systems linked to nutrient metabolism in mammals. In view of the multiple biological effects ascribed to thes... Read More about An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic.

ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation (2017)
Journal Article
Luo, S., Hieu, T. B., Ma, F., Yu, Y., Cao, Z., Wang, M., Wu, W., Mao, Y., Rose, P., Law, B. Y.-K., & Zhu, Y. Z. (in press). ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation. Scientific Reports, 7, Article 43242. https://doi.org/10.1038/srep43242

Selective treatments for myocardial infarction (MI) induced cardiac fibrosis are lacking. In this study, we focus on the therapeutic potential of a synthetic cardio-protective agent named ZYZ-168 towards MI-induced cardiac fibrosis and try to reveal... Read More about ZYZ-168 alleviates cardiac fibrosis after myocardial infarction through inhibition of ERK1/2-dependent ROCK1 activation.

H2S biosynthesis and catabolism: new insights from molecular studies (2016)
Journal Article
Rose, P., Moore, P. K., & Zhu, Y. Z. (2017). H2S biosynthesis and catabolism: new insights from molecular studies. Cellular and Molecular Life Sciences, 74(8), 1391-1412. https://doi.org/10.1007/s00018-016-2406-8

Hydrogen sulfide (H2S) has profound biological effects within living organisms and is now increasingly being considered alongside other gaseous signalling molecules, such as nitric oxide (NO) and carbon monoxide (CO). Conventional use of pharmacologi... Read More about H2S biosynthesis and catabolism: new insights from molecular studies.

GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule (2015)
Book Chapter
Rose, P., Dymock, B. W., & Moore, P. K. (2015). GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule. In Hydrogen Sulfide in Redox Biology, Part A (143-167). Elsevier. https://doi.org/10.1016/bs.mie.2014.11.014

Hydrogen sulfide (H2S) is now recognized as the so called "third gasotransmitter" taking its place alongside nitric oxide and carbon monoxide. In recent years, H2S has been reported to exhibit a diverse range of pharmacological effects in biological... Read More about GYY4137, a Novel Water-Soluble, H2S-Releasing Molecule.

Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans (2014)
Journal Article
Qabazard, B., Li, L., Gruber, J., Peh, M. T., Ng, L. F., Kumar, S. D., Rose, P., Tan, C. H., Dymock, B. W., Wei, F., Swain, S. C., Halliwell, B., Stürzenbaum, S. R., & Moore, P. K. (2014). Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans. Antioxidants and Redox Signaling, 20(16), 2621-2630. https://doi.org/10.1089/ars.2013.5448

Aims:

To investigate the role of endogenous hydrogen sulfide (H 2S) in the control of aging and healthspan of Caenorhabditis elegans.

Results:

We show that the model organism, C. elegans, synthesizes H 2S. Three H2S-synthesizing enzymes a... Read More about Hydrogen Sulfide Is an Endogenous Regulator of Aging in Caenorhabditis elegans.

Future climate alleviates stress impact on grassland productivity through altered antioxidant capacity (2013)
Journal Article
Naudts, K., Van den Berge, J., Farfan, E., Rose, P., AbdElgawad, H., Ceulemans, R., Janssens, I. A., Asard, H., & Nijs, I. (2014). Future climate alleviates stress impact on grassland productivity through altered antioxidant capacity. Environmental and Experimental Botany, 99, 150-158. https://doi.org/10.1016/j.envexpbot.2013.11.003

Predicting future ecosystem functioning requires a mechanistic understanding of how plants cope with different stressors under future climate conditions with elevated CO2 concentrations and warmer temperatures. Nonetheless, studies of stress response... Read More about Future climate alleviates stress impact on grassland productivity through altered antioxidant capacity.

Hydrogen sulfide and cell signaling (2011)
Journal Article
Li, L., Rose, P., & Moore, P. K. (2011). Hydrogen sulfide and cell signaling. Annual Review of Pharmacology and Toxicology, 51, 169-187. https://doi.org/10.1146/annurev-pharmtox-010510-100505

Hydrogen sulfide (H2S) is a gaseous mediator synthesized from cysteine by cystathionine λ lyase (CSE) and other naturally occurring enzymes. Pharmacological experiments usingH2S donors and genetic experiments using CSE knockout mice suggest important... Read More about Hydrogen sulfide and cell signaling.