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The role of GABA in semantic memory and its neuroplasticity (2025)
Journal Article
Jung, J., Williams, S., Lambon Ralph, M. A., & Lambon Ralph, M. A. (2025). The role of GABA in semantic memory and its neuroplasticity. eLife, 12, Article RP91771. https://doi.org/10.7554/eLife.91771.4

A fundamental challenge in neuroscience is understanding neural functioning and plasticity of the brain. The anterior temporal lobe (ATL) is a hub for semantic memory, which generates coherent conceptual representations. GABAergic inhibition plays a... Read More about The role of GABA in semantic memory and its neuroplasticity.

Impact of Apolipoprotein E ε4 in Alzheimer’s Disease: A Meta-Analysis of Voxel-Based Morphometry Studies (2024)
Journal Article
Bailey, M., Ilchovska, Z. G., Hosseini, A. A., & Jung, J. (2024). Impact of Apolipoprotein E ε4 in Alzheimer’s Disease: A Meta-Analysis of Voxel-Based Morphometry Studies. Journal of Clinical Neurology, 20(5), 469-477. https://doi.org/10.3988/jcn.2024.0176

Background and Purpose

Alzheimer’s disease (AD) is the most-prevalent form of dementia and imposes substantial burdens at the personal and societal levels. The apolipoprotein E (APOE) ε4 allele is a genetic factor known to increase AD risk and ex... Read More about Impact of Apolipoprotein E ε4 in Alzheimer’s Disease: A Meta-Analysis of Voxel-Based Morphometry Studies.

Intermittent theta burst stimulation with synchronised transcranial alternating current stimulation leads to enhanced frontal theta oscillations and a positive shift in emotional bias (2024)
Journal Article
Briley, P. M., Boutry, C., Webster, L., Veniero, D., Harvey-Seutcheu, C., Jung, J., Liddle, P. F., & Morriss, R. (2024). Intermittent theta burst stimulation with synchronised transcranial alternating current stimulation leads to enhanced frontal theta oscillations and a positive shift in emotional bias. Imaging Neuroscience, 2, 1-14. https://doi.org/10.1162/imag_a_00073

Repetitive transcranial magnetic stimulation (rTMS), delivered to left dorsolateral prefrontal cortex, is an FDA-approved, and NICE-recommended, neuromodulation therapy for major depressive disorder (MDD). However, there is considerable inter-individ... Read More about Intermittent theta burst stimulation with synchronised transcranial alternating current stimulation leads to enhanced frontal theta oscillations and a positive shift in emotional bias.

Theta Burst Stimulation of the Human Motor Cortex Modulates Secondary Hyperalgesia to Punctate Mechanical Stimuli (2023)
Journal Article
Hodkinson, D. J., Drabek, M. M., Jung, J., Lankappa, S. T., & Auer, D. P. (2024). Theta Burst Stimulation of the Human Motor Cortex Modulates Secondary Hyperalgesia to Punctate Mechanical Stimuli. Neuromodulation, 27(5), 812-823. https://doi.org/10.1016/j.neurom.2023.10.007

Objectives: Many chronic pain conditions show evidence of dysregulated synaptic plasticity, including the development and maintenance of central sensitization. This provides a strong rationale for neuromodulation therapies for the relief of chronic p... Read More about Theta Burst Stimulation of the Human Motor Cortex Modulates Secondary Hyperalgesia to Punctate Mechanical Stimuli.

Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study (2022)
Journal Article
Hodkinson, D. J., Jackson, S. R., & Jung, J. (2022). Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study. Frontiers in Pain Research, 3, Article 1005634. https://doi.org/10.3389/fpain.2022.1005634

The ability of non-invasive brain stimulation to induce neuroplasticity and cause long-lasting functional changes is of considerable interest for the reversal of chronic pain and disability. Stimulation of the primary motor cortex (M1) has provided s... Read More about Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study.

Non-invasive brain stimulation modulates GABAergic activity in neurofibromatosis 1 (2022)
Journal Article
Garg, S., Williams, S., Jung, J., Pobric, G., Nandi, T., Lim, B., Vassallo, G., Green, J., Evans, D. G., Stagg, C. J., Parkes, L. M., & Stivaros, S. (2022). Non-invasive brain stimulation modulates GABAergic activity in neurofibromatosis 1. Scientific Reports, 12(1), Article 18297. https://doi.org/10.1038/s41598-022-21907-9

Neurofibromatosis 1 (NF1) is a single-gene disorder associated with cognitive phenotypes common to neurodevelopmental conditions such as autism. GABAergic dysregulation underlies working memory impairments seen in NF1. This mechanistic experimental s... Read More about Non-invasive brain stimulation modulates GABAergic activity in neurofibromatosis 1.

Neurochemical profiles of the anterior temporal lobe predict response of repetitive transcranial magnetic stimulation on semantic processing (2022)
Journal Article
Jung, J. Y., Williams, S. R., Nezhad, F. S., & Lambon Ralph, M. A. (2022). Neurochemical profiles of the anterior temporal lobe predict response of repetitive transcranial magnetic stimulation on semantic processing. NeuroImage, 258, Article 119386. https://doi.org/10.1016/j.neuroimage.2022.119386

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique used to modulate cortical excitability in the human brain. However, one major challenge with rTMS is that the responses to stimulation are highly variable across individu... Read More about Neurochemical profiles of the anterior temporal lobe predict response of repetitive transcranial magnetic stimulation on semantic processing.

Distinct but cooperating brain networks supporting semantic cognition (2022)
Journal Article
Jung, J., & Lambon Ralph, M. (2023). Distinct but cooperating brain networks supporting semantic cognition. Cerebral Cortex, 33(5), 2021-2036. https://doi.org/10.1093/cercor/bhac190

Semantic cognition is a complex multifaceted brain function involving multiple processes including sensory, semantic, and domain-general cognitive systems. However, it remains unclear how these systems cooperate with each other to achieve effective s... Read More about Distinct but cooperating brain networks supporting semantic cognition.