Outputs (158)

Controlling the crystal structure of precisely spaced polyethylene-like polyphosphoesters (2020)
Journal Article
Haider, T., Suraeva, O., O’Duill, M. L., Mars, J., Mezger, M., Lieberwirth, I., & Wurm, F. R. (2020). Controlling the crystal structure of precisely spaced polyethylene-like polyphosphoesters. Polymer Chemistry, 11(20), 3404-3415. https://doi.org/10.1039/d0py00272k

Understanding polymer crystallization is important for polyethylene-like materials. A small fraction of monomers with functional groups within the polyethylene chain can act as crystallization “defects”. Such defects can be used to control the crysta... Read More about Controlling the crystal structure of precisely spaced polyethylene-like polyphosphoesters.

CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model (2020)
Journal Article
Ketley, A., Wojciechowska, M., Ghidelli-Disse, S., Bamborough, P., Ghosh, T. K., Morato, M. L., Sedehizadeh, S., Malik, N. A., Tang, Z., Powalowska, P., Tanner, M., Billeter-Clark, R., Trueman, R. C., Geiszler, P. C., Agostini, A., Othman, O., Bösche, M., Bantscheff, M., Rüdiger, M., Mossakowska, D. E., …Brook, J. D. (2020). CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model. Science Translational Medicine, 12(541), Article eaaz2415. https://doi.org/10.1126/scitranslmed.aaz2415

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Myotonic dystrophy type 1 (DM1) is an RNA-based disease with no current treatment.... Read More about CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.

Advances on whole-cell biocatalysis in flow (2020)
Journal Article
Pinto, A., Contente, M. L., & Tamborini, L. (2020). Advances on whole-cell biocatalysis in flow. Current Opinion in Green and Sustainable Chemistry, 25, Article 100343. https://doi.org/10.1016/j.cogsc.2020.04.004

The combination of enabling technologies, such as biocatalysis and flow chemistry, represents an important opportunity to expand the chemical toolbox for the preparation of fine chemicals and pharmaceuticals under ambient and environmentally benign c... Read More about Advances on whole-cell biocatalysis in flow.

Sustainable sorbitol-derived compounds for gelation of the full range of ethanol–water mixtures (2020)
Journal Article
Dizon, G. C., Atkinson, G., Argent, S. P., Santu, L. T., & Amabilino, D. B. (2020). Sustainable sorbitol-derived compounds for gelation of the full range of ethanol–water mixtures. Soft Matter, 16(19), 4640-4654. https://doi.org/10.1039/d0sm00343c

During the development of soft material systems inspired by green chemistry, we show that naturally occurring starting materials can be used to prepare mono- and di-benzylidene sorbitol derivatives. These compounds gelate a range of organic, aqueous... Read More about Sustainable sorbitol-derived compounds for gelation of the full range of ethanol–water mixtures.

C-F bond activation of a perfluorinated ligand leading to nucleophilic fluorination of an organic electrophile (2020)
Journal Article
Morgan, P. J., Hanson-Heine, M. W., Thomas, H. P., Saunders, G. C., Marr, A. C., & Licence, P. (2020). C-F bond activation of a perfluorinated ligand leading to nucleophilic fluorination of an organic electrophile. Organometallics, 39(11), 2116–2124. https://doi.org/10.1021/acs.organomet.0c00176

We report a fluorine transfer reaction in which fluorine from a perfluorinated ligand undergoes C-F bond activation and transfer to an electrophile, resulting in the formation of a new fluorinated product and dimerization of the mono-defluorinated co... Read More about C-F bond activation of a perfluorinated ligand leading to nucleophilic fluorination of an organic electrophile.

Expanding Ligand Space: Preparation, Characterization, and Synthetic Applications of Air-Stable, Odorless Di-tert-alkylphosphine Surrogates (2020)
Journal Article
Barber, T., Argent, S. P., & Ball, L. T. (2020). Expanding Ligand Space: Preparation, Characterization, and Synthetic Applications of Air-Stable, Odorless Di-tert-alkylphosphine Surrogates. ACS Catalysis, 10, 5454-5461. https://doi.org/10.1021/acscatal.0c01414

The di-tert-alkylphosphino motif is common to many best-in-class ligands for late-transition-metal catalysis. However, the structural diversity of these privileged substructures is currently limited by the need to manipulate highly toxic, highly reac... Read More about Expanding Ligand Space: Preparation, Characterization, and Synthetic Applications of Air-Stable, Odorless Di-tert-alkylphosphine Surrogates.

Dewar Benzenoids Discovered in Carbon Nanobelts (2020)
Journal Article
Hanson-Heine, M. W., Rogers, D. M., Woodward, S., & Hirst, J. D. (2020). Dewar Benzenoids Discovered in Carbon Nanobelts. Journal of Physical Chemistry Letters, 11(10), 3769-3772. https://doi.org/10.1021/acs.jpclett.0c01027

© 2020 American Chemical Society. The synthesis of cyclacene nanobelts remains an elusive goal dating back over 60 years. These molecules represent the last unsynthesized building block of carbon nanotubes and may be useful both as seed molecules for... Read More about Dewar Benzenoids Discovered in Carbon Nanobelts.

2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations (2020)
Journal Article
Englezou, G., Kortsen, K., Pacheco, A. A. C., Cavanagh, R., Lentz, J. C., Krumins, E., Sanders‐Velez, C., Howdle, S. M., Nedoma, A. J., & Taresco, V. (2020). 2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations. Journal of Polymer Science, 58(11), 1571-1581. https://doi.org/10.1002/pol.20200183

2‐methyltetrahydrofuran (2‐MeTHF) is a readily available, inexpensive, neoteric, bio‐based solvent. It has been adopted across a wide range of chemical processes including the batch manufacture of fine chemicals, enzymatic polycondensations and ring... Read More about 2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations.

Polyurethanes and Polyallophanates via Sequence-Selective Copolymerization of Epoxides and Isocyanates (2020)
Journal Article
Jurrat, M., Pointer-Gleadhill, B. J., Ball, L. T., Chapman, A., & Adriaenssens, L. (2020). Polyurethanes and Polyallophanates via Sequence-Selective Copolymerization of Epoxides and Isocyanates. Journal of the American Chemical Society, 142(18), 8136-8141. https://doi.org/10.1021/jacs.0c03520

Aryl isocyanates are introduced as comonomers for ring-opening copolymerization (ROCOP) with epoxides. Informed by studies of reaction kinetics, we show that divergent sequence selectivity for AB- and ABB-type copolymers can be achieved with a single... Read More about Polyurethanes and Polyallophanates via Sequence-Selective Copolymerization of Epoxides and Isocyanates.

Use of BODIPY-Labeled ATP Analogues in the Development and Validation of a Fluorescence Polarization-Based Assay for Screening of Kinase Inhibitors (2020)
Journal Article
Moreira, B. P., Armstrong, T., Batista, I. C. A., Clemente Tavares, N., Pires, C. V., de Moraes Mourão, M., Falcone, F. H., & Dekker, L. V. (2020). Use of BODIPY-Labeled ATP Analogues in the Development and Validation of a Fluorescence Polarization-Based Assay for Screening of Kinase Inhibitors. ACS Omega, 5(16), 9064-9070. https://doi.org/10.1021/acsomega.9b03344

Copyright © 2020 American Chemical Society. The screening of compound libraries to identify small-molecule modulators of specific biological targets is crucial in the process for the discovery of novel therapeutics and molecular probes. Considering t... Read More about Use of BODIPY-Labeled ATP Analogues in the Development and Validation of a Fluorescence Polarization-Based Assay for Screening of Kinase Inhibitors.