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Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata (2016)
Journal Article

The continuous flow synthesis of a series of amines was successfully achieved by exploiting the enhanced stability and broad substrate scope of an immobilised transaminases from Halomonas elongata (HEWT). A series of substrates were tested in flow re... Read More about Continuous flow biocatalysis: production and in-line purification of amines by immobilised transaminase from Halomonas elongata.

Understanding the kinetic and thermodynamic origins of xylene separation in UiO-66(Zr) via molecular simulation (2016)
Journal Article

Xylene isomers are precursors in many important chemical processes, yet their separation via crystallization or distillation is energy intensive. Adsorption presents an attractive, lower-energy alternative and the discovery of adsorbents which outper... Read More about Understanding the kinetic and thermodynamic origins of xylene separation in UiO-66(Zr) via molecular simulation.

Direct Measurement of Electron Transfer in Nanoscale Host-Guest Systems: Metallocenes in Carbon Nanotubes (2016)
Journal Article

Electron‐transfer processes play a significant role in host–guest interactions and determine physicochemical phenomena emerging at the nanoscale that can be harnessed in electronic or optical devices, as well as biochemical and catalytic systems. A n... Read More about Direct Measurement of Electron Transfer in Nanoscale Host-Guest Systems: Metallocenes in Carbon Nanotubes.

Catalyst Decomposition during Olefin Metathesis Yields Isomerization-Active Ruthenium Nanoparticles (2016)
Journal Article

The second‐generation Grubbs catalyst, RuCl2(H2IMes)(PCy3) (=CHPh) [GII ; H2IMes=1,3‐bis(2,4,6‐trimethylphenyl)‐4,5‐dihydroimidazol‐2‐ylidene, Cy=cyclohexyl], is shown to decompose during olefin metathesis to generate Ru nanoparticles (RuNPs). These... Read More about Catalyst Decomposition during Olefin Metathesis Yields Isomerization-Active Ruthenium Nanoparticles.

Diversification of ortho-fused cycloocta-2,5-dien-1-one cores and 8 to 6-Ring conversion by sigma bond C-C cleavage (2016)
Journal Article

Sequential treatment of 2-C6H4Br(CHO) with LiC≡CR1 (R1 = SiMe3, tBu), nBuLi, CuBr∙SMe2 and HC≡CCHClR2 [R2 = Ph, 4-CF3Ph, 3-CNPh, 4-(MeO2C)Ph] at -50 oC leads to formation of an intermediate carbanion (Z)-1,2-C6H4{CA(=O)C≡CBR1}{CH=CH(CH–)R2} (4). Low... Read More about Diversification of ortho-fused cycloocta-2,5-dien-1-one cores and 8 to 6-Ring conversion by sigma bond C-C cleavage.

The Interplay Between Conformation and Absolute Configuration in Chiral Electron Dynamics of Small Diols (2016)
Journal Article

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim A competition between chiral characteristics alternatively attributable to either conformation or to absolute configuration is identified. Circular dichroism associated with photoexcitation of the o... Read More about The Interplay Between Conformation and Absolute Configuration in Chiral Electron Dynamics of Small Diols.

Versatile C(sp2)?C(sp3) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes (2016)
Journal Article

The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98?% yield and greater than 99.5?% enantiomeric excess. This ligand coupling reaction is tolerant to multiple substituti... Read More about Versatile C(sp2)?C(sp3) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes.

A feasibility service evaluation of screening and treatment of group A streptococcal pharyngitis in community pharmacies (2016)
Journal Article

Objectives: The UK 5 year antimicrobial resistance strategy recognizes the role of point-of-care diagnostics to identify where antimicrobials are required, as well as to assess the appropriateness of the diagnosis and treatment. A sore throat test-an... Read More about A feasibility service evaluation of screening and treatment of group A streptococcal pharyngitis in community pharmacies.

Versatile C(sp2)−C(sp3) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes (2016)
Journal Article

The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98% yield and greater than 99.5% enantiomeric excess. This ligand coupling reaction is tolerant to multiple substitution... Read More about Versatile C(sp2)−C(sp3) Ligand Couplings of Sulfoxides for the Enantioselective Synthesis of Diarylalkanes.