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Outputs (91)

Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus) (2023)
Journal Article
Abd-Elhafeez, H. H., Rutland, C. S., & Soliman, S. A. (2023). Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus). Microscopy Research and Technique, 86(9), 1108-1121. https://doi.org/10.1002/jemt.24374

Telocytes (TCs) are present in a broad range of species and regulate processes including homeostasis, tissue regeneration and immunosurveillance. This novel study describes the morphological features of migrating TCs and their role during cartilage d... Read More about Morphology of migrating telocytes and their potential role in stem cell differentiation during cartilage development in catfish (Clarias gariepinus).

Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? (2023)
Journal Article
Ghannam, S. F., Rutland, C. S., Allegrucci, C., Mongan, N. P., & Rakha, E. (2023). Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?. Histopathology, 83(3), 376-393. https://doi.org/10.1111/his.14939

Background Encapsulated papillary carcinoma (EPC) is surrounded by a thick fibrous capsule-like structure, which is interpreted as a thickened basement membrane (BM). This study aimed to describe the geometric characteristics of the EPC capsule and... Read More about Encapsulated papillary carcinoma of the breast: does it have a native basement membrane?.

Topographic anatomy and vascularization of the glandula thyroidea in rats (2023)
Journal Article
Nur, I. H., Pérez, W., & Rutland, C. S. (2023). Topographic anatomy and vascularization of the glandula thyroidea in rats. Anatomia, Histologia, Embryologia, 52(4), 571-582. https://doi.org/10.1111/ahe.12916

Topographical anatomy and detailed measurements of the glandula thyroidea (thyroid gland) and the glandula parathyroidea (parathyroid gland) were determined in rats, with significant differences identified between the sexes. In the rats (N=10 male, 1... Read More about Topographic anatomy and vascularization of the glandula thyroidea in rats.

Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports (2023)
Preprint / Working Paper
Kovac, M., Aliev, R., Berestov, I., Aimaletdinov, A., Rutland, C., Rizvanov, A., & Zakirova, E. Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports

Injury to the proximal part of the equine suspensory ligament (SL), called proximal suspensory desmitis (PSD), commonly causes lameness in horses. PSD is extremely difficult to manage and treat, with present methods often unable to achieve full recov... Read More about Gene Therapy Using Plasmid DNA Encoding Bone Morphogenetic Protein 2 and Vascular Endothelial Growth Factor 164 Genes for the Treatment of Equine Proximal Suspensory Desmitis: Case Reports.

The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode (2023)
Journal Article
Baron, F., Zhang, M., Archer, N., Bellows, E., Knight, H. M., Welham, S., …Bodi, Z. (2023). The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode. RNA, 29(6), 777-789. https://doi.org/10.1261/rna.079615.123

N6-methyladenosine (m6A) in mRNA regulates almost every stage in the mRNA life cycle, and the development of methodologies for the high-throughput detection of methylated sites in mRNA using m6A-specific methylated RNA immunoprecipitation with next-g... Read More about The importance of m6A topology in chicken embryo mRNA: a precise mapping of m6A at the conserved chicken β-actin zipcode.

Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells (2023)
Journal Article
Soliman, S. A., Abd-Elhafeez, H. H., Mohamed, N., Al-Rashdi, B. M., Alghamdi, A. A., Elmansi, A., …Massoud, D. (2023). Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells. Microscopy Research and Technique, 86(5), 600-613. https://doi.org/10.1002/jemt.24298

Varanus niloticus is a lizard residing within the Varanidae family. To date no studies detailing its blood morphology and characteristics have been conducted. This study used histologically stained blood and bone marrow samples to visualize the cells... Read More about Morphological and cytochemical characteristics of Varanus niloticus (Squamata, Varanidae) blood cells.

Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer (2023)
Journal Article
Lothion-Roy, J., Haigh, D. B., Harris, A. E., Metzler, V. M., Alsaleem, M., Toss, M. S., …Woodcock, C. L. (2023). Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Frontiers in Genetics, 13, Article 1096071. https://doi.org/10.3389/fgene.2022.1096071

N6-methyladenosine (m6A) is the most abundant internal mRNA modification and is dynamically regulated through distinct protein complexes that methylate, demethylate, and/or interpret the m6A modification. These proteins, and the m6A modification, are... Read More about Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer.

The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer (2023)
Journal Article
Metzler, V. M., de Brot, S., Haigh, D. B., Woodcock, C. L., Lothion-Roy, J., Harris, A. E., …Jeyapalan, J. N. (2023). The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Frontiers in Cell and Developmental Biology, 11, Article 1116424. https://doi.org/10.3389/fcell.2023.1116424

Histone H3 lysine 4 (H3K4) methylation is key epigenetic mark associated with active transcription and is a substrate for the KDM1A/LSD1 and KDM5B/JARID1B lysine demethylases. Increased expression of KDM1A and KDM5B is implicated in many cancer types... Read More about The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer.

Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery (2022)
Journal Article
Simpson, S., Rizvanov, A. A., Jeyapalan, J. N., de Brot, S., & Rutland, C. S. (2022). Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. Frontiers in Veterinary Science, 9, Article 965391. https://doi.org/10.3389/fvets.2022.965391

Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs tha... Read More about Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery.