Outputs (153)

Quorum sensing signals of the grapevine crown gall bacterium, Novosphingobium sp. Rr2-17: use of inducible expression and polymeric resin to sequester acyl-homoserine lactones (2024)
Journal Article
Gan, H. M., Dailey, L., Wengert, P., Halliday, N., Williams, P., Hudson, A., & Savka, M. A. (2024). Quorum sensing signals of the grapevine crown gall bacterium, Novosphingobium sp. Rr2-17: use of inducible expression and polymeric resin to sequester acyl-homoserine lactones. PeerJ, 12, Article e18657. https://doi.org/10.7717/peerj.18657

Background: A grapevine crown gall tumor strain, Novosphingobium sp. strain Rr2- 17 was previously reported to accumulate copious amounts of diverse quorum sensing signals during growth. Genome sequencing identified a single luxI homolog in strain Rr... Read More about Quorum sensing signals of the grapevine crown gall bacterium, Novosphingobium sp. Rr2-17: use of inducible expression and polymeric resin to sequester acyl-homoserine lactones.

Identification of a novel nuclease activity in human DDX49 helicase (2024)
Journal Article
Parkes, A. J., Anandavijayan, S., Lou-Hing, A., Downs, O., Killelea, T., Martin, L., Kapllanaj, F., & Bolt, E. L. (2024). Identification of a novel nuclease activity in human DDX49 helicase. Royal Society Open Science, 11(12), Article 241891. https://doi.org/10.1098/rsos.241891

Human DDX49 is an emerging target in cancer progression and retroviral diseases through its essential roles in nucleolar RNA processing. Here, we identify nuclease activity of human DDX49, which requires active site aspartate residues within a conser... Read More about Identification of a novel nuclease activity in human DDX49 helicase.

Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment (2024)
Journal Article
Milborne, B., Arjuna, A., Islam, T., Arafat, A., Layfield, R., Thompson, A., & Ahmed, I. (2024). Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment. ACS Omega, 9(52), 50933-50944. https://doi.org/10.1021/acsomega.4c02825

This study presents the development and characterisation of high yttrium-content phosphate-based glass-ceramic microspheres for potential applications in bone cancer radiotherapy treatment. The microspheres produced via flame spheroidisa-tion, follow... Read More about Yttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment.

Creatine supplementation strategies aimed at acutely increasing and maintaining skeletal muscle total creatine content in healthy, young volunteers (2024)
Journal Article
Pittas, G., Miller, J., Laithwaite, D., & Greenhaff, P. (2024). Creatine supplementation strategies aimed at acutely increasing and maintaining skeletal muscle total creatine content in healthy, young volunteers. Translational Exercise Biomedicine, https://doi.org/10.1515/teb-2024-0032

Objectives: Insight regarding dietary creatine (Cr) supple-mentation strategies to acutely increase and maintain muscle total creatine (TCr) content is missing. Methods: Healthy, young, men ingested 4 × 5 g Cr/day (d) for 5d, followed by 5 g/d for 28... Read More about Creatine supplementation strategies aimed at acutely increasing and maintaining skeletal muscle total creatine content in healthy, young volunteers.

Myosin VI drives arrestin-independent internalization and signaling of GPCRs (2024)
Journal Article
Patel, N. M., Ripoll, L., Peach, C. J., Ma, N., Blythe, E. E., Vaidehi, N., Bunnett, N. W., von Zastrow, M., & Sivaramakrishnan, S. (2024). Myosin VI drives arrestin-independent internalization and signaling of GPCRs. Nature Communications, 15, Article 10636. https://doi.org/10.1038/s41467-024-55053-9

G protein-coupled receptor (GPCR) endocytosis is canonically associated with β-arrestins. Here, we delineate a β-arrestin-independent endocytic pathway driven by the cytoskeletal motor, myosin VI. Myosin VI engages GIPC, an adaptor protein that binds... Read More about Myosin VI drives arrestin-independent internalization and signaling of GPCRs.

