Outputs (488)

An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic staphylococcus aureus infection (2020)
Journal Article
Sweeney, E., Harrington, N. E., Harley Henriques, A. G., Hassan, M. M., Crealock-Ashurst, B., Smyth, A. R., Hurley, M. N., Tormo-Mas, M. Á., & Harrison, F. (2021). An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic staphylococcus aureus infection. Microbiology, 167(1), Article 000987. https://doi.org/10.1099/mic.0.000987

Staphylococcus aureus is the most prevalent organism isolated from the airways of people with cystic fibrosis (CF), predomi-nantly early in life. Yet its role in the pathology of lung disease is poorly understood. In mice, and many experiments using... Read More about An ex vivo cystic fibrosis model recapitulates key clinical aspects of chronic staphylococcus aureus infection.

Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance (2020)
Journal Article
Gale, C., Quigley, M. A., Placzek, A., Knight, M., Ladhani, S., Draper, E. S., Sharkey, D., Doherty, C., Mactier, H., & Kurinczuk, J. J. (2021). Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance. Lancet Child and Adolescent Health, 5(2), 113-121. https://doi.org/10.1016/S2352-4642%2820%2930342-4

Background: Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aime... Read More about Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.

Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure (2020)
Journal Article
Suthaporn, S., Jayaprakasan, K., Thornton, J., Walker, K., Medrano, J. H., Castellanos, M., May, S., Polanski, L., Raine-Fenning, N., & Maalouf, W. E. (2021). Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure. Reproductive BioMedicine Online, 42(3), 595-608. https://doi.org/10.1016/j.rbmo.2020.10.018

Research question
What is the difference in endometrial transcriptomics between women with normal and with low mid-luteal progesterone during the implantation window?

Design
An endometrial biopsy and serum progesterone concentration were taken f... Read More about Suboptimal mid-luteal progesterone concentrations are associated with aberrant endometrial gene expression, potentially resulting in implantation failure.

Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial (2020)
Journal Article
Langton Hewer, S. C., Smyth, A. R., Brown, M., Jones, A. P., Hickey, H., Kenna, D., Ashby, D., Thompson, A., & Williamson, P. R. (2020). Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial. Lancet Respiratory Medicine, 8(10), 975-986. https://doi.org/10.1016/S2213-2600%2820%2930331-3

Background: Chronic pulmonary infection with Pseudomonas aeruginosa is one of the most important causes of mortality and morbidity in cystic fibrosis. If antibiotics are commenced promptly, infection can be eradicated. The aim of the trial was to com... Read More about Intravenous versus oral antibiotics for eradication of Pseudomonas aeruginosa in cystic fibrosis (TORPEDO-CF): a randomised controlled trial.

Ion channels as therapeutic targets in high grade gliomas (2020)
Journal Article
Smith, S., Griffin, M., & Khan, R. (2020). Ion channels as therapeutic targets in high grade gliomas. Cancers, 12(10), Article 3068. https://doi.org/10.3390/cancers12103068

Abstract: Glioblastoma multiforme (GBM) is a lethal brain cancer with an average survival of 14-15 months with maximal treatment. High grade gliomas (HGG) form a leading cause of CNS cancer-related death in children and adults due to the aggressive n... Read More about Ion channels as therapeutic targets in high grade gliomas.

Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice (2020)
Journal Article
Morgan, H. L., Aljumah, A., Rouillon, C., & Watkins, A. J. (2021). Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice. Placenta, 103, 124-133. https://doi.org/10.1016/j.placenta.2020.10.020

Introduction
Paternal low-protein diet can alter sperm methylation status, fetal growth and program offspring ill-health, however its impact on the placenta remains poorly defined. Here we examine the influence paternal low-protein diet has on fetal... Read More about Paternal low protein diet and the supplementation of methyl-donors impact fetal growth and placental development in mice.

Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial (2020)
Journal Article
Fleminger, J., Seed, P., Smith, A., Dixon, P., Juszczak, E., Chambers, J., Dorling, J., Williamson, C., Thornton, J., & Chappell, L. (2021). Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial. BJOG: An International Journal of Obstetrics and Gynaecology, 128(6), 1066-1075. https://doi.org/10.1111/1471-0528.16567

Objective: To evaluate whether a particular group of women with intrahepatic cholestasis of pregnancy (ICP), based on their presenting characteristics, would benefit from treatment with ursodeoxycholic acid (UDCA). Design: Secondary analysis of the P... Read More about Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial.

TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML (2020)
Journal Article
Vadakekolathu, J., Lai, C., Reeder, S., Church, S. E., Hood, T., Lourdusamy, A., Rettig, M. P., Aldoss, I., Advani, A. S., Godwin, J., Wieduwilt, M. J., Arellano, M., Muth, J., Yau, T. O., Ravandi, F., Sweet, K., Altmann, H., Foulds, G. A., Stölzel, F., Middeke, J. M., …Rutella, S. (2020). TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML. Blood Advances, 4(20), 5011-5024. https://doi.org/10.1182/bloodadvances.2020002512

Somatic TP53 mutations and 17p deletions with genomic loss of TP53 occur in 37% to 46% of acute myeloid leukemia (AML) with adverse-risk cytogenetics and correlate with primary induction failure, high risk of relapse, and dismal prognosis. Herein, we... Read More about TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML.

Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours (2020)
Journal Article
McCrorie, P., Mistry, J., Taresco, V., Lovato, T., Fay, M., Ward, I., Ritchie, A. A., Clarke, P. A., Smith, S. J., Marlow, M., & Rahman, R. (2020). Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours. European Journal of Pharmaceutics and Biopharmaceutics, 157, 108-120. https://doi.org/10.1016/j.ejpb.2020.10.005

Glioblastoma is a malignant brain tumour with a median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence is inevitable. To try combating the disease at a stage of low residual tu... Read More about Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours.

Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy (2020)
Journal Article
Moraitis, A. A., Shreeve, N., Sovio, U., Brocklehurst, P., Heazell, A. E. P., Thornton, J. G., Robson, S. C., Papageorghiou, A., & Smith, G. C. (2020). Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy. PLoS Medicine, 17(10), Article e1003190. https://doi.org/10.1371/journal.pmed.1003190

Background
The effectiveness of screening for macrosomia is not well established. One of the critical elements of an effective screening program is the diagnostic accuracy of a test at predicting the condition. The objective of this study is to inve... Read More about Universal third-trimester ultrasonic screening using fetal macrosomia in the prediction of adverse perinatal outcome: A systematic review and meta-analysis of diagnostic test accuracy.