Outputs (488)

The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring (2020)
Journal Article
Aljahdali, A., Airina, R. K. R. I., Velazquez, M. A., Sheth, B., Wallen, K., Osmond, C., Watkins, A. J., Eckert, J. J., Smyth, N. R., & Fleming, T. P. (2020). The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring. Human Reproduction, 35(11), 2497–2514. https://doi.org/10.1093/humrep/deaa205

Study question: Do the long-term health outcomes following IVF differ depending upon the duration of embryo culture before transfer?

Summary answer: Using a mouse model, we demonstrate that in male but not female offspring, adverse cardiovascular... Read More about The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspring.

Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro (2020)
Journal Article
Velickovic, K., Lugo Leija, H. A., Surrat, A., Kim, D.-H., Sacks, H., Symonds, M. E., & Sottile, V. (2020). Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro. Cellular Physiology and Biochemistry, 54(5), 917-927. https://doi.org/10.33594/000000278

Background/Aims: Glutamine is the most abundant amino acid in the body and has a metabolic role as a precursor for protein, amino sugar and nucleotide synthesis. After glucose, glutamine is the main source of energy in cells and has recently been sho... Read More about Targeting glutamine synthesis inhibits stem cell adipogenesis in vitro.

Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia (2020)
Journal Article
Lugo Leija, H. A., Velickovic, K., Bloor, I., Sacks, H., Symonds, M. E., & Sottile, V. (2020). Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia. Journal of Cellular and Molecular Medicine, 24(19), 11434-11444. https://doi.org/10.1111/jcmm.15749

Beige adipocytes possess the morphological and biochemical characteristics of brown adipocytes, including the mitochondrial uncoupling protein (UCP)1. Mesenchymal stem cells (MSCs) are somatic multipotent progenitors which differentiate into lipid-la... Read More about Cold-induced beigeing of stem cell-derived adipocytes is not fully reversible after return to normothermia.

How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey (2020)
Journal Article
Smith, S., Rowbotham, N., Davies, G., Gathercole, K., Collins, S. J., Elliott, Z., Herbert, S., Allen, L., Ng, C., & Smyth, A. (2020). How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey. BMJ Open Respiratory Research, 7(1), Article e000614. https://doi.org/10.1136/bmjresp-2020-000614

Introduction Relieving gastrointestinal (GI) symptoms was identified as a ‘top ten’ priority by our James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF). We conducted an online survey to find out more about the effect of GI sympto... Read More about How can we relieve gastrointestinal symptoms in people with cystic fibrosis? An international qualitative survey.

Treatment of pulmonary exacerbations in cystic fibrosis (2020)
Journal Article
Ng, C., Nadig, T., Smyth, A. R., & Flume, P. (2020). Treatment of pulmonary exacerbations in cystic fibrosis. Current Opinion in Pulmonary Medicine, 26(6), 679-684. https://doi.org/10.1097/mcp.0000000000000730

Purpose of review

This review will discuss the challenges of defining a pulmonary exacerbations in cystic fibrosis and the key pathogens, which contribute. It will discuss the treatment options currently available and the importance of preventing... Read More about Treatment of pulmonary exacerbations in cystic fibrosis.

International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019 (2020)
Journal Article
Evangelidis, N., Tong, A., Howell, M., Teixeira-Pinto, A., Elliott, J. H., Azevedo, L. C., Bersten, A., Cervantes, L., Chew, D. P., Crowe, S., Douglas, I. S., Flemyng, E., Horby, P., Lee, J., Lorca, E., Lynch, D., Marshall, J. C., McKenzie, A., Mehta, S., Mer, M., …Craig, J. C. (2020). International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019. Critical Care Medicine, 48(11), 1612-1621. https://doi.org/10.1097/ccm.0000000000004584

Objectives:

There are over 4,000 trials conducted in people with coronavirus disease 2019. However, the variability of outcomes and the omission of patient-centered outcomes may diminish the impact of these trials on decision-making. The aim of th... Read More about International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019.

Core Outcomes Set for Trials in People With Coronavirus Disease 2019 (2020)
Journal Article
Tong, A., Elliott, J. H., Azevedo, L. C., Baumgart, A., Bersten, A., Cervantes, L., Chew, D. P., Cho, Y., Cooper, T., Crowe, S., Douglas, I. S., Evangelidis, N., Flemyng, E., Hannan, E., Horby, P., Howell, M., Lee, J., Liu, E., Lorca, E., Lynch, D., …COVID-19-Core Outcomes Set (COS) Workshop Investigators. (2020). Core Outcomes Set for Trials in People With Coronavirus Disease 2019. Critical Care Medicine, 48(11), 1622-1635. https://doi.org/10.1097/ccm.0000000000004585

Objectives:
The outcomes reported in trials in coronavirus disease 2019 are extremely heterogeneous and of uncertain patient relevance, limiting their applicability for clinical decision-making. The aim of this workshop was to establish a core outc... Read More about Core Outcomes Set for Trials in People With Coronavirus Disease 2019.

Impact of COVID-19 Pandemic on Surgical Neuro-oncology Multi-Disciplinary Team Decision Making – A National Survey (COVID-CNSMDT Study) (2020)
Journal Article
Price, S. J., Joannides, A. J., Plaha, P., Afshari, F. T., Albanese, E., Barua, N. U., Wee Chan, H., Critchley, G., Flannery, T., Fountain, D. M., Mathew, R., Piper, R. J., Poon, M. T., Rajaraman, C., Rominiyi, O., Smith, S., Solomou, G., Solth, A., Surash, S., Wykes, V., …Jenkinson, M. D. (2020). Impact of COVID-19 Pandemic on Surgical Neuro-oncology Multi-Disciplinary Team Decision Making – A National Survey (COVID-CNSMDT Study). BMJ Open, 10(8), Article e040898. https://doi.org/10.1136/bmjopen-2020-040898

Objectives Pressures on healthcare systems due to COVID-19 has impacted patients without COVID-19 with surgery disproportionally affected. This study aims to understand the impact on the initial management of patients with brain tumours by measuring... Read More about Impact of COVID-19 Pandemic on Surgical Neuro-oncology Multi-Disciplinary Team Decision Making – A National Survey (COVID-CNSMDT Study).

What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment? (2020)
Journal Article
Calthorpe, R. J., Smith, S. J., Rowbotham, N. J., Leighton, P. A., Davies, G., Daniels, T., Gathercole, K., Allen, L., Elliott, Z. C., & Smyth, A. R. (2020). What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?. BMJ Open Respiratory Research, 7(1), Article e000601. https://doi.org/10.1136/bmjresp-2020-000601

Introduction: “What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?” was identified as one of the James Lind Alliance Priority Setting Partnership’s top 10 research q... Read More about What effective ways of motivation, support and technologies help people with cystic fibrosis improve and sustain adherence to treatment?.

Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles (2020)
Other
Jain, A., Trindade, G., Hicks, J. M., Potts, J. C., Rahman, R., Hague, R., Amabilino, D. B., Pérez-García, L., & Rawson, F. Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles

Protein orientation in nanoparticle-protein conjugates plays a crucial role in binding to cell receptors and ultimately, defines their targeting efficiency. Therefore, understanding fundamental aspects of the role of protein orientation upon adsorpti... Read More about Modulating the Biological Function of Protein by Tailoring the Adsorption Orientation on Nanoparticles.