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An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic

Rose, Peter; Moore, Philip Keith; Whiteman, Matthew; Zhu, Yi-Zhun

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Authors

PETER ROSE Peter.Rose@nottingham.ac.uk
Assistant Professor

Philip Keith Moore

Matthew Whiteman

Yi-Zhun Zhu



Abstract

Alliums and allied plant species are rich sources of sulfur compounds that have effects on vascular homeostasis and the control of metabolic systems linked to nutrient metabolism in mammals. In view of the multiple biological effects ascribed to these sulfur molecules, researchers are now using these compounds as inspiration for the synthesis and development of novel sulfur-based therapeutics. This research has led to the chemical synthesis and biological assessment of a diverse array of sulfur compounds representative of derivatives of S-alkenyl-L-cysteine sulfoxides, thiosulfinates, ajoene molecules, sulfides, and S-allylcysteine. Many of these synthetic derivatives have potent antimicrobial and anticancer properties when tested in preclinical models of disease. Therefore, the current review provides an overview of advances in the development and biological assessment of synthetic analogs of allium-derived sulfur compounds.

Citation

Rose, P., Moore, P. K., Whiteman, M., & Zhu, Y. (2019). An Appraisal of Developments in Allium Sulfur Chemistry: Expanding the Pharmacopeia of Garlic. Molecules, 24(21), Article 4006. https://doi.org/10.3390/molecules24214006

Journal Article Type Review
Acceptance Date Oct 30, 2019
Online Publication Date Nov 5, 2019
Publication Date Nov 1, 2019
Deposit Date Nov 15, 2019
Publicly Available Date Mar 29, 2024
Journal Molecules
Electronic ISSN 1420-3049
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 24
Issue 21
Article Number 4006
DOI https://doi.org/10.3390/molecules24214006
Keywords Allium; Anticancer; Garlic; Gaseous mediators; Hydrogen sulfide; Sulfur compounds
Public URL https://nottingham-repository.worktribe.com/output/3288512
Publisher URL https://www.mdpi.com/1420-3049/24/21/4006

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