Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records

Welsh, Claire E.; Duz, Marco; Parkin, Timothy D.H.; Marshall, John F.

Abstract

Electronic medical records from first opinion equine veterinary practice may represent a unique resource for epidemiologic research. The appropriateness of this resource for risk factor analyses was explored as part of an investigation into clinical and pharmacologic risk factors for laminitis. Amalgamated medical records from seven UK practices were subjected to text mining to identify laminitis episodes, systemic or intra-synovial corticosteroid prescription, diseases known to affect laminitis risk and clinical signs or syndromes likely to lead to corticosteroid use. Cox proportional hazard models and Prentice, Williams, Peterson models for repeated events were used to estimate associations with time to first, or subsequent laminitis episodes, respectively. Over seventy percent of horses that were diagnosed with laminitis suf- fered at least one recurrence. Risk factors for first and subsequent laminitis episodes were found to vary. Corticosteroid use (prednisolone only) was only significantly associated with subsequent, and not ini- tial laminitis episodes. Electronic medical record use for such analyses is plausible and offers important advantages over more traditional data sources. It does, however, pose challenges and limitations that must be taken into account, and requires a conceptual change to disease diagnosis which should be considered carefully.

Citation

Welsh, C. E., Duz, M., Parkin, T. D., & Marshall, J. F. (2017). Disease and pharmacologic risk factors for first and subsequent episodes of equine laminitis: a cohort study of free-text electronic medical records. Preventive Veterinary Medicine, 136, https://doi.org/10.1016/j.prevetmed.2016.11.012

• Journal Article Type: Article
• Acceptance Date: Nov 21, 2016
• Online Publication Date: Nov 22, 2016
• Publication Date: Jan 1, 2017
• Deposit Date: Feb 3, 2017
• Publicly Available Date: Feb 3, 2017
• Journal: Preventive Veterinary Medicine
• Print ISSN: 0167-5877
• Electronic ISSN: 1873-1716
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 136
• DOI: https://doi.org/10.1016/j.prevetmed.2016.11.012
• Keywords: laminitis, horse, electronic medical records, text mining
• Public URL: https://nottingham-repository.worktribe.com/output/830966
• Publisher URL: http://www.sciencedirect.com/science/article/pii/S0167587716305815
• Contract Date: Feb 3, 2017