Distribution of the schistosome intermediate snail host Biomphalaria pfeifferi in East Africa's river systems and the prevalence of Schistosoma mansoni infection (2024)
Journal Article
Magero, V. O., Kisara, S., Suleman, M. A., & Wade, C. M. (2025). Distribution of the schistosome intermediate snail host Biomphalaria pfeifferi in East Africa's river systems and the prevalence of Schistosoma mansoni infection. Transactions of The Royal Society of Tropical Medicine and Hygiene, 119(3), 253-265. https://doi.org/10.1093/trstmh/trae115

Background:

There is a need for current and more detailed information on the distribution of Biomphalaria pfeifferi snails in East Africa’s river systems. B. pfeifferi is arguably the most important snail intermediate host in the transmission of... Read More about Distribution of the schistosome intermediate snail host Biomphalaria pfeifferi in East Africa's river systems and the prevalence of Schistosoma mansoni infection.

Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation (2024)
Journal Article
Bowley, G., Irving, S., Hoefer, I., Wilkinson, R., Pasterkamp, G., Darwish, H. M. S., White, S., Francis, S. E., Chico, T., Noel, E., Serbanovic-Canic, J., & Evans, P. C. (2024). Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports, 14, Article 30130. https://doi.org/10.1038/s41598-024-77370-1

Local haemodynamics control arterial homeostasis and dysfunction by generating wall shear stress (WSS) which regulates endothelial cell (EC) physiology. Here we use a zebrafish model to identify genes that regulate EC proliferation in response to flo... Read More about Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation.

The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain (2024)
Journal Article
McWilliams, D. F., Shahtaheri, M., Koushesh, S., Joseph, C., Gowler, P. R., Xu, L., Chapman, V., Sofat, N., & Walsh, D. A. (2025). The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain. Osteoarthritis and Cartilage Open, 7(1), Article 100544. https://doi.org/10.1016/j.ocarto.2024.100544

Objectives
Histological osteochondral characteristics of inflammation, fibrosis, vascularity, cartilage islands, vessels entering cartilage, thickened trabeculae and cysts are associated with bone marrow lesions (BMLs) in human knee osteoarthritis (... Read More about The rat osteoarthritis bone score for histological pathology relevant to human bone marrow lesions and pain.

Meningitis (bacterial) and meningococcal disease: recognition, diagnosis and management-summary of updated NICE guidance (2024)
Journal Article
Paing, A., Elliff-O'Shea, L., Boardman, L., Turner, D., Glennie, L., Arora, A., Bryan, M., Faust, S., Griffiths, N., Heyderman, R., Hitchings, A., Jawaid, I., Maconochie, I., Nadel, S., Thomas, M., Trivedi, A., Bhattacharrya, D., Griffiths, M., Heath, P., Tubman, R., …Iheozor-Ejiofor, Z. (2024). Meningitis (bacterial) and meningococcal disease: recognition, diagnosis and management-summary of updated NICE guidance. BMJ, 387, Article q2452. https://doi.org/10.1136/bmj.q2452

Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models (2024)
Journal Article
Peach, C. J., Tonello, R., Damo, E., Gomez, K., Calderon-Rivera, A., Bruni, R., Bansia, H., Maile, L., Manu, A. M., Hahn, H., Thomsen, A. R., Schmidt, B. L., Davidson, S., des Georges, A., Khanna, R., & Bunnett, N. W. (2025). Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models. Journal of Clinical Investigation, 135(4), Article e183873. https://doi.org/10.1172/JCI183873

Nerve growth factor (NGF) monoclonal antibodies inhibit chronic pain, yet failed to gain approval due to worsened joint damage in osteoarthritis patients. We report that neuropilin-1 (NRP1) is a coreceptor for NGF and tropomyosin-related kinase A (Tr... Read More about Neuropilin-1 inhibition suppresses nerve growth factor signaling and nociception in pain models.