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PLGA-PEG-PLGA hydrogels induce cytotoxicity in conventional in vitro assays (2024)
Journal Article
Stewart, C. L., Hook, A. L., Zelzer, M., Marlow, M., & Piccinini, A. M. (2024). PLGA-PEG-PLGA hydrogels induce cytotoxicity in conventional in vitro assays. Cell Biochemistry and Function, 42(5), Article e4097. https://doi.org/10.1002/cbf.4097

We identified that PLGA-PEG-PLGA hydrogels, which have been used in human clinical trials and possess a demonstrable safety profile, induced significant cytotoxicity in conventional in vitro assays. This major contradiction may lead to inconsistent a... Read More about PLGA-PEG-PLGA hydrogels induce cytotoxicity in conventional in vitro assays.

Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures (2024)
Journal Article
Schindl, A., Hagen, M. L., Cooley, I., Jäger, C. M., Warden, A. C., Zelzer, M., Allers, T., & Croft, A. K. (2024). Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures. RSC Sustainability, 2(9), 2559-2580. https://doi.org/10.1039/d3su00412k

Biocatalysis in ionic liquids enables novel routes for bioprocessing. Enzymes derived from extremophiles promise greater stability and activity under ionic liquid (IL) influence. Here, we probe the enzyme alcohol dehydrogenase 2 from the halophilic a... Read More about Ion-combination specific effects driving the enzymatic activity of halophilic alcohol dehydrogenase 2 from Haloferax volcanii in aqueous ionic liquid solvent mixtures.

Cellular and microenvironmental cues that promote macrophage fusion and foreign body response (2024)
Journal Article
Stewart, C. L., Marlow, M., Zelzer, M., Hook, A. L., & Piccinini, A. M. (in press). Cellular and microenvironmental cues that promote macrophage fusion and foreign body response. Frontiers in Immunology, 15, Article 1411872. https://doi.org/10.3389/fimmu.2024.1411872

During the foreign body response (FBR), macrophages fuse to form foreign body giant cells (FBGCs). Modulation of FBGC formation can prevent biomaterial degradation and loss of therapeutic efficacy. However, the microenvironmental cues that dictate FB... Read More about Cellular and microenvironmental cues that promote macrophage fusion and foreign body response.