Outputs (3)

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling (2017)
Journal Article
Halls, M., & Canals, M. (2018). Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling. Trends in Pharmacological Sciences, 39(2), 148-157. https://doi.org/10.1016/j.tips.2017.09.005

Genetically encoded Förster resonance energy transfer (FRET) biosensors have been instrumental to our understanding of how intracellular signalling is organised and regulated within cells. In the last decade, the toolbox, dynamic range and applicatio... Read More about Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling.

Ticks from diverse genera encode chemokine-inhibitory evasin proteins (2017)
Journal Article
Hayward, J., Sanchez, J., Perry, A., Huang, C., Rodriguez Valle, M., Canals, M., Payne, R. J., & Stone, M. J. (2017). Ticks from diverse genera encode chemokine-inhibitory evasin proteins. Journal of Biological Chemistry, 292(38), 15670-15680. https://doi.org/10.1074/jbc.M117.807255

To prolong residence on their hosts, ticks secrete many salivary factors that target host defense molecules. In particular, the tick Rhipicephalus sanguineus has been shown to produce three salivary glycoproteins named “evasins,” which bind to host c... Read More about Ticks from diverse genera encode chemokine-inhibitory evasin proteins.

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief (2017)
Journal Article
Porter, C. J., Lieu, T. M., Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Herenbrink, C. K., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., …Bunnett, N. W. (2017). Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief. Science Translational Medicine, 9(392), Article eaal3447. https://doi.org/10.1126/scitranslmed.aal3447

© 2017, American Association for the Advancement of Science. Typically considered to be cell surface sensors of extracellular signals, heterotrimeric GTP-binding protein (G protein)-coupled receptors (GPCRs) control many pathophysiological processes... Read More about Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.