Outputs (571)

Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders? (2019)
Journal Article
Corsetti, M., Pannemans, J., & Whorwell, P. (2019). Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research, 8, Article 257. https://doi.org/10.12688/f1000research.15974.1

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term bas... Read More about Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?.

Spatio-Temporal Motility MRI analysis of the stomach and colon (2019)
Journal Article
Menys, A., Hoad, C., Spiller, R., Scott, M., Atkinson, D., Marciani, L., & Taylor, S. (2019). Spatio-Temporal Motility MRI analysis of the stomach and colon. Neurogastroenterology and Motility, 31(5), Article e13557. https://doi.org/10.1111/nmo.13557

Background: MRI is increasingly used to objectively assess gastrointestinal motility. However, motility metrics often do no not offer insights into the nature of contractile action. This study introduces a systematic method of making spatiotemporal m... Read More about Spatio-Temporal Motility MRI analysis of the stomach and colon.

Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28 (2019)
Journal Article
Levy, N., Lobo, D. N., Fawcett, W. J., Ljungqvist, O., & Scott, M. J. (2019). Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28. British Journal of Anaesthesia, 22(6), e215–e216. https://doi.org/10.1016/j.bja.2019.01.028

We read with interest the special and insightful article by Soffin and colleagues1 on the prescription opioid crisis. They carefully examine many of the drivers for subsequent opioid dependence after surgery and provide suggestions on how practice ca... Read More about Opioid stewardship: a need for opioid discharge guidance: comment on Br J Anaesth 2018 Dec 28.

The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis (2019)
Journal Article
Adiamah, A., Skořepa, P., Weimann, A., & Lobo, D. N. (2019). The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis. Annals of Surgery, 270(2), 247-246. https://doi.org/10.1097/SLA.0000000000003256

Objective: To define the influence of preoperative immune modulating nutrition (IMN) on postoperative outcomes in patients undergoing surgery for gastrointestinal cancer. Summary background data: Although studies have shown that perioperative IMN... Read More about The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries (2019)
Journal Article
Shrine, N., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C. A., …Wain, L. V. (2019). New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nature Genetics, 51(3), 481-493. https://doi.org/10.1038/s41588-018-0321-7

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of European ancestry, we define 279 lung function signals, 139 of which ar... Read More about New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Evolution of treatment targets in Crohn’s disease (2019)
Journal Article
White, J. R., Jairath, V., & Moran, G. W. (2019). Evolution of treatment targets in Crohn’s disease. Best Practice and Research: Clinical Gastroenterology, 38-39, 1-9. https://doi.org/10.1016/j.bpg.2019.02.001

Crohn’s disease is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract, associated with significantly morbidity due to both symptoms and complications that have a considerable detrimental impact on a patient’s qualit... Read More about Evolution of treatment targets in Crohn’s disease.

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective (2019)
Journal Article
Allison, S. P., & Lobo, D. N. (2020). The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective. Clinical Nutrition, 39(1), 304-305. https://doi.org/10.1016/j.clnu.2019.01.027

Many theories have been advanced concerning the cause of Charlotte Bronte’s death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tubercul... Read More about The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective.

Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease (2019)
Journal Article
Shivaji, U. N., Sharratt, C. L., Thomas, T., Smith, S. C., Iacucci, M., Moran, G. W., …Bhala, N. (2019). Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease. Alimentary Pharmacology and Therapeutics, 49(6), 664-680. https://doi.org/10.1111/apt.15097

Background: Biological therapy is currently widely used to treat inflammatory bowel disease (IBD). Infliximab, adalimumab and golimumab are currently licensed anti-TNF therapies. Biosimilar anti-TNF monoclonal antibodies are increasingly used. Anti-T... Read More about Review article: managing the adverse events caused by anti-TNF therapy in inflammatory bowel disease.

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China (2019)
Journal Article
Shen, T., Liu, Y., Shang, J., Xie, Q., Li, J., Yan, M., …Chen, C. (2019). Incidence and Etiology of Drug-Induced Liver Injury in Mainland China. Gastroenterology, 156(8), 2230-2241.e11. https://doi.org/10.1053/j.gastro.2019.02.002

Background & Aims: We performed a nationwide, retrospective study to determine the incidence and causes of drug-induced liver injury (DILI) in mainland China. Methods: We collected data on a total of 25,927 confirmed DILI cases, hospitalized from... Read More about Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.

Testing for hepatitis C virus infection in UK prisons: what actually happens? (2019)
Journal Article
Jack, K., Thomson, B. J., & Irving, W. L. (2019). Testing for hepatitis C virus infection in UK prisons: what actually happens?. Journal of Viral Hepatitis, 26(6), 644-654. https://doi.org/10.1111/jvh.13071

Prisons are a key demographic in the drive to eradicate hepatitis C virus (HCV) as a major public health threat. We have assessed the impact of the recently introduced national opt-out policy on the current status of HCV testing in 14 prisons in the... Read More about Testing for hepatitis C virus infection in UK prisons: what actually happens?.