Outputs (31)

A systems biology viewpoint on autophagy in health and disease (2010)
Journal Article
Huett, A., Goel, G., & Xavier, R. J. (2010). A systems biology viewpoint on autophagy in health and disease. Current Opinion in Gastroenterology, 26(4), 302-309. https://doi.org/10.1097/MOG.0b013e32833ae2ed

Purpose of review: The field of autophagy is rapidly expanding to encompass many important areas of cell biology, physiology and disease. Recent discoveries and tools allow the connection of the autophagy pathway to other cellular signals and process... Read More about A systems biology viewpoint on autophagy in health and disease.

Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity (2010)
Journal Article
Ng, A. C., Eisenberg, J. M., Heath, R. J., Huett, A., Robinson, C. M., Nau, G. J., & Xavier, R. J. (2011). Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity. Proceedings of the National Academy of Sciences, 108(SUPPL. 1), 4631-4638. https://doi.org/10.1073/pnas.1000093107

In innate immune sensing, the detection of pathogen-associated molecular patterns by recognition receptors typically involve leucine-rich repeats (LRRs). We provide a categorization of 375 human LRR-containing proteins, almost half of which lack othe... Read More about Human leucine-rich repeat proteins: A genome-wide bioinformatic categorization and functional analysis in innate immunity.

Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly (2009)
Journal Article
Lapaquette, P., Glasser, A. L., Huett, A., Xavier, R. J., & Darfeuille-Michaud, A. (2009). Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cellular Microbiology, 12(1), 99-113. https://doi.org/10.1111/j.1462-5822.2009.01381.x

Ileal lesions in Crohn's disease (CD) patients are colonized by pathogenic adherent-invasive Escherichia coli (AIEC) able to invade and to replicate within intestinal epithelial cells. Recent genome-wide association studies have highlighted the autop... Read More about Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly.

Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases (2009)
Journal Article
Huett, A., & Xavier, R. J. (2010). Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases. Inflammatory Bowel Diseases, 16(1), 152-174. https://doi.org/10.1002/ibd.20991

Autophagy is a conserved homeostatic process by which cells degrade and recycle cytoplasmic contents and organelles. Recently, autophagy has come to prominence as a factor in many disease states, including inflammatory bowel diseases. In this review... Read More about Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases.

The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements (2009)
Journal Article
Huett, A., Leong, J. M., Podolsky, D. K., & Xavier, R. J. (2009). The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements. Experimental Cell Research, 315(12), 2001-2011. https://doi.org/10.1016/j.yexcr.2009.04.003

The common gastrointestinal pathogens enteropathogenic Escherichia coli (EPEC) and Salmonella typhimurium both reorganize the gut epithelial cell actin cytoskeleton to mediate pathogenesis, utilizing mimicry of the host signaling apparatus. The PDZ d... Read More about The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy (2009)
Journal Article
Huett, A., Ng, A., Cao, Z., Kuballa, P., Komatsu, M., Daly, M. J., Podolsky, D. K., & Xavier, R. J. (2009). A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. Journal of Immunology, 182(8), 4917-4930. https://doi.org/10.4049/jimmunol.0803050

Autophagy is a conserved cellular process required for the removal of defective organelles, protein aggregates, and intracellular pathogens. We used a network analysis strategy to identify novel human autophagy components based upon the yeast interac... Read More about A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant (2008)
Journal Article
Kuballa, P., Huett, A., Rioux, J. D., Daly, M. J., & Xavier, R. J. (2008). Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE, 3(10), Article e3391. https://doi.org/10.1371/journal.pone.0003391

The genetic risk factors predisposing individuals to the development of inflammatory bowel disease are beginning to be deciphered by genome-wide association studies. Surprisingly, these new data point towards a critical role of autophagy in the patho... Read More about Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease (2008)
Journal Article
McCarroll, S. A., Huett, A., Kuballa, P., Chilewski, S. D., Landry, A., Goyette, P., Zody, M. C., Hall, J. L., Brant, S. R., Cho, J. H., Duerr, R. H., Silverberg, M. S., Taylor, K. D., Rioux, J. D., Altshuler, D., Daly, M. J., & Xavier, R. J. (2008). Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nature Genetics, 40(9), 1107-1112. https://doi.org/10.1038/ng.215

Following recent success in genome-wide association studies, a critical focus of human genetics is to understand how genetic variation at implicated loci influences cellular and disease processes. Crohn's disease (CD) is associated with SNPs around I... Read More about Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.

Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers (2008)
Journal Article
Huett, A., & Xavier, R. J. (2008). Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers. Gastroenterology, 134(7), 2164-2168. https://doi.org/10.1053/j.gastro.2008.04.013

Robert Koch was the first to propose a series of definitive tests to determine the agents of infectious disease. Koch's postulates, first published in 1890, were subsequently updated for the molecular era in 1988 by Stanley Falkow1 and continue to fo... Read More about Neither Hide Nor Hair: The Difficulty of Identifying Useful Disease Biomarkers.

Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis (2008)
Journal Article
Xavier, R. J., Huett, A., & Rioux, J. D. (2008). Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis. Gut, 57(6), 717-720. https://doi.org/10.1136/gut.2007.134254

Crohns disease (CD) is a complex polygenic trait whereby multiple genetic and non-genetic risk factors contribute to disease susceptibility. Association testing is a statistical approach commonly used for identifying genetic risk factors for complex/... Read More about Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis.