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Outputs (14)

A virological view of tenascin-C in infection (2022)
Journal Article
Zuliani-Alvarez, L., & Piccinini, A. M. (2023). A virological view of tenascin-C in infection. American Journal of Physiology - Cell Physiology, 324(1), C1-C9. https://doi.org/10.1152/ajpcell.00333.2022

Tenascin-C is a large extracellular matrix glycoprotein with complex, not yet fully unveiled roles. Its context- and structure-dependent modus operandi renders tenascin-C a puzzling protein. Since its discovery ∼40 years ago, research into tenascin-C... Read More about A virological view of tenascin-C in infection.

miR-155-3p: processing by-product or rising star in immunity and cancer? (2022)
Journal Article
Dawson, O., & Piccinini, A. M. (2022). miR-155-3p: processing by-product or rising star in immunity and cancer?. Open Biology, 12(5), 843-854. https://doi.org/10.1098/rsob.220070

MicroRNAs (miRNAs) are key players in gene regulation that target specific mRNAs for degradation or translational repression. Each miRNA is synthesized as a miRNA duplex comprising two strands (5p and 3p). However, only one of the two strands becomes... Read More about miR-155-3p: processing by-product or rising star in immunity and cancer?.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., …Kehoe, O. (2022). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), Article 126. https://doi.org/10.3390/ijms23010126

Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs in an an... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders (2020)
Journal Article
Goh, J. Y., O'Sullivan, S. E., Shortall, S. E., Zordan, N., Piccinini, A. M., Potter, H. G., …King, M. V. (2020). Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders. Brain, Behavior, and Immunity, 89, 100-117. https://doi.org/10.1016/j.bbi.2020.05.076

© 2020 Elsevier Inc. Many psychiatric illnesses have a multifactorial etiology involving genetic and environmental risk factors that trigger persistent neurodevelopmental impairments. Several risk factors have been individually replicated in rodents,... Read More about Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat ‘dual-hit’ model for neurodevelopmental disorders.

The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis (2019)
Journal Article
Ashraf, S., Radhi, M., Gowler, P., Burston, J. J., Gandhi, R. D., Thorn, G. J., …Chapman, V. (2019). The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Scientific Reports, 9(1), 1-17. https://doi.org/10.1038/s41598-019-41140-1

Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a role of polyadenylation in OA... Read More about The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.

A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens (2018)
Journal Article
Tomlin, H., & Piccinini, A. M. (2018). A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens. Immunology, 155(2), 186-201. https://doi.org/10.1111/imm.12972

The role of the host extracellular matrix (ECM) in infection tends to be neglected. However, the complex interactions between invading pathogens, host tissues and immune cells occur in the context of the ECM. On the pathogen side, a variety of surfac... Read More about A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens.

Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis (2017)
Journal Article
Kay, A. G., Long, G., Tyler, G., Stefan, A., Broadfoot, S. J., Piccinini, A. M., …Kehoe, O. (2017). Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis. Scientific Reports, 7, Article 18019. https://doi.org/10.1038/s41598-017-18144-w

We evaluated the therapeutic potential of mesenchymal stem cell-conditioned medium (CM-MSC) as an alternative to cell therapy in an antigen-induced model of arthritis (AIA). Disease severity and cartilage loss were evaluated by histopathological anal... Read More about Mesenchymal stem cell-conditioned medium reduces disease severity and immune responses in inflammatory arthritis.

Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers (2017)
Journal Article
Zuliani-Alvarez, L., Marzeda, A. M., Deligne, C., Schwenzer, A., McCann, F. E., Marsden, B. D., …Midwood, K. S. (2017). Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers. Nature Communications, 8(1), Article 1595. https://doi.org/10.1038/s41467-017-01718-7

© 2017 The Author(s). Pattern recognition underpins innate immunity; the accurate identification of danger, including infection, injury, or tumor, is key to an appropriately targeted immune response. Pathogen detection is increasingly well defined me... Read More about Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.

Screening for novel endogenous inflammatory stimuli using the secreted embryonic alkaline phosphatase NF-?B reporter assay (2017)
Journal Article
Zuliani-Alvarez, L., Piccinini, A. M., & Midwood, K. S. (2017). Screening for novel endogenous inflammatory stimuli using the secreted embryonic alkaline phosphatase NF-?B reporter assay. Bio-protocol, 7(7), https://doi.org/10.21769/BioProtoc.2220

An immune response can be activated by pathogenic stimuli, as well as endogenous danger signals, triggering the activation of pattern recognition receptors and initiating signalling cascades that lead to inflammation. This method uses THP1-Blue™ cell... Read More about Screening for novel endogenous inflammatory stimuli using the secreted embryonic alkaline phosphatase NF-?B reporter assay.