Outputs (1731)

The optimisation of Pseudotyped viruses for the characterisation of immune responses to equine influenza virus (2016)
Journal Article
Scott, S. D., Kinsley, R., Temperton, N., & Daly, J. M. (2016). The optimisation of Pseudotyped viruses for the characterisation of immune responses to equine influenza virus. Pathogens, 5(4), Article 68. https://doi.org/10.3390/pathogens5040068

Pseudotyped viruses (PVs) produced by co-transfecting cells with plasmids expressing lentiviral core proteins and viral envelope proteins are potentially powerful tools for studying various aspects of equine influenza virus (EIV) biology. The aim of... Read More about The optimisation of Pseudotyped viruses for the characterisation of immune responses to equine influenza virus.

Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS) (2016)
Journal Article
Downes, M. J., Brennan, M. L., Williams, H. C., & Dean, R. S. (2016). Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS). BMJ Open, 6(12), Article e011458. https://doi.org/10.1136/bmjopen-2016-011458

Objectives: The aim of this study was to develop a critical appraisal (CA) tool that addressed study design and reporting quality as well as the risk of bias in cross-sectional studies (CSSs). In addition, the aim was to produce a help document to gu... Read More about Development of a critical appraisal tool to assess the quality of cross-sectional studies (AXIS).

The bio-physics of condensation of divalent cations into the bacterial wall has implications for growth of Gram-positive bacteria (2016)
Journal Article
Rauch, C., Cherkaoui-Rbati, M., Egan, S. A., & Leigh, J. A. (2017). The bio-physics of condensation of divalent cations into the bacterial wall has implications for growth of Gram-positive bacteria. BBA - Biomembranes, 1859(2), https://doi.org/10.1016/j.bbamem.2016.12.002

Background: The anionic-polyelectrolyte nature of the wall of Gram-positive bacteria has long been suspected to be involved in homeostasis of essential cations and bacterial growth. A better understanding of the coupling between the biophysics and th... Read More about The bio-physics of condensation of divalent cations into the bacterial wall has implications for growth of Gram-positive bacteria.

Common decisions made and actions taken during small-animal consultations at eight first-opinion practices in the United Kingdom (2016)
Journal Article
Robinson, N., Brennan, M. L., Cobb, M., & Dean, R. S. (2017). Common decisions made and actions taken during small-animal consultations at eight first-opinion practices in the United Kingdom. Preventive Veterinary Medicine, 139, 1-9. https://doi.org/10.1016/j.prevetmed.2016.12.002

In order for veterinary surgeons to undertake an evidence-based approach to making decisions about theirpatients, it is important that new evidence is generated to support the clinical decision-making process.Many of the decisions are likely to be ar... Read More about Common decisions made and actions taken during small-animal consultations at eight first-opinion practices in the United Kingdom.

Searching the veterinary literature: a comparison of the coverage of veterinary journals by nine bibliographic databases (2016)
Journal Article
Grindlay, D. J., Brennan, M. L., & Dean, R. S. (in press). Searching the veterinary literature: a comparison of the coverage of veterinary journals by nine bibliographic databases. Journal of Veterinary Medical Education, 39(4), https://doi.org/10.3138/jvme.1111.109R

A thorough search of the literature to find the best evidence is central to the practice of evidence-based veterinary medicine. This requires knowing which databases to search to maximize journal coverage. The aim of the present study was to compare... Read More about Searching the veterinary literature: a comparison of the coverage of veterinary journals by nine bibliographic databases.

Detection of transmissible viral proventriculitis (TVP) and Chicken proventricular necrosis virus (CPNV) in the United Kingdom (2016)
Journal Article
Grau-Roma, L., Reid, K., de Brot, S., Jennison, R., Barrow, P., Sánchez, R., Nofrarías, M., Clark, M., & Majó, N. (2017). Detection of transmissible viral proventriculitis (TVP) and Chicken proventricular necrosis virus (CPNV) in the United Kingdom. Avian Pathology, 46(1), 68-75. https://doi.org/10.1080/03079457.2016.1207751

Increasing evidence suggests that a new birnavirus, named Chicken proventricular necrosis virus (CPNV), is the aetiological agent of transmissible viral proventriculitis (TVP). The present work aimed to explore the possible presence of both TVP and C... Read More about Detection of transmissible viral proventriculitis (TVP) and Chicken proventricular necrosis virus (CPNV) in the United Kingdom.

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination (2016)
Journal Article
Haussmann, I. U., Bodi, Z., Sanchez-Moran, E., Mongan, N. P., Archer, N., Fray, R. G., & Soller, M. (2016). m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature, 540(7632), 301-304. https://doi.org/10.1038/nature20577

N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7. The mammalian mRNA m6A methylosome is a complex of nuclear proteins that includes METTL3 (m... Read More about m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination.

DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis (2016)
Journal Article
Glossop, J. R., Nixon, N. B., Emes, R. D., Sim, J., Packman, J. C., Mattey, D. L., Farrell, W. E., & Fryer, A. A. (2016). DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis. Epigenomics, 9(4), https://doi.org/10.2217/epi-2016-0042

Aim: A proof-of-concept study to explore whether DNA methylation at first diagnosis is associated with response to disease-modifying antirheumatic drugs (DMARDs) in patients with early rheumatoid arthritis (RA). Patients & methods: DNA methylation wa... Read More about DNA methylation at diagnosis is associated with response to disease-modifying drugs in early rheumatoid arthritis.

Accuracy of the electronic patient record in a first opinion veterinary practice (2016)
Journal Article
Jones-Diette, J., Robinson, N., Cobb, M., Brennan, M. L., & Dean, R. S. (2017). Accuracy of the electronic patient record in a first opinion veterinary practice. Preventive Veterinary Medicine, 148, https://doi.org/10.1016/j.prevetmed.2016.11.014

The use of electronic patient records (EPRs) in veterinary research is becoming more common place. To date no-one has investigated how accurately and completely they represent the clinical interactions that happen between veterinary professionals, an... Read More about Accuracy of the electronic patient record in a first opinion veterinary practice.

Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records (2016)
Journal Article
Welsh, C. E., Duz, M., Parkin, T. D., & Marshall, J. F. (2017). Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records. Preventive Veterinary Medicine, 136, https://doi.org/10.1016/j.prevetmed.2016.11.012

Electronic medical records from first opinion equine veterinary practice may represent a unique resource for epidemiologic research. The appropriateness of this resource for risk factor analyses was explored as part of an investigation into clinical... Read More about Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records.