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Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats (2016)
Journal Article
Carter, J. J., Fretwell, L., & Woolard, J. (2017). Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats. FASEB Journal, 31(3), 1193-1203. https://doi.org/10.1096/fj.201600749r

VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms invo... Read More about Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats.

A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease (2016)
Journal Article
Barron, M., Gartlon, J., Dawson, L. A., Atkinson, P. J., & Pardon, M.-C. (2017). A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease. Experimental Gerontology, 94, 103-107. https://doi.org/10.1016/j.exger.2016.12.006

Alzheimer's disease (AD), the predominant form of dementia, is highly correlated with the abnormal hyperphosphorylation and aggregation of tau. Immune responses are key drivers of AD and how they contribute to tau pathology in human disease remains l... Read More about A state of delirium: deciphering the effect of inflammation on tau pathology in Alzheimer's disease.

The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover (2016)
Journal Article
Zhou, L., Zhang, L.-H., Cámara, M., & He, Y.-W. (2017). The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover. Trends in Microbiology, 25(4), https://doi.org/10.1016/j.tim.2016.11.013

The diffusible signaling factor (DSF)-based quorum sensing (QS) system has emerged as a widely conserved cell–cell communication mechanism in Gram-negative bacteria. Typically, signals from the DSF family are cis-2-unsaturated fatty acids which regul... Read More about The DSF family of quorum sensing signals: diversity, biosynthesis, and turnover.

Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition (2016)
Journal Article
Kachel, H. S., Patel, R. N., Franzyk, H., & Mellor, I. R. (2016). Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition. Scientific Reports, 6, https://doi.org/10.1038/srep38116

Philanthotoxin-433 (PhTX-433) is an active component of the venom from the Egyptian digger wasp, Philanthus triangulum. PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity two synthetic analogues, PhTX-343 and P... Read More about Block of nicotinic acetylcholine receptors by philanthotoxins is strongly dependent on their subunit composition.

No evidence of local adaptation of immune responses to Gyrodactylus in three-spined stickleback (Gasterosteus aculeatus) (2016)
Journal Article
Robertson, S., Bradley, J. E., & MacColl, A. D. (2017). No evidence of local adaptation of immune responses to Gyrodactylus in three-spined stickleback (Gasterosteus aculeatus). Fish and Shellfish Immunology, 60, 275-281. https://doi.org/10.1016/j.fsi.2016.11.058

© 2016 The Authors Parasitism represents one of the most widespread lifestyles in the animal kingdom, with the potential to drive coevolutionary dynamics with their host population. Where hosts and parasites evolve together, we may find local adaptat... Read More about No evidence of local adaptation of immune responses to Gyrodactylus in three-spined stickleback (Gasterosteus aculeatus).

What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives (2016)
Journal Article
Collery, M. M., Kuehne, S. A., McBride, S. M., Kelly, M. L., Monot, M., Cockayne, A., Dupuy, B., & Minton, N. P. (2017). What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives. Virulence, 8(6), 767-781. https://doi.org/10.1080/21505594.2016.1237333

Clostridium difficile is a major cause of antibiotic induced diarrhoea worldwide, responsible for significant annual mortalities and represents a considerable economic burden on healthcare systems. The two main C. difficile virulence factors are toxi... Read More about What's a SNP between friends: The influence of single nucleotide polymorphisms on virulence and phenotypes of Clostridium difficile strain 630 and derivatives.

Seasonal and Spatial Variations of Saltmarsh Benthic Foraminiferal Communities from North Norfolk, England (2016)
Journal Article
Saad, S. A., & Wade, C. M. (2017). Seasonal and Spatial Variations of Saltmarsh Benthic Foraminiferal Communities from North Norfolk, England. Microbial Ecology, 73(3), 539-555. https://doi.org/10.1007/s00248-016-0895-5

© 2016, The Author(s). Time series foraminiferal data were obtained from samples collected from three sites at Brancaster Overy Staithe, Burnham Overy Staithe and Thornham on the North Norfolk coast over a 1-year period. At each collection point, six... Read More about Seasonal and Spatial Variations of Saltmarsh Benthic Foraminiferal Communities from North Norfolk, England.

Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity (2016)
Journal Article
Babraj, J., Cuthbertson, D. J., Leese, G., & Siervo, M. (2017). Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity. Clinical Nutrition, 36(6), 1716-1719. https://doi.org/10.1016/j.clnu.2016.11.012

© 2016 Background Ageing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss. We investigated whether anabolic resistance to feeding might underlie accelerated muscle loss in older people with T2DM and whether dysregulated m... Read More about Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.