Outputs (105)

DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS (2015)
Journal Article
Glossop, J. R., Haworth, K. E., Emes, R. D., Nixon, N. B., Packham, J. C., Dawes, P. T., …Farrell, W. E. (2015). DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS. Epigenomics, 7(4), https://doi.org/10.2217/epi.15.15

Aims: Alterations in DNA methylation contribute to the abnormal phenotype of fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA). Herein, we performed genome-wide DNA methylation profiling of RA FLS derived from synovial f... Read More about DNA methylation profiling of synovial fluid FLS in rheumatoid arthritis reveals changes common with tissue-derived FLS.

Regulation of vascular endothelial growth factor in prostate cancer (2015)
Journal Article
de Brot, S., Ntekim, A., Cardenas, R., James, V., Allegrucci, C., Heery, D. M., …Mongan, N. P. (2015). Regulation of vascular endothelial growth factor in prostate cancer. Endocrine-Related Cancer, 22(3), Article R107-R123. https://doi.org/10.1530/ERC-15-0123

Prostate cancer (PCa) is the most common malignancy affecting men in the western world. Although radical prostatectomy and radiation therapy can successfully treat PCa in the majority of patients, up to ∼30% will experience local recurrence or metast... Read More about Regulation of vascular endothelial growth factor in prostate cancer.

Cattle veterinarians' awareness and understanding of biosecurity (2015)
Journal Article
Pritchard, K., Wapenaar, W., & Brennan, M. L. (2015). Cattle veterinarians' awareness and understanding of biosecurity. Veterinary Record, 176(21), Article 546. https://doi.org/10.1136/vr.102899

PREVENTIVE biosecurity measures, such as isolation of purchased animals, are well documented in the literature (Duncan 1990, Maunsell and Donovan 2008, Noremark and others 2009) and biosecurity has been highlighted as a key intervention for many of t... Read More about Cattle veterinarians' awareness and understanding of biosecurity.

Semen quality, testicular B-mode and Doppler ultrasound, and serum testosterone concentrations in dogs with established infertility (2015)
Journal Article
de Souza, M. B., England, G. C., Mota Filho, A. C., Ackermann, C. L., Sousa, C. V. S., de Carvalho, G. G., …da Silva, L. D. M. (in press). Semen quality, testicular B-mode and Doppler ultrasound, and serum testosterone concentrations in dogs with established infertility. Theriogenology, 84(5), https://doi.org/10.1016/j.theriogenology.2015.05.015

Retrospective examination of breeding records enabled the identification of 10 dogs of normal fertility and 10 dogs with established infertility of at least 12 months of duration. Comparisons of testicular palpation, semen evaluation, testicular ultr... Read More about Semen quality, testicular B-mode and Doppler ultrasound, and serum testosterone concentrations in dogs with established infertility.

Opening up animal research and science-society relations?: a thematic analysis of transparency discourses in the United Kingdom (2015)
Journal Article
McLeod, C., & Hobson-West, P. (2016). Opening up animal research and science-society relations?: a thematic analysis of transparency discourses in the United Kingdom. Public Understanding of Science, 25(7), https://doi.org/10.1177/0963662515586320

The use of animals in scientific research represents an interesting case to consider in the context of the contemporary preoccupation with transparency and openness in science and governance. In the United Kingdom, organisations critical of animal re... Read More about Opening up animal research and science-society relations?: a thematic analysis of transparency discourses in the United Kingdom.

Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation (2015)
Journal Article
Orfali, N., O'Donovan, T. R., Nyhan, M. J., Britschgi, A., Tschan, M. P., Cahill, M. R., …McKenna, S. L. (2015). Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation. Experimental Hematology, 43(9), 781-793.e2. https://doi.org/10.1016/j.exphem.2015.04.012

Acute myeloid leukemia (AML) is characterized by the accumulation of immature blood cell precursors in the bone marrow. Pharmacologically overcoming the differentiation block in this condition is an attractive therapeutic avenue, which has achieved s... Read More about Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation.

Evaluation of treatments for claw horn lesions in dairy cows in a randomized controlled trial (2015)
Journal Article
Thomas, H., Miguel-Pacheco, G., Bollard, N., Archer, S., Bell, N., Mason, C., …Huxley, J. (2015). Evaluation of treatments for claw horn lesions in dairy cows in a randomized controlled trial. Journal of Dairy Science, 98(7), 4477-4486. https://doi.org/10.3168/jds.2014-8982

Lameness is one of the most significant endemic disease problems facing the dairy industry. Claw horn lesions (principally sole hemorrhage, sole ulcer, and white line disease) are some of the most prevalent conditions. Despite the fact that thousands... Read More about Evaluation of treatments for claw horn lesions in dairy cows in a randomized controlled trial.

Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease (2015)
Journal Article
Inns, J., & James, V. (2015). Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease. Breast, 24(4), 364-369. https://doi.org/10.1016/j.breast.2015.04.001

Breast cancer is the second most common malignancy diagnosed in women worldwide. The greatest cause of breast cancer mortality is development of metastasis. For many women metastasis is an early event in breast cancer which goes undetected until its... Read More about Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease.

Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time (2015)
Journal Article
Maddison, B. C., Spiropoulos, J., Vickery, C. M., Lockey, R., Owen, J. P., Bishop, K., …Gough, K. C. (2015). Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time. Veterinary Research, 46, Article 46. https://doi.org/10.1186/s13567-015-0179-y

Ovine scrapie can be transmitted via environmental reservoirs. A pool of ovine scrapie isolates were incubated on soil for one day or thirteen months and eluted prion was used to challenge tg338 mice transgenic for ovine PrP. After one-day incubation... Read More about Incubation of ovine scrapie with environmental matrix results in biological and biochemical changes of PrPSc over time.

Sensitive recovery of recombinant antibody clones after their in silico identification within NGS datasets (2015)
Journal Article
Spiliotopoulos, A., Owen, J. P., Maddison, B. C., Dreveny, I., Rees, H. C., & Gough, K. C. (2015). Sensitive recovery of recombinant antibody clones after their in silico identification within NGS datasets. Journal of Immunological Methods, 420, https://doi.org/10.1016/j.jim.2015.03.005

Recently the analytical power of the latest high throughput next generation DNA sequencing platforms has been used to analyse phage that have been selected from the panning of large combinatorial libraries displaying either peptide or antibody ligand... Read More about Sensitive recovery of recombinant antibody clones after their in silico identification within NGS datasets.