Outputs (59)

Multipotent glia-like stem cells mediate stress adaptation (2015)
Journal Article

The neural crest-derived adrenal medulla is closely related to the sympathetic nervous system; however, unlike neural tissue, it is characterized by high plasticity which suggests the involvement of stem cells. Here, we show that a defined pool of gl... Read More about Multipotent glia-like stem cells mediate stress adaptation.

FKBPL: a marker of good prognosis in breast cancer (2015)
Journal Article

FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL’s prognostic ability in primary breast... Read More about FKBPL: a marker of good prognosis in breast cancer.

A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients (2015)
Journal Article

Modifying induction therapy in acute myeloid leukemia (AML) may improve the remission rate and reduce the risk of relapse, thereby improving survival. Escalation of the daunorubicin dose to 90 mg/m2 has shown benefit for some patient subgroups when c... Read More about A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients.

Applications of Raman micro-spectroscopy to stem cell technology: label-free molecular discrimination and monitoring cell differentiation. (2015)
Journal Article

Stem cell therapy is widely acknowledged as a key medical technology of the 21st century which may provide treatments for many currently incurable diseases. These cells have an enormous potential for cell replacement therapies to cure diseases such a... Read More about Applications of Raman micro-spectroscopy to stem cell technology: label-free molecular discrimination and monitoring cell differentiation..

Prognostic and biological significance of peroxisome proliferator-activated receptor-gamma in luminal breast cancer (2015)
Journal Article

Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations (2015)
Journal Article

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neuron-like cells. Mutations in the RNA- and DNA-binding proteins, fused in sarcoma (FUS) and transactive response DNA-binding protein 43 kDa (TDP-4... Read More about Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.

FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15 (2015)
Journal Article

FBXW7 mutations occur in a variety of human cancers including colorectal cancer (CRC). Elucidating its mechanism of action has become crucial for cancer therapy; however, it is also complicated by the fact that FBXW7 can influence many pathways due t... Read More about FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15.

Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer (2015)
Journal Article

The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily of transcription factors, which exerts anti-proliferative and anti-apoptotic activities. The GR is expressed in a large proportion of breast cancer (BC) although levels... Read More about Clinical and biological significance of glucocorticoid receptor (GR) expression in breast cancer.

Independent replication of a melanoma subtype gene signature and evaluation of its prognostic value and biological correlates in a population cohort (2015)
Journal Article

Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis (2015)
Journal Article