Outputs (38)

Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors (2016)
Journal Article
Torchia, J., Golbourn, B., Feng, S., Ching Ho, K., Sin-Chan, P., Vasiljevic, A., …Huang, A. (2016). Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell, 30(6), 891-908. https://doi.org/10.1016/j.ccell.2016.11.003

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we anal... Read More about Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors.

Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? (2016)
Journal Article
Aldiss, P., Budge, H., & Symonds, M. E. (2016). Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?. Cardiovascular Endocrinology, 5(4), 155-156. https://doi.org/10.1097/XCE.0000000000000089

Maintenance of thermal homeostasis within a tight range is regulated not only by a variety of internal and external cues but also by sex and biological age. The major organ responsible for adaptive thermogenesis is brown adipose tissue (BAT) and the... Read More about Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause?.

‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk (2016)
Journal Article
Aldiss, P., Davies, G., Woods, R., Budge, H., Sacks, H. S., & Symonds, M. E. (2017). ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk. International Journal of Cardiology, 228, https://doi.org/10.1016/j.ijcard.2016.11.074

Excess visceral adiposity, in particular that located adjacent to the heart and coronary arteries is associated with increased cardiovascular risk. In the pathophysiological state, dysfunctional adipose tissue secretes an array of factors modulating... Read More about ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk.

Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study (2016)
Journal Article
Barr, H. L., Halliday, N., Barrett, D. A., Williams, P., Forrester, D. L., Peckham, D., …Fogarty, A. W. (2017). Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study. Journal of Cystic Fibrosis, 16(2), 230-238. https://doi.org/10.1016/j.jcf.2016.10.005

Background Pulmonary P. aeruginosa infection is associated with poor outcomes in cystic fibrosis (CF) and early diagnosis is challenging, particularly in those who are unable to expectorate sputum. Specific P. aeruginosa 2-alkyl-4-quinolones are det... Read More about Diagnostic and prognostic significance of systemic alkyl quinolones for P. aeruginosa in cystic fibrosis: a longitudinal study.

Random allocation of blastomere descendants to the trophectoderm and ICM of the bovine blastocyst (2016)
Journal Article
Sepulveda-Rincon, L. P., Dube, D., Adenot, P., Laffont, L., Ruffini, S., Gall, L., …Maalouf, W. E. (2016). Random allocation of blastomere descendants to the trophectoderm and ICM of the bovine blastocyst. Biology of Reproduction, 95(6), 1-10. https://doi.org/10.1095/biolreprod.116.141200

The first lineage specification during mammalian embryo development can be visually distinguished at the blastocyst stage. Two cell lineages are observed on the embryonic-abembryonic axis of the blastocyst: the inner cell mass and the trophectoderm.... Read More about Random allocation of blastomere descendants to the trophectoderm and ICM of the bovine blastocyst.

Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice (2016)
Journal Article
Zurkinden, L., Mansour, Y., Rohrbach, B., Vogt, B., Mistry, H. D., & Escher, G. (2016). Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice. FEBS Open Bio, 6(10), https://doi.org/10.1002/2211-5463.12123

Sterol 27-hydroxylase (CYP27A1) is involved in bile acid synthesis and cholesterol homoeostasis. Cyp27a1(?/?)/Apolipoprotein E(?/?) double knockout mice (DKO) fed a western diet failed to develop atherosclerosis. Caveolin-1 (CAV-1), the main componen... Read More about Hepatic caveolin-1 is enhanced in Cyp27A1/ApoE double knockout mice.

Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study) (2016)
Journal Article
Vidler, M., Magee, L. A., von Dadelszen, P., Rey, E., Ross, S., Asztalos, E., …Moutquin, J. (2016). Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study). European Journal of Obstetrics and Gynecology and Reproductive Biology, 206, 105-113. https://doi.org/10.1016/j.ejogrb.2016.07.509

Objective: To compare women’s views about blood pressure (BP) control in CHIPS (Control of Hypertension In Pregnancy Study) (NCT01192412). Design: Quantitative and qualitative analysis of questionnaire responses. Setting: International randomised... Read More about Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study).

Circadian changes and sex-related differences in fetal heart rate parameters (2016)
Journal Article
Kapaya, H., Broughton Pipkin, F., Hayes-Gill, B., & Loughna, P. V. (2016). Circadian changes and sex-related differences in fetal heart rate parameters. Maternal Health, Neonatology and Perinatology, 2(1), https://doi.org/10.1186/s40748-016-0037-6

BACKGROUND: Previous researchers have studied circadian changes in the fetal heart rate (FHR) on small sample sizes and in a strictly controlled environment. This study was undertaken to investigate these changes during the late second and third trim... Read More about Circadian changes and sex-related differences in fetal heart rate parameters.

Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF (2016)
Journal Article
Massey, A., Campbell, B. K., Raine-Fenning, N., Pincott-Allen, C., Perry, J., & Vedhara, K. (2016). Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF. Psychoneuroendocrinology, 74, https://doi.org/10.1016/j.psyneuen.2016.08.027

Evidence for an association between cortisol and clinical pregnancy in women undergoing In Vitro Fertilisation (IVF) is mixed with previous studies relying exclusively on short term measures of cortisol in blood, saliva, urine, and/or follicular flui... Read More about Relationship between hair and salivary cortisol and pregnancy in women undergoing IVF.

Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma (2016)
Journal Article
Vergnes, L., Davies, G. R., Lin, J. Y., Yeh, M. W., Livhits, M. J., Harari, A., …Reue, K. (2016). Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma. Journal of Clinical Endocrinology and Metabolism, 101(11), https://doi.org/10.1210/jc.2016-2670

Context: Patients with pheochromocytoma (pheo) show presence of multilocular adipocytes that express uncoupling protein (UCP) 1 within periadrenal (pADR) and omental (OME) fat depots. It has been hypothesized that this is due to adrenergic stimula... Read More about Adipocyte browning and higher mitochondrial function in peri-adrenal but not subcutaneous fat in pheochromocytoma.