Skip to main content

Research Repository

Advanced Search

Outputs (213)

Comparative morphological trade-offs between pre- and post-copulatory sexual selection in Giant hissing cockroaches (Tribe: Gromphadorhini) (2016)
Journal Article
Durrant, K. L., Skicko, I. M., Sturrock, C., & Mowles, S. L. (in press). Comparative morphological trade-offs between pre- and post-copulatory sexual selection in Giant hissing cockroaches (Tribe: Gromphadorhini). Scientific Reports, 6, https://doi.org/10.1038/srep36755

Sperm competition theory predicts that animals face a trade-off between investment in weaponry and investment in ejaculate composition. Within the Madagascan giant hissing cockroaches (Tribe Gromphadorhini) differences in morphology exist that may in... Read More about Comparative morphological trade-offs between pre- and post-copulatory sexual selection in Giant hissing cockroaches (Tribe: Gromphadorhini).

Human Adaptation of Ebola Virus during the West African Outbreak (2016)
Journal Article
Urbanowicz, R. A., McClure, C. P., Sakuntabhai, A., Sall, A. A., Kobinger, G., Müller, M. A., Holmes, E. C., Rey, F. A., Simon-Loriere, E., & Ball, J. K. (2016). Human Adaptation of Ebola Virus during the West African Outbreak. Cell, 167(4), 1079-1087.e5. https://doi.org/10.1016/j.cell.2016.10.013

The 2013–2016 outbreak of Ebola virus (EBOV) in West Africa was the largest recorded. It began following the cross-species transmission of EBOV from an animal reservoir, most likely bats, into humans, with phylogenetic analysis revealing the cocircul... Read More about Human Adaptation of Ebola Virus during the West African Outbreak.

Insecticide resistance mediated 1 by an exon skipping event (2016)
Journal Article
Berger, M., Puinean, A. M., Randall, E., Zimmer, C. T., Silva, W. M., Bielza, P., Field, L. M., Hughes, D., Mellor, I. R., Hassani-Pak, K., Siqueira, H. A., Williamson, M. S., & Bass, C. (2016). Insecticide resistance mediated 1 by an exon skipping event. Molecular Ecology, 25(22), https://doi.org/10.1111/mec.13882

Many genes increase coding capacity by alternate exon usage. The gene encoding the insect nicotinic acetylcholine receptor (nAChR) a6 subunit, target of the bio-insecticide spinosad, is one example of this and expands protein diversity via alternativ... Read More about Insecticide resistance mediated 1 by an exon skipping event.

Making Silicone Rubber Highly Resistant to Bacterial Attachment Using Thiol-ene Grafting (2016)
Journal Article
Magennis, E. P., Hook, A. L., Williams, P., & Alexander, M. R. (2016). Making Silicone Rubber Highly Resistant to Bacterial Attachment Using Thiol-ene Grafting. ACS Applied Materials and Interfaces, 8(45), 30780-30787. https://doi.org/10.1021/acsami.6b10986

Biomedical devices are indispensable in modern medicine yet offer surfaces that promote bacterial attachment and biofilm formation, resulting in acute and chronic healthcare-associated infections. We have developed a simple method to graft acrylates... Read More about Making Silicone Rubber Highly Resistant to Bacterial Attachment Using Thiol-ene Grafting.

The amino-terminal domain of the androgen receptor co-opts extracellular signal-regulated kinase (ERK) docking sites in ELK1 protein to induce sustained gene activation that supports prostate cancer cell growth (2016)
Journal Article
Rosati, R., Patki, M., Chari, V., Dakshnamurthy, S., McFall, T., Saxton, J., Kidder, B. L., Shaw, P. E., & Ratnam, M. (2016). The amino-terminal domain of the androgen receptor co-opts extracellular signal-regulated kinase (ERK) docking sites in ELK1 protein to induce sustained gene activation that supports prostate cancer cell growth. Journal of Biological Chemistry, 291(50), 25983-25998. https://doi.org/10.1074/jbc.M116.745596

The ETS domain transcription factor ELK1 is in a repressive association with growth genes and is transiently activated through phosphorylation by ERK1/2. In prostate cancer (PCa) cells the androgen receptor (AR) is recruited by ELK1, via its amino-te... Read More about The amino-terminal domain of the androgen receptor co-opts extracellular signal-regulated kinase (ERK) docking sites in ELK1 protein to induce sustained gene activation that supports prostate cancer cell growth.

CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome (2016)
Journal Article
Coleman, C. M., Sisk, J. M., Halasz, G., Zhong, J., Beck, S. E., Matthews, K. L., Venkataraman, T., Rajagopalan, S., Kyratsous, C. A., & Frieman, M. B. (2017). CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome. Journal of Virology, 91(1), https://doi.org/10.1128/jvi.01825-16

© 2016 American Society for Microbiology. Middle East respiratory syndrome coronavirus (MERS-CoV) is an important emerging pathogen that was first described in 2012. While the cell surface receptor for MERS-CoV has been identified as dipeptidyl pepti... Read More about CD8 + T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome.

cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons (2016)
Journal Article
Maiellaro, I., Lohse, M., Kittel, R., & Calebiro, D. (2016). cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons. Cell Reports, 17(5), 1238-1246. https://doi.org/10.1016/j.celrep.2016.09.090

The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling exis... Read More about cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons.

STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways (2016)
Journal Article
Ho, J., Pelzel, C., Begitt, A., Mee, M., Elsheikha, H. M., Scott, D. J., & Vinkemeier, U. (2016). STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways. PLoS Biology, 14(10), 1-27. https://doi.org/10.1371/journal.pbio.2000117

STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IF... Read More about STAT2 is a pervasive cytokine regulator due to its inhibition of STAT1 in multiple signaling pathways.

Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection (2016)
Journal Article
Chukwuanukwu, R. C., Onyenekwe, C. C., Martinez-Pomares, L., Flynn, R. J., Singh, S., Amilo, G. I., Agbakoba, N. R., & Okoye, J. O. (in press). Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection. Clinical and Experimental Immunology, 187(2), https://doi.org/10.1111/cei.12861

Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African reg... Read More about Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection.