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2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations

Englezou, Georgia; Kortsen, Kristoffer; Pacheco, Ana A. C.; Cavanagh, Robert; Lentz, Joachim C.; Krumins, Eduards; Sanders‐Velez, Carlos; Howdle, Steven M.; Nedoma, Alisyn J.; Taresco, Vincenzo

Authors

Georgia Englezou

Kristoffer Kortsen

Ana A. C. Pacheco

Joachim C. Lentz

Eduards Krumins

Carlos Sanders‐Velez

Alisyn J. Nedoma



Abstract

2‐methyltetrahydrofuran (2‐MeTHF) is a readily available, inexpensive, neoteric, bio‐based solvent. It has been adopted across a wide range of chemical processes including the batch manufacture of fine chemicals, enzymatic polycondensations and ring opening polymerizations. To reduce the environmental burden related to the synthesis of pharmaceutical‐grade polymers based on lactide and caprolactone, we envisaged the use of 2‐MeTHF. For the first time, we combined a series of metal‐free and enzymatic ROPs with free radical and controlled RAFT polymerizations (carried out separately and in tandem) in 2‐MeTHF, in order to easily tune the chemistry and the architecture of the final polymers. After a simple purification, the amphiphilic polymers were formulated into nanoparticles and tested for their cytocompatibility in three model cell lines, to assess their application as potential polymeric excipients for nanomedicines.

Journal Article Type Article
Publication Date Jun 1, 2020
Journal Journal of Polymer Science
Print ISSN 2642-4169
Electronic ISSN 2642-4169
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 58
Issue 11
Pages 1571-1581
APA6 Citation Englezou, G., Kortsen, K., Pacheco, A. A. C., Cavanagh, R., Lentz, J. C., Krumins, E., …Taresco, V. (2020). 2‐Methyltetrahydrofuran (2‐MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations. Journal of Polymer Science, 58(11), 1571-1581. https://doi.org/10.1002/pol.20200183
DOI https://doi.org/10.1002/pol.20200183
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/pol.20200183
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