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Advances on whole-cell biocatalysis in flow

Pinto, Andrea; Contente, Martina Letizia; Tamborini, Lucia

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Authors

Andrea Pinto

Martina Letizia Contente

Lucia Tamborini



Abstract

The combination of enabling technologies, such as biocatalysis and flow chemistry, represents an important opportunity to expand the chemical toolbox for the preparation of fine chemicals and pharmaceuticals under ambient and environmentally benign conditions. Whole cells are considered as the cheapest form of catalyst for bioconversion for many reasons, among which the ready and cheap preparation, no need of expensive cofactor, and the increased enzyme stability because of protective barriers offered by cell compartments. This review highlights some of the most recent advances in the field of biotransformations under flow conditions using whole cells. Different examples are provided where the use of continuous flow techniques enables the development of very efficient processes and multiple reaction steps to be combined into a single continuous operation.

Citation

Pinto, A., Contente, M. L., & Tamborini, L. (2020). Advances on whole-cell biocatalysis in flow. Current Opinion in Green and Sustainable Chemistry, 25, https://doi.org/10.1016/j.cogsc.2020.04.004

Journal Article Type Article
Acceptance Date Apr 8, 2020
Online Publication Date Apr 28, 2020
Publication Date 2020-10
Deposit Date Sep 8, 2020
Publicly Available Date Mar 29, 2024
Journal Current Opinion in Green and Sustainable Chemistry
Print ISSN 2452-2236
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 25
Article Number 100343
DOI https://doi.org/10.1016/j.cogsc.2020.04.004
Keywords Waste Management and Disposal; Process Chemistry and Technology; Chemistry (miscellaneous); Management, Monitoring, Policy and Law; Catalysis
Public URL https://nottingham-repository.worktribe.com/output/4889860
Publisher URL https://www.sciencedirect.com/science/article/abs/pii/S2452223620300304

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