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Outputs (549)

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma (2022)
Journal Article
Lee, K. A., Thomas, A. M., Bolte, L. A., Björk, J. R., de Ruijter, L. K., Armanini, F., Asnicar, F., Blanco-Miguez, A., Board, R., Calbet-Llopart, N., Derosa, L., Dhomen, N., Brooks, K., Harland, M., Harries, M., Leeming, E. R., Lorigan, P., Manghi, P., Marais, R., Newton-Bishop, J., …Segata, N. (2022). Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma. Nature Medicine, 28(3), 535-544. https://doi.org/10.1038/s41591-022-01695-5

The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific microbiome characteristics linked to the clinical benefits of ICIs. We pe... Read More about Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma.

Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics (2022)
Journal Article
Bosma, A. L., Ascott, A., Iskandar, R., Farquhar, K., Matthewman, J., Langendam, M. W., Mulick, A., Abuabara, K., Williams, H. C., Spuls, P. I., Langan, S. M., & Middelkamp-Hup, M. A. (2022). Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics. Journal of the European Academy of Dermatology and Venereology, 36(6), 807-819. https://doi.org/10.1111/jdv.18008

Atopic dermatitis is a heterogeneous disease, accompanied by a wide variation in disease presentation and the potential to identify many phenotypes that may be relevant for prognosis and treatment. We aimed to systematically review previously reporte... Read More about Classifying atopic dermatitis: a systematic review of phenotypes and associated characteristics.

The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure (2022)
Journal Article
Gordon, A. L., Rick, C., Juszczak, E., Montgomery, A., Howard, R., Guthrie, B., Lim, W. S., Shenkin, S., Leighton, P., Bath, P. M., Ball, J., Gage, H., Glover, M., Godfrey, M., Hewitt, J., Jaki, T., Lasserson, D., Logan, P., Passmore, P., Quinlan, P., …Tate, V. (2022). The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure. Age and Ageing, 51(3), Article afac052. https://doi.org/10.1093/ageing/afac052

The COVID-19 pandemic resulted in catastrophic levels of morbidity and mortality for care home residents. Despite this, research platforms for COVID-19 in care homes arrived late in the pandemic compared with other care settings. The Prophylactic The... Read More about The COVID-19 pandemic has highlighted the need to invest in care home research infrastructure.

Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials (2022)
Journal Article
Williams, H. C., McPhee, M., Layfield, C., & The UK Dermatology Clinical Trials Network. (2022). Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials. Clinical and Experimental Dermatology, 47(6), 1048-1059. https://doi.org/10.1111/ced.15140

The UK Dermatology Clinical Trials Network (UK DCTN) was formed in 2002 with the aim of developing and supporting high-quality independent national clinical trials that address prioritized research questions for people with skin disease. Its philosop... Read More about Celebrating 20 years of the UK Dermatology Clinical Trials Network. Part 1: Developing and delivering high-quality independent clinical trials.

Has the gout epidemic peaked in the UK? A nationwide cohort study using data from the Clinical Practice Research Datalink, from 1997 to across the COVID-19 pandemic in 2021 (2022)
Journal Article
Abhishek, A., Tata, L. J., Mamas, M., & Avery, A. J. (2022). Has the gout epidemic peaked in the UK? A nationwide cohort study using data from the Clinical Practice Research Datalink, from 1997 to across the COVID-19 pandemic in 2021. Annals of the Rheumatic Diseases, 81(6), 898-899. https://doi.org/10.1136/annrheumdis-2021-221989

Self-targeting of zwitterion-based platforms for nano-antimicrobials and nanocarriers (2022)
Journal Article
Wang, D. Y., Su, L., Yang, G., Ren, Y., Zhang, M., Jing, H., Zhang, X., Bayston, R., van der Mei, H. C., Busscher, H. J., & Shi, L. (2022). Self-targeting of zwitterion-based platforms for nano-antimicrobials and nanocarriers. Journal of Materials Chemistry B, 10(14), 2316-2322. https://doi.org/10.1039/d1tb02647j

Self-targeting antimicrobial platforms have yielded new possibilities for the treatment of infectious biofilms. Self-targeting involves stealth transport through the blood circulation towards an infectious biofilm, where the antimicrobial platform pe... Read More about Self-targeting of zwitterion-based platforms for nano-antimicrobials and nanocarriers.

The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients (2022)
Journal Article
Kouraki, A., Bast, T., Ferguson, E., & Valdes, A. M. (2022). The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients. Scientific Reports, 12(1), Article 943. https://doi.org/10.1038/s41598-022-04781-3

Previous research has established links between chronic pain and impaired cognitive ability, as well as between chronic pain and anxiety, in osteoarthritis. Furthermore, there is evidence linking risk of osteoarthritis to lower educational attainment... Read More about The association of socio-economic and psychological factors with limitations in day-to-day activity over 7 years in newly diagnosed osteoarthritis patients.

Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response (2022)
Journal Article
Turnbull, J., Jha, R. R., Ortori, C. A., Lunt, E., Tighe, P. J., Irving, W. L., Gohir, S. A., Kim, D.-H., Valdes, A. M., Tarr, A. W., Barrett, D. A., & Chapman, V. (2022). Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response. Journal of Infectious Diseases, 225(12), 2142-2154. https://doi.org/10.1093/infdis/jiab632

BACKGROUND: Specialized proresolution molecules (SPMs) halt the transition to chronic pathogenic inflammation. We aimed to quantify serum levels of pro- and anti-inflammatory bioactive lipids in severe acute respiratory syndrome coronavirus 2 (SARS-C... Read More about Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response.