Outputs (44)

ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and nextday comprehensive profiling for ultra-rapid tumour diagnosis (2025)
Journal Article
Deacon, S., Cahyani, I., Holmes, N., Fox, G., Munro, R., Wibowo, S., Murray, T., Mason, H., Housley, M., Martin, D., Sharif, A., Patel, A., Goldspring, R., Brandner, S., Sahm, F., Smith, S., Paine, S., & Loose, M. (in press). ROBIN: A unified nanopore-based assay integrating intraoperative methylome classification and nextday comprehensive profiling for ultra-rapid tumour diagnosis. Neuro-Oncology,

The Five Safes RO-Crate: FAIR Digital Objects for Trusted Research Environments for Health Data Research (2025)
Presentation / Conference Contribution
Soiland-Reyes, S., Wheater, S., Giles, T., Couldridge, J., Quinlan, P., & Goble, C. (2025, March). The Five Safes RO-Crate: FAIR Digital Objects for Trusted Research Environments for Health Data Research. Presented at International FAIR Digital Objects Implementation Summit 2024, Berlin

Trusted Research Environments (TREs) are secure locations in which health and other sensitive data are placed and made available for researchers to analyse under strict controls. TRE’s in the UK operate under the Five Safes governance framework of sa... Read More about The Five Safes RO-Crate: FAIR Digital Objects for Trusted Research Environments for Health Data Research.

Comparative judgement modelling to map forced marriage at local levels (2025)
Journal Article
Seymour, R., Nyarko-Agyei, A., McCabe, H., Severn, K., Sirl, D., Kypraios, T., & Taylor, A. (2025). Comparative judgement modelling to map forced marriage at local levels. Annals of Applied Statistics, 19(1), 419-439. https://doi.org/10.1214/24-AOAS1966

Forcing someone into marriage against their will is a violation of their human rights. In 2021, the county of Nottinghamshire, UK, launched a strategy to tackle forced marriage and violence against women and girls. We set out to map the risk of force... Read More about Comparative judgement modelling to map forced marriage at local levels.

Homogeneous catalyst graph neural network: A human-interpretable graph neural network tool for ligand optimization in asymmetric catalysis (2025)
Journal Article
Aguilar-Bejarano, E., Özcan, E., Rit, R. K., Li, H., Lam, H. W., Moore, J. C., Woodward, S., & Figueredo, G. (2025). Homogeneous catalyst graph neural network: A human-interpretable graph neural network tool for ligand optimization in asymmetric catalysis. iScience, 28(3), Article 111881. https://doi.org/10.1016/j.isci.2025.111881

Optimization of metal-ligand asymmetric catalysts is usually done by empirical trials, where the ligand is arbitrarily modified, and the new catalyst is re-evaluated in the lab. This procedure is not efficient and alternative strategies are highly de... Read More about Homogeneous catalyst graph neural network: A human-interpretable graph neural network tool for ligand optimization in asymmetric catalysis.

Data Checking of Asymmetric Catalysis Literature Using a Graph Neural Network Approach (2025)
Journal Article
Aguilar-Bejarano, E., Deorukhkar, V., & Woodward, S. (2025). Data Checking of Asymmetric Catalysis Literature Using a Graph Neural Network Approach. Molecules, 30(2), Article 355. https://doi.org/10.3390/molecules30020355

The range of chemical databases available has dramatically increased in recent years, but the reliability and quality of their data are often negatively affected by human-error fidelity. The size of chemical databases can make manual data curation/ch... Read More about Data Checking of Asymmetric Catalysis Literature Using a Graph Neural Network Approach.

Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study (2024)
Journal Article
Bolton, K. J., Mendez-Villalon, A., Nanji, H., Jia, R., Ayling, K., Figueredo, G., & Vedhara, K. (2024). Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study. Mathematics in Medical and Life Sciences, 1(1), Article 2425096. https://doi.org/10.1080/29937574.2024.2425096

Aim: We use the Remote Assessment of Disease and Relapses platform (RADAR) to collect Bluetooth contact and location data from university students. We test the ability of this technology to objectively capture social interaction, explore the propensi... Read More about Monitoring university student response to social distancing policy during the SARS-CoV-2 pandemic using Bluetooth: the RADAR study.

The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project (2024)
Journal Article
Jefferson, E., Milligan, G., Johnston, J., Mumtaz, S., Cole, C., Best, J., Giles, T. C., Cox, S., Masood, E., Horban, S., Urwin, E., Beggs, J., Chuter, A., Reilly, G., Morris, A., Seymour, D., Hopkins, S., Sheikh, A., & Quinlan, P. (2024). The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project. Journal of Medical Internet Research, 26, Article e50235. https://doi.org/10.2196/50235

The COVID-19-Curated and Open Analysis and Research Platform (CO-CONNECT) project worked with 22 organizations across the United Kingdom to build a federated platform, enabling researchers to instantaneously and dynamically query federated datasets t... Read More about The Challenges and Lessons Learned Building a New UK Infrastructure for Finding and Accessing Population-Wide COVID-19 Data for Research and Public Health Analysis: The CO-CONNECT Project.

PIMMS-Dash: Accessible analysis, interrogation, and visualisation of high-throughput transposon insertion sequencing (TIS) data (2024)
Journal Article
Blanchard, A. M., Taylor, A., Warry, A., Shephard, F., Curwen, A., Leigh, J. A., Emes, R. D., & Egan, S. A. (2024). PIMMS-Dash: Accessible analysis, interrogation, and visualisation of high-throughput transposon insertion sequencing (TIS) data. Computational and Structural Biotechnology Journal, 23, 3780-3783. https://doi.org/10.1016/j.csbj.2024.10.025

Motivation: Current methods for visualising and interrogating high-throughput transposon insertion mutagenesis sequencing (TIS) data requires a significant time investment in learning bioinformatics, often producing static figures that do not facilit... Read More about PIMMS-Dash: Accessible analysis, interrogation, and visualisation of high-throughput transposon insertion sequencing (TIS) data.

Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis (2024)
Journal Article
Ndzo, J., Vuyyuru, S. K., Trimble, T., Yan, K., Figueredo, G., & Moran, G. W. (in press). Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis. Journal of Crohn's and Colitis,

Background & Aims:

Incidence of obesity and Crohn’s disease (CD) is increasing globally. Therefore, understanding any associations between adiposity and disease phenotype is crucial. We aimed explore the relationship between nutritional status me... Read More about Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis.

MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1 (2024)
Journal Article
Downie Ruiz Velasco, A., Parsons, A. L., Heatley, M. C., Martin, A. R., Smart, A. D., Shah, N., & Jopling, C. L. (2024). MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1. Nucleic Acids Research, 52(15), 9210-9229. https://doi.org/10.1093/nar/gkae505

In animals, microRNA (miRNA) biogenesis begins with cotranscriptional cleavage of the primary (pri-)miRNA by the Microprocessor complex. Cotranscriptional splicing has been shown to influence Microprocessor cleavage when miRNAs are hosted in introns... Read More about MicroRNA biogenesis is broadly disrupted by inhibition of the splicing factor SF3B1.