Outputs (3)

Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring (2009)
Journal Article
Sharkey, D., Gardner, D. S., Symonds, M. E., & Budge, H. (2009). Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring. AJP - Renal Physiology, 297(5), F1199-F1207. https://doi.org/10.1152/ajprenal.00303.2009

Obesity is an independent risk factor for developing chronic kidney disease. Toll-like receptor 4 (TLR4), interleukin (IL)-18, and uncoupling protein 2 (UCP2) are important components of the innate immune system mediating inflammatory renal damage. E... Read More about Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring.

Impact of early onset obesity and hypertension on the unfolded protein response in renal tissues of juvenile sheep (2009)
Journal Article
Sharkey, D., Fainberg, H. P., Wilson, V., Harvey, E., Gardner, D. S., Symonds, M. E., & Budge, H. (2009). Impact of early onset obesity and hypertension on the unfolded protein response in renal tissues of juvenile sheep. Hypertension, 53(6), 925-931. https://doi.org/10.1161/HYPERTENSIONAHA.108.122812

Childhood obesity has reached epidemic proportions. Obesity is an independent risk factor for the development of end-stage renal disease. Endoplasmic reticulum stress and subsequent activation of the unfolded protein response (UPR) are implicated in... Read More about Impact of early onset obesity and hypertension on the unfolded protein response in renal tissues of juvenile sheep.

Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring (2008)
Journal Article
Sharkey, D., Gardner, D. S., Fainberg, H. P., Sébert, S., Bos, P., Wilson, V., Bell, R., Symonds, M. E., & Budge, H. (2009). Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring. FASEB Journal, 23(5), 1314-1324. https://doi.org/10.1096/fj.08-114330

Maternal diet during pregnancy can program an offspring's risk of disease in later life. Obesity adversely alters renal and adipose tissue function, resulting in chronic kidney disease and insulin resistance, respectively, the latter associated with... Read More about Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring.