Outputs (196)

Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties (2020)
Journal Article
Alobaid, M. A., Richards, S.-J., Alexander, M. R., Gibson, M. I., & Ghaemmaghami, A. M. (2020). Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties. Materials Today Bio, 8, Article 100080. https://doi.org/10.1016/j.mtbio.2020.100080

© 2020 The Authors New strategies for immune modulation have shown real promise in regenerative medicine as well as the fight against autoimmune diseases, allergies, and cancer. Dendritic cells (DCs) are gatekeepers of the immune system and their abi... Read More about Developing immune-regulatory materials using immobilized monosaccharides with immune-instructive properties.

Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click (2020)
Journal Article
Harvey, D., Bray, G., Zamberlan, F., Amer, M., Goodacre, S. L., & Thomas, N. R. (2020). Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click. Macromolecular Bioscience, https://doi.org/10.1002/mabi.202000255

Recombinant spider silk has the potential to provide a new generation of biomaterial scaffolds as a result of its degree of biocompatibility and lack of immunogenicity. These recombinant biomaterials are, however, reported to exhibit poor cellular ad... Read More about Cyclo(RGDfK) Functionalized Spider Silk Cell Scaffolds: Significantly Improved Performance in Just One Click.

The effect of agri-environment schemes on bees on Shropshire farms (2020)
Journal Article
Crowther, L. I., & Gilbert, F. (2020). The effect of agri-environment schemes on bees on Shropshire farms. Journal for Nature Conservation, 58, Article 125895. https://doi.org/10.1016/j.jnc.2020.125895

© 2020 The decline of bees and other invertebrate pollinators is cause for global concern, with modern intensive agriculture identified as a key driver. Government-run agri-environment schemes (AES) have the potential to restore the local landscape t... Read More about The effect of agri-environment schemes on bees on Shropshire farms.

Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR (2020)
Journal Article
Grossman, S., Soukarieh, F., Richardson, W., Liu, R., Mashabi, A., Emsley, J., Williams, P., Cámara, M., & Stocks, M. J. (2020). Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. European Journal of Medicinal Chemistry, 208, Article 112778. https://doi.org/10.1016/j.ejmech.2020.112778

© 2020 The Authors Rising numbers of cases of multidrug- and extensively drug-resistant Pseudomonas aeruginosa over recent years have created an urgent need for novel therapeutic approaches to cure potentially fatal infections. One such approach is v... Read More about Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.

12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies (2020)
Journal Article
Jacques, M. F., Onambele-Pearson, G. L., Reeves, N. D., Stebbings, G. K., Dawson, E. A., Stockley, R. C., Edwards, B., & Morse, C. I. (2022). 12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies. Disability and Rehabilitation, 44(10), 1847-1854. https://doi.org/10.1080/09638288.2020.1808087

Purpose
Muscular dystrophy (MD) is an umbrella term for muscle wasting conditions, for which longitudinal changes in function and body composition are well established in children with Duchenne (DMD), however, changes in adults with DMD and Beckers... Read More about 12-Month changes of muscle strength, body composition and physical activity in adults with dystrophinopathies.

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients (2020)
Journal Article
Funnell, S. G., Dowling, W. E., Muñoz-Fontela, C., Gsell, P. S., Ingber, D. E., Hamilton, G. A., Delang, L., Rocha-Pereira, J., Kaptein, S., Dallmeier, K. H., Neyts, J., Rosenke, K., de Wit, E., Feldmann, H., Maisonnasse, P., Le Grand, R., Frieman, M. B., & Coleman, C. M. (2020). Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients. Nature Communications, 11(1), Article 4253. https://doi.org/10.1038/s41467-020-17907-w

Optical Mapping of cAMP Signaling at the Nanometer Scale (2020)
Journal Article
Bock, A., Annibale, P., Konrad, C., Hannawacker, A., Anton, S. E., Maiellaro, I., Zabel, U., Sivaramakrishnan, S., Falcke, M., & Lohse, M. J. (2020). Optical Mapping of cAMP Signaling at the Nanometer Scale. Cell, 182(6), 1519-1530.e17. https://doi.org/10.1016/j.cell.2020.07.035

Cells relay a plethora of extracellular signals to specific cellular responses by using only a few second messengers, such as cAMP. To explain signaling specificity, cAMP-degrading phosphodiesterases (PDEs) have been suggested to confine cAMP to dist... Read More about Optical Mapping of cAMP Signaling at the Nanometer Scale.

Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo. (2020)
Journal Article
Weston, S., Coleman, C., Haupt, R., Logue, J., Matthews, K., Li, Y., Reyes, H., Weiss, S., & Frieman, M. (2020). Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo. Journal of Virology, 94(21), Article e01218-20. https://doi.org/10.1128/JVI.01218-20

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the end of 2019 and has rapidly caused a pandemic, with over 20 million recorded COVID-19 cases in August 2020 (https://covid19.who.int/). There are no FDA-approved anti... Read More about Broad anti-coronaviral activity of FDA approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo..

Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV (2020)
Journal Article
Weston, S., Coleman, C. M., Haupt, R., Logue, J., Matthews, K., Li, Y., Reyes, H. M., Weiss, S. R., & Frieman, M. B. (2020). Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV. Journal of Virology, 94(21), Article 10.1128/jvi.01218-20. https://doi.org/10.1128/jvi.01218-20

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in China at the end of 2019 and has rapidly caused a pandemic, with over 20 million recorded COVID-19 cases in August 2020 (https://covid19.who.int/). There are no FDA-approved anti... Read More about Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV.

Mechanistic insights into Lhr helicase function in DNA repair (2020)
Journal Article
Buckley, R., Kramm, K., Cooper, C. D. O., Grohmann, D., & Bolt, E. L. (2020). Mechanistic insights into Lhr helicase function in DNA repair. Biochemical Journal, 477(16), 2935–2947. https://doi.org/10.1042/bcj20200379

The DNA helicase Lhr is present throughout archaea, including in the Asgard and Nanoarchaea, and has homologues in bacteria and eukaryotes. It is thought to function in DNA repair but in a context that is not known. Our data show that archaeal Lhr pr... Read More about Mechanistic insights into Lhr helicase function in DNA repair.