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Outputs (14)

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages (2016)
Journal Article
Piccinini, A. M., Zuliani-Alvarez, L., Lim, J. M., & Midwood, K. S. (2016). Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages. Science Signaling, 9(443), ra86-ra86. https://doi.org/10.1126/scisignal.aaf3596

Macrophages exhibit a phenotypic plasticity that enables them to orchestrate specific immune responses to distinct threats. However, the factors that control macrophage behaviour in a context dependent manner are not well understood. Lipopolysacchari... Read More about Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages.

Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation (2016)
Journal Article
Gschwandtner, M., Piccinini, A. M., Geriza, T., Adage, T., & Kungl, A. (2016). Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation. Neuroscience Letters, 626, 164-173. https://doi.org/10.1016/j.neulet.2016.05.037

© 2016 Elsevier Ireland Ltd. Multiple Sclerosis, a chronic inflammatory demyelinating disease of the central nervous system, involves an increased expression of monocyte chemotactic protein 1 MCP1-/CCL2. For exerting its chemotactic effects, chemokin... Read More about Interfering with the CCL2-glycosaminoglycan axis as a potential approach to modulate neuroinflammation.

Investigating the role of toll-like receptors in models of arthritis (2016)
Journal Article
Piccinini, A. M., Williams, L., McCann, F. E., & Midwood, K. S. (2016). Investigating the role of toll-like receptors in models of arthritis. Methods in Molecular Biology, 1390, 351-381. https://doi.org/10.1007/978-1-4939-3335-8_22

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent synovial inflammation leading to tissue destruction and progressive loss of joint function. Here we describe two methods that can be used to assess the contribution... Read More about Investigating the role of toll-like receptors in models of arthritis.

Illustrating the interplay between the extracellular matrix and microRNAs (2014)
Journal Article
Piccinini, A. M., & Midwood, K. S. (2014). Illustrating the interplay between the extracellular matrix and microRNAs. International Journal of Experimental Pathology, 95(3), 158-180. https://doi.org/10.1111/iep.12079

The discovery of cell surface receptors that bind to extracellular matrix (ECM) components marked a new era in biological research. Since then there has been an increasing appreciation of the importance of studying cells in the context of their extra... Read More about Illustrating the interplay between the extracellular matrix and microRNAs.