Outputs (6)

Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS (2023)
Journal Article
Khateb, H., Hook, A. L., Kern, S., Watts, J. A., Singh, S., Jackson, D., Marinez-Pomares, L., Williams, P., & Alexander, M. R. (2023). Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS. Biointerphases, 18(3), Article 031007. https://doi.org/10.1116/6.0002604

Secondary ion mass spectrometry (SIMS) offers advantages over both liquid extraction mass spectrometry and matrix assisted laser desorption mass spectrometry in that it provides the direct in situ analysis of molecules and has the potential to preser... Read More about Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS.

Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function (2021)
Journal Article
Singh, S., Almuhanna, Y., Alshahrani, M. Y., Lowman, D. W., Rice, P. J., Gell, C., Ma, Z., Graves, B., Jackson, D., Lee, K., Juarez, R., Koranteng, J., Muntaka, S., Mitchell, D. A., da Silva, A. C., Hussain, F., Yilmaz, G., Mastrotto, F., Irie, Y., Williams, P., …Martinez-Pomares, L. (2021). Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function. npj Biofilms and Microbiomes, 7(1), Article 87. https://doi.org/10.1038/s41522-021-00257-w

Bacterial biofilms represent a challenge to the healthcare system because of their resilience against antimicrobials and immune attack. Biofilms consist of bacterial aggregates embedded in an extracellular polymeric substance (EPS) composed of polysa... Read More about Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function.

IFN-γ and IL-17A differentially influence the response of human macrophages and neutrophils to Pseudomonas aeruginosa infection (2018)
Journal Article
Muntaka, S., Almuhanna, Y., Jackson, D., Singh, S., Afryie-Asante, A., Cámara, M., & Martínez-Pomares, L. (2019). IFN-γ and IL-17A differentially influence the response of human macrophages and neutrophils to Pseudomonas aeruginosa infection. Infection and Immunity, 87(2), https://doi.org/10.1128/iai.00814-18

Macrophages are important orchestrators of inflammation during bacterial infection acting both as effector cells and as regulators of neutrophil recruitment and life span. Differently activated macrophage populations with distinct inflammatory and mi... Read More about IFN-γ and IL-17A differentially influence the response of human macrophages and neutrophils to Pseudomonas aeruginosa infection.

STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function (2014)
Journal Article
Ibrahem, S., Al‐Ghamdi, S., Baloch, K., Muhammad, B., Fadhil, W., Jackson, D., Nateri, A., & Ilyas, M. (2014). STAT3 paradoxically stimulates β‐catenin expression but inhibits β‐catenin function. International Journal of Experimental Pathology, 95(6), 392-400. https://doi.org/10.1111/iep.12102

Wnt signalling and the signal transducer and activator of transcription 3 (STAT3) are oncogenic signalling pathways which are deregulated in colorectal cancer (CRC). Here we investigated the interaction of these two pathways. Firstly, we investigated... Read More about STAT3 paradoxically stimulates ??catenin expression but inhibits ??catenin function.

Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas (2011)
Journal Article
Al-Ghamdi, S., Albasri, A., Cachat, J., Ibrahem, S., Muhammad, B. A., Jackson, D., Nateri, A. S., Kindle, K. B., & Ilyas, M. (2011). Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas. PLoS ONE, 6(6), Article e20919. https://doi.org/10.1371/journal.pone.0020919

CTEN/TNS4 is an oncogene in colorectal cancer (CRC) which enhances cell motility although the mechanism of Cten regulation is unknown. We found an association between high Cten expression and KRAS/BRAF mutation in a series of CRC cell lines (p = 0.03... Read More about Cten is targeted by Kras signalling to regulate cell motility in the colon and pancreas.

C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer (2008)
Journal Article
Albasri, A., Seth, R., Jackson, D., Benhasouna, A., Crook, S., Nateri, A. S., Chapman, R., & Ilyas, M. (2009). C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer. The Journal of Pathology, 218(1), 57-65. https://doi.org/10.1002/path.2508

The Tensin gene family encodes proteins thought to modulate integrin function. C-terminal Tensin-like (CTEN) is a member of the Tensin gene family which lacks the N-terminus actin-binding domain. Cten is reported to have both oncogenic and tumour-sup... Read More about C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer.