Skip to main content

Research Repository

Advanced Search

Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery

Simpson, Siobhan; Rizvanov, Albert A.; Jeyapalan, Jennie N.; de Brot, Simone; Rutland, Catrin S.


Siobhan Simpson

Albert A. Rizvanov

Simone de Brot


Cancer is a leading cause of non-communicable morbidity and mortality throughout the world, similarly, in dogs, the most frequent cause of mortality is tumors. Some types of cancer, including osteosarcoma (OSA), occur at much higher rates in dogs than people. Dogs therefore not only require treatment themselves but can also act as an effective parallel patient population for the human disease equivalent. It should be noted that although there are many similarities between canine and human OSA, there are also key differences and it is important to research and highlight these features. Despite progress using chorioallantoic membrane models, 2D and 3D in vitro models, and rodent OSA models, many more insights into the molecular and cellular mechanisms, drug development, and treatment are being discovered in a variety of canine OSA patient populations.


Simpson, S., Rizvanov, A. A., Jeyapalan, J. N., de Brot, S., & Rutland, C. S. (2022). Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. Frontiers in Veterinary Science, 9, Article 965391.

Journal Article Type Article
Acceptance Date Nov 23, 2022
Online Publication Date Dec 8, 2022
Publication Date Dec 8, 2022
Deposit Date Mar 13, 2023
Publicly Available Date Mar 14, 2023
Journal Frontiers in Veterinary Science
Print ISSN 2297-1769
Electronic ISSN 2297-1769
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 9
Article Number 965391
Keywords Veterinary Science, bone cancer, canine, genes, human, osteosarcoma, protein, treatment
Public URL
Publisher URL


You might also like

Downloadable Citations