Outputs (1359)

Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients (2024)
Journal Article
Tarlinton, R., Tanasescu, R., Shannon-Lowe, C., & Gran, B. (2024). Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients. Multiple Sclerosis and Related Disorders, 86, Article 105597. https://doi.org/10.1016/j.msard.2024.105597

Background Epstein barr virus (EBV) infection of B cells is now understood to be one of the triggering events for the development of Multiple Sclerosis (MS), a progressive immune-mediated disease of the central nervous system. EBV infection is also... Read More about Ocrelizumab B cell depletion has no effect on HERV RNA expression in PBMC in MS patients.

Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species (2024)
Journal Article
Bhandare, S., Lawal, O. U., Colavecchio, A., Cadieux, B., Zahirovich-Jovich, Y., Zhong, Z., …Goodridge, L. (2024). Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species. Microorganisms, 12(4), Article 695. https://doi.org/10.3390/microorganisms12040695

Bacteriophages (phages) are potential alternatives to chemical antimicrobials against pathogens of public health significance. Understanding the diversity and host specificity of phages is important for developing effective phage biocontrol approache... Read More about Genomic and Phenotypic Analysis of Salmonella enterica Bacteriophages Identifies Two Novel Phage Species.

SnoRNAs in cardiovascular development, function, and disease (2024)
Journal Article
Chabronova, A., Holmes, T. L., Hoang, D. M., Denning, C., James, V., Smith, J. G. W., & Peffers, M. J. (2024). SnoRNAs in cardiovascular development, function, and disease. Trends in Molecular Medicine, 30(6), 562-578. https://doi.org/10.1016/j.molmed.2024.03.004

Small nucleolar RNAs (snoRNAs) are emerging as important regulators of cardiovascular (patho)biology. Several roles of snoRNAs have recently been identified in heart development and congenital heart diseases, as well as their dynamic regulation in hy... Read More about SnoRNAs in cardiovascular development, function, and disease.

A core genome multi-locus sequence typing scheme for Streptococcus uberis: an evolution in typing a genetically diverse pathogen (2024)
Journal Article
Whiley, D., Jolley, K., Blanchard, A., Coffey, T., & Leigh, J. (2024). A core genome multi-locus sequence typing scheme for Streptococcus uberis: an evolution in typing a genetically diverse pathogen. Microbial Genomics, 10(3), https://doi.org/10.1099/mgen.0.001225

Streptococcus uberis is a globally endemic and poorly controlled cause of bovine mastitis impacting the sustainability of the modern dairy industry. A core genome was derived from 579 newly sequenced S. uberis isolates, along with 305 publicly availa... Read More about A core genome multi-locus sequence typing scheme for Streptococcus uberis: an evolution in typing a genetically diverse pathogen.

Global prevalence and risk factors associated with Toxoplasma gondii infection in wild birds: A systematic review and meta-analysis (2024)
Journal Article
Chen, C., Qin, S.-Y., Yang, X., Li, X.-M., Cai, Y., Lei, C.-C., …Cao, H. (2024). Global prevalence and risk factors associated with Toxoplasma gondii infection in wild birds: A systematic review and meta-analysis. Preventive Veterinary Medicine, 226, Article 106187. https://doi.org/10.1016/j.prevetmed.2024.106187

A systematic review and meta-analysis were performed to identify the global prevalence and factors associated with Toxoplasma gondii infection in wild birds. Six bibliographic databases (Chinese National Knowledge Infrastructure, VIP Chinese Journal... Read More about Global prevalence and risk factors associated with Toxoplasma gondii infection in wild birds: A systematic review and meta-analysis.

Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines (2024)
Journal Article
Sørensen, T. M., Scahill, K., Ruperez, J. E., Olejnik, M., Swinbourne, F., Verwilghen, D. R., …Allerton, F. (2024). Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines. Veterinary Journal, 304, Article 106101. https://doi.org/10.1016/j.tvjl.2024.106101

Surgical antimicrobial prophylaxis (SAP) is widely used to reduce the risk of surgical site infections (SSI), but there is uncertainty as to what the proportion of SSI reduction is. Therefore, it is difficult for surgeons to properly weigh the costs,... Read More about Antimicrobial prophylaxis in companion animal surgery: A scoping review for European Network for Optimization of Antimicrobial Therapy (ENOVAT) guidelines.

Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle (2024)
Journal Article
Wang, S.-S., Wang, X., He, J.-J., Zheng, W.-B., Zhu, X.-Q., Elsheikha, H. M., & Zhou, C.-X. (2024). Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle. Parasitology Research, 123(2), Article 145. https://doi.org/10.1007/s00436-024-08152-x

Toxoplasma gondii is an opportunistic protozoan parasite that is highly prevalent in the human population and can lead to adverse health consequences in immunocompromised patients and pregnant women. Noncoding RNAs, such as microRNAs (miRNAs) and cir... Read More about Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle.

Dolphin-WET—Development of a Welfare Evaluation Tool for Bottlenose Dolphins (Tursiops truncatus) under Human Care (2024)
Journal Article
Baumgartner, K., Hüttner, T., Clegg, I. L. K., Garcia Hartmann, M., Garcia-Párraga, D., Manteca, X., …Delfour, F. (2024). Dolphin-WET—Development of a Welfare Evaluation Tool for Bottlenose Dolphins (Tursiops truncatus) under Human Care. Animals, 14(5), Article 701. https://doi.org/10.3390/ani14050701

Ensuring high standards of animal welfare is not only an ethical duty for zoos and aquariums, but it is also essential to achieve their conservation, education, and research goals. While for some species, animal welfare assessment frameworks are alre... Read More about Dolphin-WET—Development of a Welfare Evaluation Tool for Bottlenose Dolphins (Tursiops truncatus) under Human Care.

An in silico and in vitro assessment of the neurotoxicity of mefloquine (2024)
Journal Article
El Sharazly, B. M., Ahmed, A., Elsheikha, H. M., & Carter, W. G. (2024). An in silico and in vitro assessment of the neurotoxicity of mefloquine. Biomedicines, 12(3), Article 505. https://doi.org/10.3390/biomedicines12030505

Mefloquine (MQ) is a quinoline-based anti-malarial drug used for chemoprophylaxis or as treatment in combination with artesunate. Although MQ has clear anti-Plasmodium properties, it can induce neurotoxicity and undesired neuropsychiatric side effect... Read More about An in silico and in vitro assessment of the neurotoxicity of mefloquine.

Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles (2024)
Journal Article
Brown, T. J., Rutland, C. S., Rutland, C. S., Choi, K. K., Tse, F., Pfeffers, M. J., …James, V. (2024). Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles. Frontiers in Cell and Developmental Biology, 12, Article 1354606. https://doi.org/10.3389/fcell.2024.1354606

Prostate cancer (PCa) is a leading male malignancy worldwide, often progressing to bone metastasis, with limited curative options. Extracellular vesicles (EVs) have emerged as key players in cancer communication and metastasis, promoting the formatio... Read More about Modulation of the pre-metastatic bone niche: molecular changes mediated by bone-homing prostate cancer extracellular vesicles.