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Outputs (196)

Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV (2020)
Journal Article
Mosa, A. I., AbouHaidar, M. G., Urbanowicz, R. A., Tavis, J. E., Ball, J. K., & Feld, J. J. (2020). Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV. Virology Journal, 17, Article 140. https://doi.org/10.1186/s12985-020-01408-9

Despite available treatments, a prophylactic HCV vaccine is needed to achieve elimination targets. HCV vaccine development has faltered largely because the extreme diversity of the virus limits the protective breadth of vaccine elicited antibodies. I... Read More about Role of HVR1 sequence similarity in the cross-genotypic neutralization of HCV.

Historical Introgression from Wild Relatives Enhanced Climatic Adaptation and Resistance to Pneumonia in Sheep (2020)
Journal Article
Cao, Y. H., Xu, S. S., Shen, M., Chen, Z. H., Gao, L., Lv, F. H., Xie, X. L., Wang, X. H., Yang, H., Liu, C. B., Zhou, P., Wan, P. C., Zhang, Y. S., Yang, J. Q., Pi, W. H., Hehua, E., Berry, D. P., Barbato, M., Esmailizadeh, A., Nosrati, M., …Li, M. H. (2021). Historical Introgression from Wild Relatives Enhanced Climatic Adaptation and Resistance to Pneumonia in Sheep. Molecular Biology and Evolution, 38(3), 838-855. https://doi.org/10.1093/molbev/msaa236

How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is imp... Read More about Historical Introgression from Wild Relatives Enhanced Climatic Adaptation and Resistance to Pneumonia in Sheep.

Enterovirus subtyping in a routine UK laboratory setting between 2013 and 2017 (2020)
Journal Article
Howson-Wells, H. C., Winckles, S., Aliker, C., Tarr, A. W., Irving, W. L., Clark, G., & McClure, C. P. (2020). Enterovirus subtyping in a routine UK laboratory setting between 2013 and 2017. Journal of Clinical Virology, 132, Article 104646. https://doi.org/10.1016/j.jcv.2020.104646

© 2020 Elsevier B.V. Background: Human enteroviruses (EV) are the leading cause of viral meningitis. EV genotyping is predominantly performed through amplification and sequencing of viral capsid protein-1 (VP1), frequently by national reference labor... Read More about Enterovirus subtyping in a routine UK laboratory setting between 2013 and 2017.

Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas (2020)
Journal Article
Blokpoel Ferreras, L. A., Scott, D., Vazquez Reina, S., Roach, P., Torres, T. E., Goya, G. F., Shakesheff, K. M., & Dixon, J. E. (2020). Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas. Advanced Biosystems, 4(10), Article 2000162. https://doi.org/10.1002/adbi.202000162

© 2020 The Authors. Published by Wiley-VCH GmbH Nanoparticles (NPs) are increasingly being developed as biomedical platforms for drug/nucleic acid delivery and imaging. However, in biological fluids, NPs interact with a wide range of proteins that fo... Read More about Enhanced Cellular Transduction of Nanoparticles Resistant to Rapidly Forming Plasma Protein Coronas.

Spatial and seasonal patterns of communal latrine use by spotted hyenas (Crocuta crocuta) reflect a seasonal resource defense strategy (2020)
Journal Article
Vitale, J. D., Jordan, N. R., Gilfillan, G. D., McNutt, J. W., & Reader, T. (2020). Spatial and seasonal patterns of communal latrine use by spotted hyenas (Crocuta crocuta) reflect a seasonal resource defense strategy. Behavioral Ecology and Sociobiology, 74(10), Article 120. https://doi.org/10.1007/s00265-020-02895-0

© 2020, Springer-Verlag GmbH Germany, part of Springer Nature. Abstract: Communal marking sites, or latrines, appear to play an important role in intraspecific communication and social dynamics in a wide range of mammal species. The spatial distribut... Read More about Spatial and seasonal patterns of communal latrine use by spotted hyenas (Crocuta crocuta) reflect a seasonal resource defense strategy.

East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol (2020)
Journal Article
Hall, M., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., Greenhaff, P., Das Nair, R., Doherty, M., Walsh, D. A., & Abhishek, A. (2020). East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol. BMJ Open, 10(9), Article e037760. https://doi.org/10.1136/bmjopen-2020-037760

© 2020 BMJ Open Introduction Knee pain due to osteoarthritis (OA) is a common cause of disability. The UK National Institute for Health and Care Excellence OA guidelines recommend education, exercise and weight loss advice (if overweight) as core int... Read More about East Midlands knee pain multiple randomised controlled trial cohort study: cohort establishment and feasibility study protocol.

The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol (2020)
Journal Article
Hall, M. C., Fuller, A., Nomikos, P. A., Millar, B., Ogollah, R., Valdes, A., Greenhaff, P., Das Nair, R., Doherty, M., Walsh, D. A., & Abhishek, A. (2020). The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol. BMJ Open, 10(9), Article e037760

Introduction: Knee pain and osteoarthritis (OA) are a common cause of disability. The UK National Institute of Health and Care Excellence (NICE) OA guidelines recommend education, exercise and weight-loss advice (if overweight) as core interventions... Read More about The East Midlands Knee Pain Multiple Randomised Controlled Trial Cohort Study: Cohort Establishment and Feasibility study protocol.

Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation (2020)
Journal Article
Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H. E. L., Layfield, R., & Mitchell, N. J. (2020). Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation. Angewandte Chemie International Edition, 59(52), 23659-23667. https://doi.org/10.1002/anie.202006260

© 2020 The Authors. Published by Wiley-VCH GmbH The development of site-selective chemistry targeting the canonical amino acids enables the controlled installation of desired functionalities into native peptides and proteins. Such techniques facilita... Read More about Site-Selective Modification of Peptides and Proteins via Interception of Free-Radical-Mediated Dechalcogenation.

Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization (2020)
Journal Article
Pierce, B. G., Keck, Z. Y., Wang, R., Lau, P., Garagusi, K., Elkholy, K., Toth, E. A., Urbanowicz, R. A., Guest, J. D., Agnihotri, P., Kerzic, M. C., Marin, A., Andrianov, A. K., Ball, J. K., Mariuzza, R. A., Fuerst, T. R., & Foung, S. K. (2020). Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization. Journal of Virology, 94(22), https://doi.org/10.1128/JVI.00704-20

Copyright © 2020 American Society for Microbiology. An effective vaccine for hepatitis C virus (HCV) is a major unmet need, and it requires an antigen that elicits immune responses to key conserved epitopes. Based on structures of antibodies targetin... Read More about Structure-Based Design of Hepatitis C Virus E2 Glycoprotein Improves Serum Binding and Cross-Neutralization.