Outputs (16)

Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development (2017)
Journal Article
Saini, E., Zeeshan, M., Brady, D., Pandey, R., Kaiser, G., Koreny, L., Kumar, P., Thakur, V., Tatiya, S., Katris, N. J., Limenitakis, R. S., Kaur, I., Green, J. L., Bottrill, A. R., Guttery, D. S., Waller, R. F., Heussler, V., Holder, A. A., Mohmmed, A., Malhotra, P., & Tewari, R. (in press). Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development. Scientific Reports, 7(1), Article 15577. https://doi.org/10.1038/s41598-017-15781-z

Plasmodium parasites, the causative agents of malaria, possess a distinctive membranous structure of flattened alveolar vesicles supported by a proteinaceous network, and referred to as the inner membrane complex (IMC). The IMC has a role in actomyos... Read More about Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development.

SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector (2016)
Journal Article
Wall, R. J., Roques, M., Katris, N. J., Koreny, L., Stanway, R. R., Brady, D., Waller, R. F., & Tewari, R. (2016). SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector. Scientific Reports, 6(1), https://doi.org/10.1038/srep28604

The SAS6-like (SAS6L) protein, a truncated paralogue of the ubiquitous basal body/centriole protein SAS6, has been characterised recently as a flagellum protein in trypanosomatids, but associated with the conoid in apicomplexan Toxoplasma. The conoid... Read More about SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector.

Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes (2015)
Journal Article
Roques, M., Wall, R. J., Douglass, A. P., Ramaprasad, A., Ferguson, D. J. P., Kaindama, M. L., Brusini, L., Joshi, N., Rchiad, Z., Brady, D., Guttery, D. S., Wheatley, S. P., Yamano, H., Holder, A. A., Pain, A., Wickstead, B., & Tewari, R. (2015). Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes. PLoS Pathogens, 11(11), Article e1005273. https://doi.org/10.1371/journal.ppat.1005273

Cell-cycle progression and cell division in eukaryotes are governed in part by the cyclin family and their regulation of cyclin-dependent kinases (CDKs). Cyclins are very well characterised in model systems such as yeast and human cells, but surprisi... Read More about Plasmodium P-type cyclin CYC3 modulates endomitotic growth during oocyst development in mosquitoes.

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain (2015)
Journal Article
Yusuf, N. A., Green, J. L., Wall, R. J., Knuepfer, E., Moon, R. W., Schulte-Huxel, C., Stanway, R. R., Martin‖, S. R., Howell, S. A., Douse, C. H., Cota, E., Tate, E. W., Tewari, R., & Holder, A. A. (2015). The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain. Journal of Chemical Sciences, 290, 12147-12164. https://doi.org/10.1074/jbc.M115.637694

Myosin B (MyoB) is one of the two short class XIV myosins encoded in the Plasmodium genome. Class XIV myosins are characterized by a catalytic “head,” a modified “neck,” and the absence of a “tail” region. Myosin A (MyoA), the other class XIV myosin... Read More about The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation (2014)
Journal Article
Guttery, D. S., TEWARI, R., Poulin, B., Ramaprasad, A., Wall, R. J., Ferguson, D. J., Brady, D., Patzewitz, E.-M., Whipple, S., Straschil, U., Wright, M. H., Mohamed, A. M., Radhakrishnan, A., Arold, S. T., Tate, E. W., Holder, A. A., Wickstead, B., & Pain, A. (2014). Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation. Cell Host and Microbe, 16(1), 128-140. https://doi.org/10.1016/j.chom.2014.05.020

Reversible protein phosphorylation regulated by kinases and phosphatases controls many cellular processes. Although essential functions for the malaria parasite kinome have been reported, the roles of most protein phosphatases (PPs) during Plasmodium... Read More about Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation.

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach (2013)
Journal Article
Wright, M., Clough, B., Rackham, M., Rangachari, K., Brannigan, J., Grainger, M., Moss, D., Bottrill, A., Heal, W., Broncel, M., Serwa, R., Brady, D., Mann, D., Leatherbarrow, R., Tewari, R., Wilkinson, A., Holder, A., & Tate, E. W. (2014). Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nature Chemistry, 6(2), 112-121. https://doi.org/10.1038/NCHEM.1830

Malaria is an infectious disease caused by parasites of the genus Plasmodium, which leads to approximately one million deaths per annum worldwide. Chemical validation of new antimalarial targets is urgently required in view of rising resistance to cu... Read More about Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.