Outputs (34)

In vivo analysis of hybrid hydrogels containing dual growth factor combinations, and skeletal stem cells under mechanical stimulation for bone repair (2024)
Journal Article
Gothard, D., Rotherham, M., Smith, E. L., Kanczler, J. M., Henstock, J., Wells, J. A., Roberts, C. A., Qutachi, O., Peto, H., Rashidi, H., Rojo, L., White, L. J., Stevens, M. M., El Haj, A. J., Rose, F. R., & Oreffo, R. O. (2024). In vivo analysis of hybrid hydrogels containing dual growth factor combinations, and skeletal stem cells under mechanical stimulation for bone repair. Mechanobiology in Medicine, 2(4), Article 100096. https://doi.org/10.1016/j.mbm.2024.100096

Bone tissue engineering requires a combination of materials, cells, growth factors and mechanical cues to recapitulate bone formation. In this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with sk... Read More about In vivo analysis of hybrid hydrogels containing dual growth factor combinations, and skeletal stem cells under mechanical stimulation for bone repair.

Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community (2024)
Journal Article
Dalby, M. J., Pekovic‐Vaughan, V., Shanley, D. P., Swift, J., White, L. J., & Canty‐Laird, E. G. (2024). Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community. BioEssays, 46(5), Article 2300223. https://doi.org/10.1002/bies.202300223

Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional network of macromolecules that provides our tissues with structure and... Read More about Strengths and opportunities in research into extracellular matrix ageing: A consultation with the ECMage research community.

Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves (2022)
Journal Article
Kellaway, S. C., Roberton, V., Jones, J. N., Loczenski, R., Phillips, J. B., & White, L. J. (2023). Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves. Acta Biomaterialia, 157, 124-136. https://doi.org/10.1016/j.actbio.2022.12.003

Engineered neural tissue (EngNT) promotes in vivo axonal regeneration. Decellularised materials (dECM) are complex biologic scaffolds that can improve the cellular environment and also encourage positive tissue remodelling in vivo. We hypothesised th... Read More about Engineered neural tissue made using hydrogels derived from decellularised tissues for the regeneration of peripheral nerves.

Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease (2022)
Journal Article
Li, X., Li, T., Zhan, F., Cheng, F., Lu, L., Zhang, B., Li, J., Hu, Z., Zhou, S., Jia, Y., Allen, S., White, L., Phillips, J., Zhu, Z., Xu, J., & Yao, H. (2022). Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease. ACS Chemical Neuroscience, 13(23), 3488-3501. https://doi.org/10.1021/acschemneuro.2c00520

Based on a multitarget strategy, a series of novel chromanone-1-benzyl-1,2,3,6-tetrahydropyridin hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation demonstrated that these hybrids exhibited signific... Read More about Design, Synthesis, and Biological Evaluation of Novel Chromanone Derivatives as Multifunctional Agents for the Treatment of Alzheimer's Disease.

Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease (2022)
Journal Article
Li, X., Li, T., Zhang, P., Li, X., Lu, L., Sun, Y., Zhang, B., Allen, S., White, L., Phillips, J., Zhu, Z., Yao, H., & Xu, J. (2022). Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease. European Journal of Medicinal Chemistry, 244, Article 114841. https://doi.org/10.1016/j.ejmech.2022.114841

Based on the multitarget strategy, a series of novel clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine hybrids were identified for the potential treatment of Alzheimer's disease (AD). Biological evaluation in vitro revealed that these hybrids exhibited... Read More about Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease.

Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs (2022)
Journal Article
Sanjuan-Alberte, P., Whitehead, C., Jones, J. N., Silva, J. C., Carter, N., Kellaway, S., Hague, R. J., Cabral, J. M., Ferreira, F. C., White, L. J., & Rawson, F. J. (2022). Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs. iScience, 25(7), Article 104552. https://doi.org/10.1016/j.isci.2022.104552

Conductive hydrogels are emerging as promising materials for bioelectronic applications as they minimize the mismatch between biological and electronic systems. We propose a strategy to bioprint biohybrid conductive bioinks based on decellularized ex... Read More about Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs.

Ovarian extracellular matrix‐based hydrogel for human ovarian follicle survival in vivo: A pilot work (2021)
Journal Article
Chiti, M., Vanacker, J., Ouni, E., Tatic, N., Viswanath, A., des Rieux, A., Dolmans, M., White, L. J., & Amorim, C. A. (2022). Ovarian extracellular matrix‐based hydrogel for human ovarian follicle survival in vivo: A pilot work. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 110(5), 1012-1022. https://doi.org/10.1002/jbm.b.34974

To successfully assemble a bio-engineered ovary, we need to create a three-dimensional matrix able to accommodate isolated follicles and cells. The goal of this study was to develop an extracellular matrix hydrogel (oECM) derived from decellularized... Read More about Ovarian extracellular matrix‐based hydrogel for human ovarian follicle survival in vivo: A pilot work.

Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model (2021)
Journal Article
Markides, H., Foster, N. C., McLaren, J. S., Hopkins, T., Black, C., Oreffo, R. O. C., Scammell, B. E., Echevarria, I., White, L. J., & El Haj, A. J. (2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. Cells, 10(7), Article 1776. https://doi.org/10.3390/cells10071776

The ovine critical-sized defect model provides a robust preclinical model for testing tissue-engineered constructs for use in the treatment of non-union bone fractures and severe trauma. A critical question in cell-based therapies is understanding th... Read More about Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model.

Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function (2020)
Journal Article
Quijano, L. M., Naranjo, J. D., El-Mossier, S. O., Turner, N. J., Pineda Molina, C., Bartolacci, J., Zhang, L., White, L., Li, H., & Badylak, S. F. (2020). Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function. Tissue Engineering Part C Methods, 26(10), 528-540. https://doi.org/10.1089/ten.tec.2020.0243

Identification of matrix-bound nanovesicles (MBV) as ubiquitous components of the extracellular matrix (ECM) raises questions regarding their biologic functions and their potential theranostic application. Unlike liquid-phase extracellular vesicles (... Read More about Matrix-Bound Nanovesicles: The Effects of Isolation Method upon Yield, Purity, and Function.

Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold (2020)
Journal Article
Black, C., Kanczler, J., de Andrés, M., White, L., Savi, F., Bas, O., Saifzadeh, S., Henkel, J., Zannettino, A., Gronthos, S., Woodruff, M., Hutmacher, D., & Oreffo, R. (2020). Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold. Biomaterials, 247, Article 119998. https://doi.org/10.1016/j.biomaterials.2020.119998

Many skeletal tissue regenerative strategies centre around the multifunctional properties of bone marrow derived stromal cells (BMSC) or mesenchymal stem/stromal cells (MSC)/bone marrow derived skeletal stem cells (SSC). Specific identification of th... Read More about Characterisation and evaluation of the regenerative capacity of Stro-4+ enriched bone marrow mesenchymal stromal cells using bovine extracellular matrix hydrogel and a novel biocompatible melt electro-written medical-grade polycaprolactone scaffold.