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Outputs (19)

Supramolecular nucleoside-based gel: molecular dynamics simulation and characterization of its nanoarchitecture and self-assembly mechanism (2018)
Journal Article
Angelerou, M. G., Frederix, P. W., Wallace, M., Yang, B., Rodger, A., Adams, D. J., Marlow, M., & Zelzer, M. (2018). Supramolecular nucleoside-based gel: molecular dynamics simulation and characterization of its nanoarchitecture and self-assembly mechanism. Langmuir, 34(23), https://doi.org/10.1021/acs.langmuir.8b00646

Among the diversity of existing supramolecular hydrogels, nucleic acid-based hydrogels are of particular interest for potential drug delivery and tissue engineering applications because of their inherent biocompatibility. Hydrogel performance is dire... Read More about Supramolecular nucleoside-based gel: molecular dynamics simulation and characterization of its nanoarchitecture and self-assembly mechanism.

Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation (2016)
Journal Article
Roberts, J., Sahoo, J., McNamara, L., Burgess, K., Yang, J., Alakpa, E., Anderson, H., Hay, J., Turner, L.-A., Yarwood, S., Zelzer, M., Oreffo, R., Ulijn, R., & Dalby, M. (2016). Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation. ACS Nano, 10(7), 6667-6679. https://doi.org/10.1021/acsnano.6b01765

Out of their niche environment, adult stem cells, such as mesenchymal stem cells (MSCs), spontaneously differentiate. This makes both studying these important regenerative cells and growing large numbers of stem cells for clinical use challenging. Tr... Read More about Dynamic surfaces for the study Of mesenchymal stem cell growth through adhesion regulation.

Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks (2015)
Journal Article
Van Nuffel, S., Parmenter, C. D., Scurr, D. J., Russell, N. A., & Zelzer, M. (in press). Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks. Analyst, 141(1), https://doi.org/10.1039/c5an01743b

Advanced data analysis tools are crucial for the application of ToF-SIMS analysis to biological samples. Here, we demonstrate that by using a training set approach principal components analysis (PCA) can be performed on large 3D ToF-SIMS images of ne... Read More about Multivariate analysis of 3D ToF-SIMS images: method validation and application to cultured neuronal networks.

3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling (2015)
Journal Article
Taylor, M., Scurr, D., Lutolf, M., Buttery, L. D., Zelzer, M., & Alexander, M. R. (2015). 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling. Biointerphases, 11(2), Article 02A301. https://doi.org/10.1116/1.4928209

Hydrogels have been used extensively in bioengineering as artificial cell culture supports. Investigation of the interrelationship between cellular response to the hydrogel and its chemistry ideally requires methods that allow characterization withou... Read More about 3D chemical characterization of frozen hydrated hydrogels using ToF-SIMS with argon cluster sputter depth profiling.

Responsive cell–material interfaces (2015)
Journal Article
Dhowre, H. S., Rajput, S., Russell, N. A., & Zelzer, M. (2015). Responsive cell–material interfaces. Nanomedicine, 10(5), https://doi.org/10.2217/nnm.14.225

Major design aspects for novel biomaterials are driven by the desire to mimic more varied and complex properties of a natural cellular environment with man-made materials. The development of stimulus responsive materials makes considerable contributi... Read More about Responsive cell–material interfaces.

Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides (2014)
Journal Article
Krishna Mohan Nalluri, S., Shivarova, N., Kanibolotsky, A. L., Zelzer, M., Gupta, S., Frederix, P. W., Skabara, P. J., Gleskova, H., & Ulijn, R. V. (2014). Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides. Langmuir, 30(41), 12429-12437. https://doi.org/10.1021/la503459y

We demonstrate the nonaqueous self-assembly of a low-molecular-mass organic gelator based on an electroactive p-type tetrathiafulvalene (TTF)–dipeptide bioconjugate. We show that a TTF moiety appended with diphenylalanine amide derivative (TTF-FF-NH2... Read More about Conducting nanofibers and organogels derived from the self-assembly of tetrathiafulvalene-appended dipeptides.

Interface and surface analysis for pharmaceutical applications: challenges and recent advances (2014)
Journal Article
Piggott, M. J., & Zelzer, M. (2014). Interface and surface analysis for pharmaceutical applications: challenges and recent advances. Chimica Oggi, 32(5),

Innovation in R&D is a key target for the pharmaceutical sector to address some of the challenges it currently faces. This review discusses these challenges in the context of pharmaceutically relevant surfaces and interfaces. The surface properties o... Read More about Interface and surface analysis for pharmaceutical applications: challenges and recent advances.