Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery

Simpson, Siobhan; Rizvanov, Albert A.; Jeyapalan, Jennie N.; de Brot, Simone; Rutland, Catrin S.

doi:10.3389/fvets.2022.965391

Authors

Siobhan Simpson

Albert A. Rizvanov

Dr JENNIE JEYAPALAN plzjnj@exmail.nottingham.ac.uk
Assistant Professor

Simone de Brot

CATRIN RUTLAND catrin.rutland@nottingham.ac.uk
Associate Professor

Abstract

Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs than people. Dogs therefore not only require treatment themselves but can also act as an effective parallel patient population for the human disease equivalent. It should be noted that although there are many similarities between canine and human OSA, there are also key differences and it is important to research and highlight these features. Despite progress using chorioallantoic membrane models, 2D and 3D in vitro models, and rodent OSA models, many more insights into the molecular and cellular mechanisms, drug development, and treatment are being discovered in a variety of canine OSA patient populations.

Citation

Simpson, S., Rizvanov, A. A., Jeyapalan, J. N., de Brot, S., & Rutland, C. S. (2022). Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. Frontiers in Veterinary Science, 9, Article 965391. https://doi.org/10.3389/fvets.2022.965391

Journal Article Type	Article
Acceptance Date	Nov 23, 2022
Online Publication Date	Dec 8, 2022
Publication Date	Dec 8, 2022
Deposit Date	Mar 13, 2023
Publicly Available Date	Mar 14, 2023
Journal	Frontiers in Veterinary Science
Print ISSN	2297-1769
Electronic ISSN	2297-1769
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	9
Article Number	965391
DOI	https://doi.org/10.3389/fvets.2022.965391
Keywords	Veterinary Science, bone cancer, canine, genes, human, osteosarcoma, protein, treatment
Public URL	https://nottingham-repository.worktribe.com/output/15432425
Publisher URL	https://www.frontiersin.org/articles/10.3389/fvets.2022.965391/full