Outputs (11)

The long and short of it: benchmarking viromics using Illumina, Nanopore and PacBio sequencing technologies (2024)
Journal Article
Cook, R., Brown, N., Rihtman, B., Michniewski, S., Redgwell, T., Clokie, M., …Millard, A. (2024). The long and short of it: benchmarking viromics using Illumina, Nanopore and PacBio sequencing technologies. Microbial Genomics, 10(2), Article 0.001198. https://doi.org/10.1099/mgen.0.001198

Viral metagenomics has fuelled a rapid change in our understanding of global viral diversity and ecology. Long-read sequencing and hybrid assembly approaches that combine long- and short-read technologies are now being widely implemented in bacterial... Read More about The long and short of it: benchmarking viromics using Illumina, Nanopore and PacBio sequencing technologies.

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens (2021)
Journal Article
Cook, R., Hooton, S., Trivedi, U., King, L., Dodd, C. E., Hobman, J. L., …Millard, A. D. (2021). Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens. Microbiome, 9, Article 65. https://doi.org/10.1186/s40168-021-01010-3

Viruses are the most abundant biological entities on Earth, known to be crucial components of microbial ecosystems. However, there is little information on the viral community within agricultural waste. There are currently ~ 2.7 million dairy cattle... Read More about Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens.

A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response (2018)
Journal Article
Tang, Y., Foster, N., Jones, M. A., & Barrow, P. A. (2018). A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response. Infection and Immunity, 86(8), Article e00307-18. https://doi.org/10.1128/IAI.00307-18

Salmonella enterica infection affects a wide range of animals and human and a small number of serovars cause typhoid-like infections, one characteristic of which is persistent infection in convalescents. The avian specific serovar S Pullorum produces... Read More about A model of persistent Salmonella infection: Salmonella pullorum modulates the immune response of the chicken from a Th17 towards a Th2-type response.

Novel inflammatory cell infiltration scoring system to investigate healthy and footrot affected ovine interdigital skin (2018)
Journal Article
Agbaje, M., Rutland, C. S., Maboni, G., Blanchard, A., Bexon, M., Stewart, C., Jones, M. A., & Totemeyer, S. (2018). Novel inflammatory cell infiltration scoring system to investigate healthy and footrot affected ovine interdigital skin. PeerJ, 6, Article e5097. https://doi.org/10.7717/peerj.5097

Ovine footrot is a degenerative disease of sheep feet leading to the separation of hoofhorn from the underlying skin and lameness. This study quantitatively examined histological features of the ovine interdigital skin as well as their relationship w... Read More about Novel inflammatory cell infiltration scoring system to investigate healthy and footrot affected ovine interdigital skin.

Erratum for Aidley et al., “Nonselective Bottlenecks Control the Divergence and Diversification of Phase-Variable Bacterial Populations” (2017)
Journal Article
Aidley, J., Jones, M. A., Rajopadhye, S., Akinyemi, N. M., Lango-Scholey, L., & Bayliss, C. D. (2017). Erratum for Aidley et al., “Nonselective Bottlenecks Control the Divergence and Diversification of Phase-Variable Bacterial Populations”. mBio, 8(4), Article e00878-17. https://doi.org/10.1128/mBio.00878-17

© 2017 Aidley et al. Volume 8, no. 2, e02311-16, 2017, https://doi.org/10.1128/mBio.02311-16. The byline and affiliation line of our article should appear as shown above. The following should also be added to the end of Acknowledgments: “M.A.J. was s... Read More about Erratum for Aidley et al., “Nonselective Bottlenecks Control the Divergence and Diversification of Phase-Variable Bacterial Populations”.

Nonselective Bottlenecks Control the Divergence and Diversification of Phase-Variable Bacterial Populations (2017)
Journal Article
Aidley, J. B., Rajopadhye, S., Akinyemi, N., Lango-Scholey, L., Jones, M. A., & Bayliss, C. D. (2017). Nonselective Bottlenecks Control the Divergence and Diversification of Phase-Variable Bacterial Populations. mBio, 8(2), 1-14. https://doi.org/10.1128/mBio.02311-16

Phase variation occurs in many pathogenic and commensal bacteria and is a major generator of genetic variability. A putative advantage of phase variation is to counter reductions in variability imposed by nonselective bottlenecks during transmission.... Read More about Nonselective Bottlenecks Control the Divergence and Diversification of Phase-Variable Bacterial Populations.

High throughput method for analysis of repeat number for 28 phase variable loci of C. jejuni strain NCTC11168 (2016)
Journal Article
Lango-Scholey, L., Aidley, J., Woodacre, A., Jones, M. A., & Bayliss, C. D. (2016). High throughput method for analysis of repeat number for 28 phase variable loci of C. jejuni strain NCTC11168. PLoS ONE, 11(7), 1-15. https://doi.org/10.1371/journal.pone.0159634

Mutations in simple sequence repeat tracts are a major mechanism of phase variation in several bacterial species including Campylobacter jejuni. Changes in repeat number of tracts located within the reading frame can produce a high frequency of rever... Read More about High throughput method for analysis of repeat number for 28 phase variable loci of C. jejuni strain NCTC11168.

The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens (2016)
Journal Article
Psifidi, A., Fife, M., Howell, J., Matika, O., van Diemen, P., Kuo, R., …Kaiser, P. (2016). The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens. BMC Genomics, 17(1), Article 293. https://doi.org/10.1186/s12864-016-2612-7

Campylobacter is the leading cause of foodborne diarrhoeal illness in humans and is mostly acquired from consumption or handling of contaminated poultry meat. In the absence of effective licensed vaccines and inhibitors, selection for chickens with i... Read More about The genomic architecture of resistance to Campylobacter jejuni intestinal colonisation in chickens.

Campylobacter jejuni PflB is required for motility and colonisation of the chicken gastrointestinal tract (2015)
Journal Article
Kanji, A., Jones, M., Maskell, D. J., & Grant, A. J. (2015). Campylobacter jejuni PflB is required for motility and colonisation of the chicken gastrointestinal tract. Microbial Pathogenesis, 89, https://doi.org/10.1016/j.micpath.2015.09.010

Campylobacter jejuni is the leading cause of foodborne bacterial gastroenteritis worldwide. Although the mechanisms by which C. jejuni causes disease are not completely understood, the presence of functional flagella appears to be required for coloni... Read More about Campylobacter jejuni PflB is required for motility and colonisation of the chicken gastrointestinal tract.

Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation (2014)
Journal Article
Karlyshev, A., Thacker, G., Jones, M., Clements, M., & Wren, B. W. (2014). Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation. FEBS Open Bio, 4(1), https://doi.org/10.1016/j.fob.2014.04.012

According to MEROPS peptidase database, Campylobacter species encode 64 predicted peptidases. However, proteolytic properties of only a few of these proteins have been confirmed experimentally. In this study we identified and characterised a Campylob... Read More about Campylobacter jejuni gene cj0511 encodes a serine peptidase essential for colonisation.