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Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis

Ndzo, Judwin; Vuyyuru, Sudheer K.; Trimble, Thomas; Yan, Kaung; Figueredo, Grazziela; Moran, Gordon W.

Authors

Judwin Ndzo

Sudheer K. Vuyyuru

Thomas Trimble

Kaung Yan



Abstract

Background & Aims:

Incidence of obesity and Crohn’s disease (CD) is increasing globally. Therefore, understanding any associations between adiposity and disease phenotype is crucial. We aimed explore the relationship between nutritional status measured by body mass index (BMI) and phenotypes of CD using a large national recallable data set.

Methods:

Using National Institute for Health and Care Research-IBD Bioresource data base, we retrospectively assessed the relationship between BMI and stenosing CD by logistic regression. BMI was the primary variable of interest; CD behaviour the dependent variable; stenosing CD the primary outcome. Confounders were adjusted for in a multivariate model.

Results:

8,797 patients diagnosed between 1942 and 2020 were included. Mean overall BMI was 26.3kg/m2 (SD5.5). 52.7% had a BMI ≥25kg/m2 (mean 30.2kg/m2, SD 4.5). Majority had inflammatory CD (62.9%) followed by stenosing (25.1%) and penetrating CD (12%). Stenosing and penetrating CD were more common in the <25kg/m2 BMI group (50.7%, 50.3% respectively) p<0.001. Colonic disease location was more common (27.8% vs 24.3%, p=0.001) in patients with high BMI. On univariate analysis, stenosing disease was positively associated with ileal disease location, disease duration, previous surgery, use of infliximab, ustekinumab, vedolizumab, adalimumab and azathioprine but negatively associated with BMI (OR 0.98, 95%CI [0.968-0.99]). On multivariate analyses, BMI remained negatively associated with stenosing CD (OR 0.98, 95%CI [0.97-0.99]); ileal disease location (OR 3.69, 95%CI [3.22-4.24]), adalimumab (OR 1.47, 95%CI [1.30-1.66]), ustekinumab usage (OR 1.51, 95%CI [1.14-2.01] and azathioprine (OR 1.35, 95%CI [1.19-1.53]).

Conclusions:

After multivariate analyses, BMI, ileal disease location and biologic use was negatively associated with a stenosing disease phenotype. This might reflect a change in eating behaviour due to persistent postprandial symptoms related to stenosing disease. Large longitudinal studies are needed to investigate any possible temporal relationship between the obesogenic state and intestinal fibrosis.

Citation

Ndzo, J., Vuyyuru, S. K., Trimble, T., Yan, K., Figueredo, G., & Moran, G. W. (2024). Association between Nutritional Status Assessed by Body Mass Index and Crohn’s Disease Phenotype: A Nation-Wide Analysis. Clinical Nutrition ESPEN, 64, 290-295. https://doi.org/10.1016/j.clnesp.2024.09.033

Journal Article Type Article
Acceptance Date Sep 30, 2024
Online Publication Date Oct 17, 2024
Publication Date 2024-12
Deposit Date Oct 2, 2024
Publicly Available Date Oct 18, 2025
Journal Clinical Nutrition ESPEN
Electronic ISSN 2405-4577
Peer Reviewed Peer Reviewed
Volume 64
Pages 290-295
DOI https://doi.org/10.1016/j.clnesp.2024.09.033
Keywords Crohn`s disease, obesity, stenosing, adiposity.
Public URL https://nottingham-repository.worktribe.com/output/40282726
Publisher URL https://www.sciencedirect.com/science/article/abs/pii/S2405457724013378