Siobhan Simpson
Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery
Simpson, Siobhan; Rizvanov, Albert A.; Jeyapalan, Jennie N.; de Brot, Simone; Rutland, Catrin S.
Authors
Albert A. Rizvanov
Dr JENNIE JEYAPALAN plzjnj@exmail.nottingham.ac.uk
Assistant Professor
Simone de Brot
CATRIN RUTLAND catrin.rutland@nottingham.ac.uk
Associate Professor
Abstract
Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs than people. Dogs therefore not only require treatment themselves but can also act as an effective parallel patient population for the human disease equivalent. It should be noted that although there are many similarities between canine and human OSA, there are also key differences and it is important to research and highlight these features. Despite progress using chorioallantoic membrane models, 2D and 3D in vitro models, and rodent OSA models, many more insights into the molecular and cellular mechanisms, drug development, and treatment are being discovered in a variety of canine OSA patient populations.
Citation
Simpson, S., Rizvanov, A. A., Jeyapalan, J. N., de Brot, S., & Rutland, C. S. (2022). Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. Frontiers in Veterinary Science, 9, Article 965391. https://doi.org/10.3389/fvets.2022.965391
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 23, 2022 |
Online Publication Date | Dec 8, 2022 |
Publication Date | Dec 8, 2022 |
Deposit Date | Mar 13, 2023 |
Publicly Available Date | Mar 14, 2023 |
Journal | Frontiers in Veterinary Science |
Print ISSN | 2297-1769 |
Electronic ISSN | 2297-1769 |
Publisher | Frontiers Media |
Peer Reviewed | Peer Reviewed |
Volume | 9 |
Article Number | 965391 |
DOI | https://doi.org/10.3389/fvets.2022.965391 |
Keywords | Veterinary Science, bone cancer, canine, genes, human, osteosarcoma, protein, treatment |
Public URL | https://nottingham-repository.worktribe.com/output/15432425 |
Publisher URL | https://www.frontiersin.org/articles/10.3389/fvets.2022.965391/full |
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Publisher Licence URL
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