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Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study

Hodkinson, Duncan J.; Jackson, Stephen R.; Jung, JeYoung

Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study Thumbnail


Authors

STEPHEN JACKSON stephen.jackson@nottingham.ac.uk
Professor of Cognitive Neuroscience



Abstract

The ability of non-invasive brain stimulation to induce neuroplasticity and cause long-lasting functional changes is of considerable interest for the reversal of chronic pain and disability. Stimulation of the primary motor cortex (M1) has provided some of the most encouraging after-effects for therapeutic purposes, but little is known about its underlying mechanisms. In this study we combined transcranial Direct Current Stimulation (tDCS) and fMRI to measure changes in task-specific activity and interregional functional connectivity between M1 and the whole brain. Using a randomized counterbalanced sham-controlled design, we applied anodal and cathodal tDCS stimulation over the left M1. In agreement with previous studies, we demonstrate that tDCS applied to the target region induces task-specific facilitation of local brain activity after anodal tDCS, with the stimulation effects having a negative relationship to the resting motor threshold. Beyond the local effects, tDCS also induced changes in multiple downstream regions distinct from the motor system that may be important for therapeutic efficacy, including the operculo-insular and cingulate cortex. These results offer opportunities to improve outcomes of tDCS for the individual patient based on the degree of presumed neuroplasticity. Further research is still warranted to address the optimal stimulation targets and parameters for those with disease-specific symptoms of chronic pain.

Journal Article Type Article
Acceptance Date Nov 7, 2022
Online Publication Date Nov 25, 2022
Publication Date Nov 25, 2022
Deposit Date Jan 24, 2023
Publicly Available Date Jan 26, 2023
Journal Frontiers in Pain Research
Print ISSN 2673-561X
Electronic ISSN 2673-561X
Publisher Frontiers Media SA
Peer Reviewed Peer Reviewed
Volume 3
Article Number 1005634
DOI https://doi.org/10.3389/fpain.2022.1005634
Keywords Pain Research, primary motor cortex, motor, tDCS, plasticity, connectivity, brain networks, fMRI
Public URL https://nottingham-repository.worktribe.com/output/14879943
Publisher URL https://www.frontiersin.org/articles/10.3389/fpain.2022.1005634/full

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Task-dependent plasticity in distributed neural circuits after transcranial direct current stimulation of the human motor cortex: A proof-of-concept study (6.8 Mb)
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.





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